Research
Clinical trials
Every amyloidosis study now recruiting, about to open, or enrolling by invitation, anywhere in the world, listed straight from ClinicalTrials.gov and refreshed every day.
Information, not medical advice. The Alliance does not run these studies and cannot enrol you in one. If a trial looks relevant, discuss it with the doctor who follows your amyloidosis.
Recruiting and upcoming studies
The list covers AL, ATTR and AA amyloidosis as well as cerebral amyloid angiopathy. Each card says where the study stands: open to anyone who meets its criteria, not yet open, or restricted to people the investigators invite. Studies that close simply leave the list.
Showing 25–36 of 208 trials
RecruitingATTR (transthyretin)
ConTTRibute: A Global Observational Study of Patients With Transthyretin (TTR)-Mediated Amyloidosis (ATTR Amyloidosis) (opens on ClinicalTrials.gov)
The purpose of this study is to: * Describe epidemiological and clinical characteristics, natural history and real-world clinical management of ATTR amyloidosis patients *…
- Study
- Observational (registry, imaging)
- Sponsor
- Alnylam Pharmaceuticals
Recruiting in: BrazilBulgariaDenmarkFrance+8
NCT04561518Updated 8 September 2026
RecruitingNot specified
Pan-Amyloid PET/CT in Various Amyloid-Related Disease (opens on ClinicalTrials.gov)
To evaluate the potential usefulness of 18F-92/AV45/TPZA/FT8, 11C-PIB positron emission tomography/computed tomography (PET/CT) for the diagnosis of primary and metastatic lesions in various Pan-Amyloid-related…
- Study
- Observational (registry, imaging)
- Sponsor
- Tianjin Medical University
Recruiting in: China
NCT07130565Updated 8 September 2026
RecruitingATTR (transthyretin)
Patisiran-Lipid Nanoparticle (LNP) Pregnancy Surveillance Program (opens on ClinicalTrials.gov)
The purpose of this study is to collect and evaluate pregnancy outcomes, pregnancy complications, and fetal/neonatal/infant outcomes in women exposed to patisiran-LNP.
- Study
- Observational (registry, imaging)
- Sponsor
- Alnylam Pharmaceuticals
Recruiting in: FranceGermanyItalyNetherlands+3
NCT05040373Updated 8 September 2026
RecruitingNot specified
Echocardiographic Characterization of Cardiac Amyloidosis (opens on ClinicalTrials.gov)
This is a mono-center observational ambispective study in which patients with cardiac amyloidosis evaluated at the Fondazione Policlinico Universitario Agostino Gemelli IRCCS (Rome, Italy)…
- Study
- Observational (registry, imaging)
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Recruiting in: Italy
NCT05760287Updated 4 September 2026
Not yet recruitingATTR (transthyretin)
PET Imaging Study Using Evuzamitide to Detect Cardiac Amyloidosis in Patients With Inconclusive Nuclear Scans and Elevated TAD1 Levels (opens on ClinicalTrials.gov)
The goal of this study is to learn whether PET-CT imaging using evuzamitide can help diagnose transthyretin cardiac amyloidosis (ATTR-CA) in patients whose standard…
- Study
- Observational (registry, imaging)
- Sponsor
- Lorena Saelices
Recruiting in: United States
NCT07538518Updated 3 September 2026
RecruitingNot specified
Non-Interventional Study on the Prevalence of Cardiac Amyloidosis in Patients With Higher-Grade Aortic Valve Stenosis – Evaluation Using Echocardiography, Computed Tomography, Tc99-SPECT/CT and Cardiac Magnetic Resonance Imaging (CMR) (opens on ClinicalTrials.gov)
Degenerative aortic stenosis (AS) is frequently accompanied by left ventricular hypertrophy and diastolic dysfunction, features that overlap with transthyretin (ATTR) cardiac amyloidosis. Because concomitant…
- Study
- Observational (registry, imaging)
- Sponsor
- University Hospital Tuebingen
Recruiting in: Germany
NCT07752732Updated 2 September 2026
RecruitingCerebral amyloid angiopathy
Effect of the Mediterranean Diet in Patients Affected by CADASIL and Cerebral Amyloid Angiopathy. (opens on ClinicalTrials.gov)
The study is divided into two phases: Phase 1 (observational) and Phase 2 (dietary intervention). The goal of Phase 1 is to assess the…
- Study
- Observational (registry, imaging)
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Recruiting in: Italy
NCT06933212Updated 1 September 2026
RecruitingATTR (transthyretin)
Prevalence and Prediction of ATTR in Ambulatory Patients With HFpEF (opens on ClinicalTrials.gov)
Recent studies have shown that transthyretin amyloidosis (ATTR) can sometimes cause a type of heart failure where the pumping function of the heart is…
- Study
- Interventional (treatment)
- Sponsor
- Massachusetts General Hospital
Recruiting in: United States
NCT05577819Updated 1 September 2026
RecruitingATTR (transthyretin)
Subclinical Transthyretin Cardiac Amyloidosis in V122I TTR Carriers (opens on ClinicalTrials.gov)
Approximately 1.5 million of the 44 million Blacks in the United States are carriers of the valine-to-isoleucine substitution at position 122 (V122I) in the…
- Study
- Observational (registry, imaging)
- Sponsor
- University of Texas Southwestern Medical Center
Recruiting in: United States
NCT05489549Updated 31 August 2026
RecruitingAL (light chain)
A Study of JNJ-79635322 in Participants With Relapsed or Refractory Multiple Myeloma or Previously Treated Amyloid Light-chain (AL) Amyloidosis (opens on ClinicalTrials.gov)
The primary purpose of this study is to identify the recommended phase 2 dose (RP2D[s]) and schedule(s) to be safe for JNJ-79635322 in Part…
- Study
- Interventional (treatment)
- Phase
- Phase 1
- Sponsor
- Janssen Research & Development, LLC
Recruiting in: BelgiumFranceJapanNetherlands+3
NCT05652335Updated 28 August 2026
Not yet recruitingATTR (transthyretin)
An Open-Label Study to Evaluate the Long-Term Safety and Efficacy of ALXN2220 in Adults With Transthyretin Amyloid Cardiomyopathy (opens on ClinicalTrials.gov)
The purpose of Study ALXN2220-ATTRCM-302 is to evaluate the long-term safety, tolerability and efficacy of ALXN2220 in adult participants with ATTR-CM treated with ALXN2220…
- Study
- Interventional (treatment)
- Phase
- Phase 3
- Sponsor
- Alexion Pharmaceuticals, Inc.
Recruiting in: ArgentinaAustraliaAustriaBelgium+23
NCT07789483Updated 28 August 2026
RecruitingCerebral amyloid angiopathy
Application of Digital Twins’ Technology in Patients Who Had a Stroke, With Moyamoya Disease and With Cerebral Amyloid Angiopathy (CAA) During the Secondary Prevention Phase: A Proof of Concept Using a Randomized Control Trial (Clinical Study 6, STRATIF-AI Project) (opens on ClinicalTrials.gov)
The goal of this clinical trial is to obtain initial feedback on the implementation of the STRATIF-AI platform and digital twin in the secondary…
- Study
- Interventional (treatment)
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Recruiting in: Italy
NCT06714097Updated 28 August 2026
This list only covers amyloidosis studies that are open or about to open. The registry holds every study, including those already completed.
Source: ClinicalTrials.gov (U.S. National Library of Medicine). List last retrieved on 25 September 2026. clinicaltrials.gov
Not sure where to start?
Our member associations know the teams running these studies in their own country, and can help you prepare the conversation with your doctor.