Research
Clinical trials
Every amyloidosis study now recruiting, about to open, or enrolling by invitation, anywhere in the world, listed straight from ClinicalTrials.gov and refreshed every day.
Information, not medical advice. The Alliance does not run these studies and cannot enrol you in one. If a trial looks relevant, discuss it with the doctor who follows your amyloidosis.
Recruiting and upcoming studies
The list covers AL, ATTR and AA amyloidosis as well as cerebral amyloid angiopathy. Each card says where the study stands: open to anyone who meets its criteria, not yet open, or restricted to people the investigators invite. Studies that close simply leave the list.
Showing 133–144 of 208 trials
Enrolling by invitationATTR (transthyretin)
A Study to Evaluate Vutrisiran in Patients With Transthyretin Amyloidosis With Cardiomyopathy (opens on ClinicalTrials.gov)
The purpose of this study is to obtain safety, efficacy, and pharmacodynamic data on the use of vutrisiran in patients with ATTR amyloidosis with…
- Study
- Interventional (treatment)
- Phase
- Phase 3
- Sponsor
- Alnylam Pharmaceuticals
Recruiting in: ArgentinaAustriaBelgiumBrazil+13
NCT06679946Updated 20 February 2026
Not yet recruitingATTR (transthyretin)
Increased Pacemaker Lower Rate in ATTR Cardiac Amyloidosis (opens on ClinicalTrials.gov)
In cardiac amyloidosis, the heart muscle becomes thick and stiff, making it difficult to pump enough blood with each beat. The heart also often…
- Study
- Interventional (treatment)
- Sponsor
- Region Skane
Recruiting in: DenmarkSweden
NCT07413081Updated 17 February 2026
RecruitingCerebral amyloid angiopathy
A Study of AMDX-2011P in Participants With CAA (opens on ClinicalTrials.gov)
The purpose of this study is to assess safety, tolerability, plasma pharmacokinetics and biologic activity of a single intravenous dose of AMDX-2011P in participants…
- Study
- Interventional (treatment)
- Phase
- Phase 2
- Sponsor
- Amydis Inc.
Recruiting in: United States
NCT05709314Updated 13 February 2026
RecruitingAL (light chain)
A Study to Evaluate the Safety and Efficacy of SCTC21C in Combination With Bortezomib, Cyclophosphamide, and Dexamethasone in Patients With Newly Diagnosed Systemic Light-Chain Amyloidosis (NDSLCA) (opens on ClinicalTrials.gov)
The purpose of this study is to evaluate the efficacy and safety of SCTC21C plus cyclophosphamide, bortezomib and dexamethasone (VCd) compared with VCd alone…
- Study
- Interventional (treatment)
- Phase
- Phase 3
- Sponsor
- Sinocelltech Ltd.
Recruiting in: China
NCT07388602Updated 5 February 2026
RecruitingNot specified
Myocardial Perfusion CMR for Differentiating and Characterizing Hypertrophic Cardiomyopathy Phenotypes (opens on ClinicalTrials.gov)
This observational study aims to evaluate myocardial perfusion abnormalities using quantitative and qualitative cardiac magnetic resonance (CMR) perfusion imaging in patients with hypertrophic cardiomyopathy…
- Study
- Observational (registry, imaging)
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Recruiting in: Italy
NCT07382128Updated 2 February 2026
Not yet recruitingNot specified
Microneedling Alone vs Microneedling With PRP in the Treatment of Macular Amyloidosis; a Split Face Comparative Study (opens on ClinicalTrials.gov)
This study is going to asses and compare the efficacy of treatment of macular amyloidosis using microneedling vs PRP with microneedling. Pruritus and pigmentation…
- Study
- Interventional (treatment)
- Sponsor
- Cairo University
No study locations listed yet
NCT07360860Updated 22 January 2026
RecruitingNot specified
Multimodal Analysis of Endomyocardial Biopsies (opens on ClinicalTrials.gov)
The goal of this observational study is to pursue a multimodal approach to identify the molecular signatures and immune signalling molecules of various myocardial…
- Study
- Observational (registry, imaging)
- Sponsor
- University Hospital, Essen
Recruiting in: Germany
NCT07359690Updated 22 January 2026
RecruitingNot specified
Precision Diagnosis and Risk Stratification of Rare Cardiomyopathies Based on Novel Cardiac Magnetic Resonance Techniques (opens on ClinicalTrials.gov)
What is this study about? This research is focused on improving the care for people with rare heart muscle diseases, known as rare cardiomyopathies.…
- Study
- Observational (registry, imaging)
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Recruiting in: China
NCT07336394Updated 21 January 2026
Not yet recruitingATTR (transthyretin)
Cardiac Amyloidosis in Patients With Aortic Stenosis (opens on ClinicalTrials.gov)
This study intends to conduct a prospective observation to investigate the prevalence of cardiac amyloidosis (CA) in patients with aortic stenosis (AS), compare the…
- Study
- Observational (registry, imaging)
- Sponsor
- Shanghai Zhongshan Hospital
No study locations listed yet
NCT07170306Updated 20 January 2026
RecruitingNot specified
Amylo-Shiatsu-Acute-Chronic: Effects of Shiatsu on Symptoms and Quality of Life of Amyloidosis Patients (opens on ClinicalTrials.gov)
The objective of this study is to assess the beneficial effects of three targeted Shiatsu sessions compared to "comfort" Shiatsu on symptoms in patients…
- Study
- Interventional (treatment)
- Sponsor
- Assistance Publique – Hôpitaux de Paris
Recruiting in: France
NCT06197165Updated 15 January 2026
RecruitingNot specified
Institutional Registry of Rare Diseases (opens on ClinicalTrials.gov)
The goal of this observational study is to create a single macro registry system with data collection on common clinical features, grouping the different…
- Study
- Observational (registry, imaging)
- Sponsor
- Hospital Italiano de Buenos Aires
Recruiting in: Argentina
NCT06573723Updated 14 January 2026
RecruitingATTR (transthyretin)
Determining the Association of TTR Stabilizing Therapy With Circulating TTR Amyloid Aggregates Over Time in Patients With ATTR-CM: Longitudinal Biomarker Study (opens on ClinicalTrials.gov)
The objective of this study is to determine the association of clinically prescribed, on-label, TTR stabilizing therapy (e.g. tafamidis or acoramidis) with levels of…
- Study
- Observational (registry, imaging)
- Sponsor
- University of Texas Southwestern Medical Center
Recruiting in: United States
NCT07196839Updated 7 January 2026
This list only covers amyloidosis studies that are open or about to open. The registry holds every study, including those already completed.
Source: ClinicalTrials.gov (U.S. National Library of Medicine). List last retrieved on 25 September 2026. clinicaltrials.gov
Not sure where to start?
Our member associations know the teams running these studies in their own country, and can help you prepare the conversation with your doctor.