Research
Clinical trials
Every amyloidosis study now recruiting, about to open, or enrolling by invitation, anywhere in the world, listed straight from ClinicalTrials.gov and refreshed every day.
Information, not medical advice. The Alliance does not run these studies and cannot enrol you in one. If a trial looks relevant, discuss it with the doctor who follows your amyloidosis.
Recruiting and upcoming studies
The list covers AL, ATTR and AA amyloidosis as well as cerebral amyloid angiopathy. Each card says where the study stands: open to anyone who meets its criteria, not yet open, or restricted to people the investigators invite. Studies that close simply leave the list.
Showing 109–120 of 208 trials
Not yet recruitingNot specified
Early Detection of Concealed Cardiac Amyloidosis Using AI-ECG and CT-Derived Extracellular Volume in Patients With Atrial Fibrillation (opens on ClinicalTrials.gov)
This study investigates the clinical efficacy of a non-invasive screening protocol using AI-ECG and CT-ECV analysis for cardiac amyloidosis. The study targets on atrial…
- Study
- Interventional (treatment)
- Sponsor
- Samsung Medical Center
Recruiting in: South Korea
NCT07567508Updated 5 May 2026
RecruitingNot specified
Cardiac Amyloidosis pRevaleNce of in OLDer Subjects Affected by Heart Failure (opens on ClinicalTrials.gov)
Tne aim purpose of this observational, multicentre and propective study is to determine the prevalence of cardiac amyloidosis in geriatric patients aged 80 years…
- Study
- Observational (registry, imaging)
- Sponsor
- Gérond'if
Recruiting in: France
NCT06427304Updated 20 April 2026
Enrolling by invitationATTR (transthyretin)
An Extension Study to Assess Long-Term Safety of Eplontersen in Adults With Transthyretin-Mediated Amyloid Cardiomyopathy (ATTR-CM) (opens on ClinicalTrials.gov)
The purpose of this study is to evaluate the safety and tolerability of extended dosing with eplontersen in participants with ATTR-CM.
- Study
- Interventional (treatment)
- Phase
- Phase 3
- Sponsor
- Ionis Pharmaceuticals, Inc.
Recruiting in: ArgentinaAustraliaAustriaBelgium+16
NCT05667493Updated 17 April 2026
RecruitingAL (light chain)
A EUropean REgistry and Sample Sharing networK to Promote the Diagnosis and Management of Light Chain Amyloidosis (EUREKA) (opens on ClinicalTrials.gov)
A prospective patients' registry collecting all new cases of AL amyloidosis evaluated at referral Centers from across Europe and a sample sharing network will…
- Study
- Observational (registry, imaging)
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Recruiting in: GermanyItalyNetherlandsSpain+2
NCT06205953Updated 16 April 2026
RecruitingATTR (transthyretin)
A Phase 3 Study of NTLA-2001 in ATTRv-PN (opens on ClinicalTrials.gov)
This study will be conducted to evaluate the efficacy and safety of a single dose of nexiguran ziclumeran (NTLA-2001) compared to placebo in participants…
- Study
- Interventional (treatment)
- Phase
- Phase 3
- Sponsor
- Intellia Therapeutics
Recruiting in: ArgentinaBrazilMexicoSingapore+2
NCT06672237Updated 16 April 2026
RecruitingAL (light chain)
A Registry of AL Amyloidosis (ReAL) (opens on ClinicalTrials.gov)
The purpose of this protocol is to generate a large registry of patients with AL amyloidosis.
- Study
- Observational (registry, imaging)
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Recruiting in: Italy
NCT04839003Updated 16 April 2026
RecruitingNot specified
A Study Of Deep Learning For Echo Analysis, Tracking, And Evaluation (opens on ClinicalTrials.gov)
The purpose of this study is to deploy and evaluate informational AI-Echo algorithms that assist echo clinicians in interpreting core echocardiographic parameters (e.g., LV/RV…
- Study
- Observational (registry, imaging)
- Sponsor
- Mayo Clinic
Recruiting in: United States
NCT07308704Updated 16 April 2026
RecruitingATTR (transthyretin)
NatiOnal Referral cenTEr Study of Transthyretin Amyloid Cardiomyopathy(ATTR) Patients on Tafamidis (opens on ClinicalTrials.gov)
All ATTRwt patients on tafamidis 61 mg treatment will be clinically evaluated before treatment initiation and subsequently every six months for the eligibility to…
- Study
- Observational (registry, imaging)
- Sponsor
- Paolo Milani
Recruiting in: Italy
NCT06251778Updated 16 April 2026
RecruitingAL (light chain)
Promoting Diagnosis and Management of AL in Italy (ProDigALIty) (opens on ClinicalTrials.gov)
The investigators plan to establish a dedicated network of Italian Hematologic Departments interconnected with the Amyloidosis Research and Treatment Center in Pavia to: 1.…
- Study
- Observational (registry, imaging)
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Recruiting in: Italy
NCT06383143Updated 16 April 2026
RecruitingATTR (transthyretin)
A Research Study to Look at the Distribution and Effects of Coramitug on Amyloid Deposits in Heart Tissue Using PET/CT Imaging in People With ATTR Amyloidosis. (opens on ClinicalTrials.gov)
The study is conducted in participants with Transthyretin Amyloid Cardiomyopathy (ATTR-CM), a heart disease that occurs in people with the disease ATTR amyloidosis. The…
- Study
- Interventional (treatment)
- Phase
- Phase 1
- Sponsor
- Novo Nordisk A/S
Recruiting in: Netherlands
NCT07448623Updated 13 April 2026
RecruitingATTR (transthyretin)
Characterizing Iodine-124 Evuzumitide (AT-01) in Systemic Amyloidosis (opens on ClinicalTrials.gov)
This is a single center prospective study evaluating 124I-evuzumitide in patients with systemic amyloidosis. The purpose of this study is to 1) Establish the…
- Study
- Interventional (treatment)
- Phase
- Phase 2
- Sponsor
- Oregon Health and Science University
Recruiting in: United States
NCT05758493Updated 13 April 2026
RecruitingATTR (transthyretin)
Phenotypic Manifestations of Hereditary ATTR Amyloidosis (opens on ClinicalTrials.gov)
This study focuses on hereditary transthyretin amyloidosis (ATTRv) with the Val50Met variant in a non endemic aerea
- Study
- Observational (registry, imaging)
- Sponsor
- Hospital 9 de Julio de Las Breñas
Recruiting in: Argentina
NCT07124377Updated 2 April 2026
This list only covers amyloidosis studies that are open or about to open. The registry holds every study, including those already completed.
Source: ClinicalTrials.gov (U.S. National Library of Medicine). List last retrieved on 25 September 2026. clinicaltrials.gov
Not sure where to start?
Our member associations know the teams running these studies in their own country, and can help you prepare the conversation with your doctor.