Research
Clinical trials
Every amyloidosis study now recruiting, about to open, or enrolling by invitation, anywhere in the world, listed straight from ClinicalTrials.gov and refreshed every day.
Information, not medical advice. The Alliance does not run these studies and cannot enrol you in one. If a trial looks relevant, discuss it with the doctor who follows your amyloidosis.
Recruiting and upcoming studies
The list covers AL, ATTR and AA amyloidosis as well as cerebral amyloid angiopathy. Each card says where the study stands: open to anyone who meets its criteria, not yet open, or restricted to people the investigators invite. Studies that close simply leave the list.
Showing 121–132 of 208 trials
Not yet recruitingNot specified
CAR-NK Therapy for Cardiac Amyloidosis (opens on ClinicalTrials.gov)
Relapsed/refractory (R/R) light chain cardiac amyloidosis is associated with a poor prognosis, and cellular immunotherapy constitutes a crucial therapeutic modality for these patients. The…
- Study
- Interventional (treatment)
- Phase
- Phase 1
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
No study locations listed yet
NCT07504289Updated 31 March 2026
RecruitingAL (light chain)
Daratumumab Maintenance Therapy for Improving Survival in Patients With Light Chain Amyloidosis, EMILIA Trial (opens on ClinicalTrials.gov)
This phase II trial compares shorter-duration versus longer-duration maintenance therapy with daratumumab for improving survival in patients who have received initial treatment with daratumumab…
- Study
- Interventional (treatment)
- Phase
- Phase 2
- Sponsor
- Mayo Clinic
Recruiting in: United States
NCT05898646Updated 30 March 2026
RecruitingCerebral amyloid angiopathy
SEarchiNg biomarkErs Cerebral Amyloid Angiopathy (SENECA) (opens on ClinicalTrials.gov)
Cerebral amyloid angiopathy (CAA) is one of the major types of cerebral small vessel disease, and a leading cause of spontaneous intracerebral hemorrhage and…
- Study
- Observational (registry, imaging)
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Recruiting in: Italy
NCT04204642Updated 30 March 2026
RecruitingATTR (transthyretin)
MAGNITUDE: A Phase 3 Study of NTLA-2001 in Participants With Transthyretin Amyloidosis With Cardiomyopathy (ATTR-CM) (opens on ClinicalTrials.gov)
To evaluate the efficacy and safety of a single dose of NTLA-2001 compared to placebo in participants with ATTR-CM.
- Study
- Interventional (treatment)
- Phase
- Phase 3
- Sponsor
- Intellia Therapeutics
Recruiting in: ArgentinaAustraliaAustriaBelgium+22
NCT06128629Updated 27 March 2026
RecruitingATTR (transthyretin)
The Italian Transthyretin Amyloidosis Web-Network (opens on ClinicalTrials.gov)
The study aims, by generating a large registry of patients with ATTR amyloidosis, including data at diagnosis and during follow up, to describe the…
- Study
- Observational (registry, imaging)
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Recruiting in: Italy
NCT05444920Updated 27 March 2026
RecruitingATTR (transthyretin)
Comprehensive Program for Hereditary Transthyretin Amyloidosis (opens on ClinicalTrials.gov)
The Comprehensive Program for Hereditary Transthyretin Amyloidosis describes a prospective observational study focused on understanding hereditary transthyretin amyloidosis (ATTR), a progressive and potentially fatal…
- Study
- Observational (registry, imaging)
- Sponsor
- Hospital de Alta Complejidad en Red
Recruiting in: Argentina
NCT07213297Updated 24 March 2026
RecruitingAL (light chain)
Ohio State University Multiple Myeloma and Amyloidosis Data Registry and Sample Resource (opens on ClinicalTrials.gov)
The investigators are researching patients with diseases of their plasma cells in order to improve their quality and length of life. The investigators have…
- Study
- Observational (registry, imaging)
- Sponsor
- Ohio State University Comprehensive Cancer Center
Recruiting in: United States
NCT01408225Updated 23 March 2026
RecruitingAL (light chain)
Rapid dFLC Response Predict CHR in AL Amyloidosis (opens on ClinicalTrials.gov)
Light chain amyloidosis (AL amyloidosis) is a rare plasma cell dyscrasia characterized by the deposition of insoluble amyloid fibrils in multiple organ systems. The…
- Study
- Observational (registry, imaging)
- Sponsor
- Peking University People's Hospital
Recruiting in: China
NCT06627309Updated 9 March 2026
RecruitingAL (light chain)
Investigating the Pathogenic Role of N-glycosylation in AL Amyloidosis: Molecular Bases, Diagnosis, and Treatment (opens on ClinicalTrials.gov)
Immunoglobulin light chain (AL) amyloidosis is caused by a typically small, minimally proliferating bone marrow plasma cell clone secreting a patient-unique, unstable, aggregation-prone, toxic…
- Study
- Observational (registry, imaging)
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Recruiting in: Italy
NCT07448779Updated 4 March 2026
RecruitingNot specified
CHEST-CA: Study of Chest Pain and Hidden Cardiac Amyloidosis (opens on ClinicalTrials.gov)
The objective of this observational, prospective study is to determine the prevalence of Cardiac Amyloidosis (CA) in males over the age of 65 who…
- Study
- Interventional (treatment)
- Sponsor
- Rigshospitalet, Denmark
Recruiting in: Denmark
NCT07435168Updated 27 February 2026
Enrolling by invitationATTR (transthyretin)
ATTRACT-52: Primary Care Cardiac Amyloidosis Screening in Ordu, Turkey (opens on ClinicalTrials.gov)
Cardiac amyloidosis is a progressive infiltrative cardiomyopathy, most commonly related to transthyretin (ATTR) misfolding. Although considered rare, emerging data suggest higher prevalence in specific…
- Study
- Observational (registry, imaging)
- Sponsor
- Kotyora Family Medicine Health Management and Education Association
Recruiting in: Turkey (Türkiye)
NCT07238426Updated 25 February 2026
Enrolling by invitationCerebral amyloid angiopathy
Stimulating Amyloid Clearance in Cerebral Amyloid Angiopathy (opens on ClinicalTrials.gov)
A pre-post study will be conducted to assess whether treatment with LXB, nVNS or a combination of both interventions can enhance the clearance of…
- Study
- Interventional (treatment)
- Phase
- Phase 2
- Sponsor
- Leiden University Medical Center
Recruiting in: Netherlands
NCT06421532Updated 24 February 2026
This list only covers amyloidosis studies that are open or about to open. The registry holds every study, including those already completed.
Source: ClinicalTrials.gov (U.S. National Library of Medicine). List last retrieved on 25 September 2026. clinicaltrials.gov
Not sure where to start?
Our member associations know the teams running these studies in their own country, and can help you prepare the conversation with your doctor.