Research
Clinical trials
Every amyloidosis study now recruiting, about to open, or enrolling by invitation, anywhere in the world, listed straight from ClinicalTrials.gov and refreshed every day.
Information, not medical advice. The Alliance does not run these studies and cannot enrol you in one. If a trial looks relevant, discuss it with the doctor who follows your amyloidosis.
Recruiting and upcoming studies
The list covers AL, ATTR and AA amyloidosis as well as cerebral amyloid angiopathy. Each card says where the study stands: open to anyone who meets its criteria, not yet open, or restricted to people the investigators invite. Studies that close simply leave the list.
Showing 145–156 of 208 trials
RecruitingATTR (transthyretin)
Real-Life Clinical Efficacy of Acoramidis in Participants With ATTR-CM and Association With Cardiac Biomarkers (opens on ClinicalTrials.gov)
The purpose of this study is to confirm that the treatment with acoramidis prevents the deterioration of the ATTR-CM disease progression index and that…
- Study
- Interventional (treatment)
- Phase
- Phase 4
- Sponsor
- Alexion Pharmaceuticals, Inc.
Recruiting in: Japan
NCT07306949Updated 7 January 2026
RecruitingATTR (transthyretin)
ATTR Amyloid Cardiomyopathy: Characterization of Extracellular Vesicles as Potential Disease Stratifiers and Prognostic Biomarkers (opens on ClinicalTrials.gov)
This study explores whether extracellular vesicles (EVs) tiny particles released into the bloodstream by cells can serve as early and minimally invasive biomarkers for…
- Study
- Observational (registry, imaging)
- Sponsor
- University of Sao Paulo General Hospital
Recruiting in: Brazil
NCT07314268Updated 2 January 2026
RecruitingNot specified
Minimal Residual Disease Response-adapted Deferral of Transplant in Dysproteinemia (MILESTONE) (opens on ClinicalTrials.gov)
This is a phase II interventional study evaluating the use of minimal residual disease by next generation sequencing to defer autologous hematopoietic stem cell…
- Study
- Interventional (treatment)
- Phase
- Phase 2
- Sponsor
- University of Alabama at Birmingham
Recruiting in: United States
NCT04991103Updated 31 December 2025
RecruitingNot specified
A Study Of Myocardial Stiffness In Amyloidosis With Magnetic Resonance Elastography (opens on ClinicalTrials.gov)
This is a prospective case control study to determine the feasibility and utility of myocardial stiffness assessment by cardiac magnetic resonance elastography (MRE) in…
- Study
- Observational (registry, imaging)
- Sponsor
- Mayo Clinic
Recruiting in: United States
NCT07216469Updated 26 December 2025
RecruitingNot specified
Generative AI Impact on Rheumatoid Arthritis Complications Diagnosis (opens on ClinicalTrials.gov)
Generative AI (GenAI) based on large language models (LLMs) is expected to improve the diagnosis and treatment of autoimmune diseases. We are studying how…
- Study
- Observational (registry, imaging)
- Sponsor
- Guang'anmen Hospital of China Academy of Chinese Medical Sciences
Recruiting in: China
NCT07301892Updated 24 December 2025
RecruitingNot specified
A Study Of MCG In Cardiac Amyloidosis (opens on ClinicalTrials.gov)
The primary objective of this observational study is to evaluate the utility of magnetocardiography (MCG) in diagnosing and monitoring disease progression in patients with…
- Study
- Observational (registry, imaging)
- Sponsor
- Mayo Clinic
Recruiting in: United States
NCT07218705Updated 22 December 2025
RecruitingATTR (transthyretin)
Multimodality Cardiac Imaging for Disease Progression in ATTR-CM (opens on ClinicalTrials.gov)
The goal of this clinical trial is to investigate whether new imaging techniques can help us to better understand the cardiac amyloidosis. The disease…
- Study
- Interventional (treatment)
- Sponsor
- Dominik Benz
Recruiting in: Switzerland
NCT07112066Updated 9 December 2025
RecruitingNot specified
Cancer and Aging Resilience Evaluation in Older Adults With Hematologic Malignancies: The CARE-Heme Registry (opens on ClinicalTrials.gov)
The primary purpose of this protocol is to create a registry of older (≥50 years old) patients with Hematologic Malignancies. Our main objectives include:…
- Study
- Observational (registry, imaging)
- Sponsor
- University of Alabama at Birmingham
Recruiting in: United States
NCT05556928Updated 8 December 2025
RecruitingNot specified
Prevalence of Amyloidosis in Trauma Patients (opens on ClinicalTrials.gov)
This study aims to determine the frequency of amyloidosis among patients undergoing trauma surgery.
- Study
- Observational (registry, imaging)
- Sponsor
- Consorci Sanitari de l'Alt Penedès i Garraf
Recruiting in: Spain
NCT06527521Updated 2 December 2025
RecruitingAL (light chain)
Study Evaluating the Efficacy and Safety of CM336 Injection in the Treatment of Light-Chain Amyloidosis (opens on ClinicalTrials.gov)
to Evaluate the Efficacy and Safety of CM336 (BCMA/CD3 Bispecific Antibody) in Adults with Relapsed or Refractory Primary Light-Chain Amyloidosis
- Study
- Interventional (treatment)
- Phase
- Phase 2
- Sponsor
- Keymed Biosciences Co.Ltd
Recruiting in: China
NCT07039578Updated 26 November 2025
RecruitingNot specified
Registry for Adults With Plasma Cell Disorders (PCD’s) (opens on ClinicalTrials.gov)
The primary purpose of this protocol is to create a registry of patients with plasma cell disorders (PCDs), including for example the cancer multiple…
- Study
- Observational (registry, imaging)
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Recruiting in: United States
NCT03717844Updated 20 November 2025
RecruitingNot specified
Molecular Imaging of Primary Amyloid Cardiomyopathy (opens on ClinicalTrials.gov)
Cardiac amyloidosis is a major cause of early treatment-related death and poor overall survival in individuals with systemic light chain amyloidosis. This project will…
- Study
- Interventional (treatment)
- Sponsor
- Brigham and Women's Hospital
Recruiting in: United States
NCT02641145Updated 14 November 2025
This list only covers amyloidosis studies that are open or about to open. The registry holds every study, including those already completed.
Source: ClinicalTrials.gov (U.S. National Library of Medicine). List last retrieved on 25 September 2026. clinicaltrials.gov
Not sure where to start?
Our member associations know the teams running these studies in their own country, and can help you prepare the conversation with your doctor.