Understanding amyloidosis: symptoms and diagnosis

Understanding amyloidosis: symptoms and diagnosis

Understanding amyloidosis: symptoms, diagnosis and outlook

Amyloidosis is a rare disease affecting a limited number of people worldwide. Although little known, it can have a significant impact on patients’ quality of life. In this article, we will explore in detail the signs and symptoms of amyloidosis, the diagnostic methods available and current treatment prospects.

What is amyloidosis?

Amyloidosis is a disease characterized by the abnormal accumulation of proteins called amyloids in body tissues. These amyloid deposits usually form in organs such as the heart, kidneys, liver, intestines, nerves and skin. Over time, these deposits can interfere with the normal function of the affected organ, leading to a variety of symptoms.

Signs and symptoms of amyloidosis

Symptoms of amyloidosis vary according to the organ affected. However, some common signs may include:

  1. Fatigue and general weakness: Amyloidosis patients may experience chronic fatigue and decreased energy levels.
  2. Kidney problems: Renal amyloidosis can cause kidney failure, manifested by increased urination, back pain, swollen limbs and increased fatigue.
  3. Heart problems: Cardiac amyloidosis can lead to heart failure, arrhythmia, chest pain, excessive fatigue and shortness of breath during physical exertion.
  4. Gastrointestinal problems: Some patients may experience digestive problems such as nausea, vomiting, abdominal pain or diarrhea.
  5. Numbness and tingling: Peripheral nerve amyloidosis may cause abnormal sensations in the limbs, such as tingling, numbness and decreased tactile sensitivity.


Amyloidosis is a complex disease that can affect different organs of the body. Early recognition of symptoms and accurate diagnosis are essential for disease management.
Although current treatment options do not offer a complete cure for amyloidosis, they do offer the potential to relieve symptoms and improve patients’ quality of life.
Ongoing research in this field is crucial to developing new therapeutic strategies and improving treatment prospects in the future.