{"id":5195,"date":"2023-06-28T08:23:00","date_gmt":"2023-06-28T06:23:00","guid":{"rendered":"https:\/\/www.amyloidosisalliance.org\/framsteg-inom-amyloidos\/"},"modified":"2026-11-03T10:46:24","modified_gmt":"2026-11-03T09:46:24","slug":"framsteg-inom-amyloidos","status":"publish","type":"post","link":"https:\/\/www.amyloidosisalliance.org\/sv\/framsteg-inom-amyloidos\/","title":{"rendered":"Framsteg inom amyloidos"},"content":{"rendered":"<\/p>\n\n\n<p class=\"wp-block-paragraph\">I n\u00e4stan 150 \u00e5r efter att den uppt\u00e4cktes ans\u00e5gs amyloidos vara obotlig. Historiskt sett bromsade sjukdomens komplexitet forskningen: varf\u00f6r l\u00e4gga tid och pengar p\u00e5 forskning om en s\u00e5 komplex sjukdom?<\/p>\n<p>\n<\/p><\/p>\n\n\n<p class=\"wp-block-paragraph\">Amyloidos \u00e4r n\u00e4mligen sv\u00e5r att diagnostisera av flera sk\u00e4l, bland annat f\u00f6r att det finns 36 k\u00e4nda undertyper. Elva av dem drabbar hj\u00e4rtat direkt, medan andra finns i andra delar av kroppen.<\/p>\n<p>\n<\/p><\/p>\n\n\n<p class=\"wp-block-paragraph\">Lyckligtvis f\u00f6r v\u00e5ra patienter har v\u00e5rden vid amyloidos utvecklats mycket till deras f\u00f6rdel under de senaste decennierna, p\u00e5 tre omr\u00e5den: diagnos, behandling och forskning.<\/p>\n<p>\n<\/p><\/p>\n\n\n<p class=\"wp-block-paragraph\">Artikeln bygger p\u00e5 studien: <a href=\"https:\/\/utswmed.org\/medblog\/cardiac-amyloidosis-doctor\/?fbclid=IwAR3jL4Ts9w6au4L9XCH9HFb0dWNg94G_2MQzQ76Ax23Tu22s9cC5nHcT2RQ\" target=\"_blank\" rel=\"noreferrer noopener\" style=\"font-family: var( --e-global-typography-text-font-family ), Sans-serif; font-weight: var( --e-global-typography-text-font-weight ); background-color: white; letter-spacing: 0.2px;\">Three parallel advances usher in new age of cardiac amyloidosis care<\/a>.<\/p>\n<p>\n<\/p><\/p>\n\n\n<h2 class=\"wp-block-heading\">Diagnos<\/h2>\n<p>\n<\/p><\/p>\n\n\n<p class=\"wp-block-paragraph\">Tidigare kr\u00e4vdes en endomyokardiell biopsi f\u00f6r att st\u00e4lla diagnosen ATTR-hj\u00e4rtamyloidos (ATTR-CA). Nu g\u00f6r framstegen inom diagnostisk teknik det m\u00f6jligt att bekr\u00e4fta ATTR-amyloidos, n\u00e4r AL-amyloidos har uteslutits, p\u00e5 olika s\u00e4tt, bland annat med bilddiagnostik och blod- och urinprov.<\/p>\n<p>\n<\/p><\/p>\n\n\n<p class=\"wp-block-paragraph\">Det f\u00f6rsta steget i diagnostiken \u00e4r att leta efter onormala l\u00e4tta kedjor. F\u00f6r att p\u00e5visa s\u00e5dana avvikelser kan redan ett blodprov signalera att diagnosen \u00e4r br\u00e5dskande. Tekniker som EKG och ekokardiografi kan tillsammans ge riktigt starka bel\u00e4gg f\u00f6r hj\u00e4rtamyloidos. F\u00f6rst n\u00e4r AL-amyloidos inte kan uteslutas b\u00f6r en endomyokardiell biopsi g\u00f6ras f\u00f6r att p\u00e5visa sjukdomen. N\u00e4r AL-amyloidos d\u00e4remot har uteslutits kan andra unders\u00f6kningar g\u00f6ras, till exempel skintigrafi, blod- och urinprov eller magnetkameraunders\u00f6kning av hj\u00e4rtat.<\/p>\n<p>\n<\/p><\/p>\n\n\n<h2 class=\"wp-block-heading\">Behandling<\/h2>\n<p>\n<\/p><\/p>\n\n\n<p class=\"wp-block-paragraph\">F\u00f6r b\u00e4sta m\u00f6jliga behandlingsresultat vid amyloidos \u00e4r tidig behandling och samordnad v\u00e5rd avg\u00f6rande. Vissa sjukhus har omfattande resurser och specialiserade l\u00e4kare f\u00f6r att f\u00f6rs\u00f6ka besegra sjukdomen.<\/p>\n<p>\n<\/p><\/p>\n\n\n<p class=\"wp-block-paragraph\">Bland de effektiva behandlingskombinationer som finns i dag ing\u00e5r en kombination av cytostatika och monoklonala antikroppar, som CyBorD och daratumumab. Vissa nya l\u00e4kemedel har ocks\u00e5 gjort det m\u00f6jligt att stabilisera sjukdomen hos en del patienter. Till exempel godk\u00e4nde FDA inotersen och patisiran 2018 f\u00f6r \u00e4rftlig ATTR-amyloidos, och tafamidis 2019. Den h\u00e4r typen av behandling botar naturligtvis inte sjukdomen, men den bromsar den och minskar risken f\u00f6r sjukhusv\u00e5rd eller d\u00f6d.<\/p>\n<p>\n<\/p><\/p>\n\n\n<h2 class=\"wp-block-heading\">Forskning<\/h2>\n<p>\n<\/p><\/p>\n\n\n<p class=\"wp-block-paragraph\">Efter m\u00e5nga \u00e5r med n\u00e4stan ingen forskning om amyloidos kan vi nu s\u00e4ga att forskningen blomstrar.<\/p>\n<p>\n<\/p><\/p>\n\n\n<p class=\"wp-block-paragraph\">Allt fler kliniska pr\u00f6vningar genomf\u00f6rs f\u00f6r att l\u00e4ra sig mer om sjukdomen och kunna besegra den. Bland de mest uppm\u00e4rksammade finns:<\/p>\n<p>\n<\/p><\/p>\n\n<\/p>\n<ul class=\"wp-block-list\">\n<li style=\"list-style-type: none;\">\n<ul>\n\n\n\n\n<ul>\n<li style=\"list-style-type: none;\">\n<ul>\n<li>Studie av den monoklonala antikroppen CAEL-101<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>\n<\/p>\n<\/p>\n<p>\n\n\n<ul>\n<li style=\"list-style-type: none;\">\n<ul>\n<li>Cardio TTRANSFORM<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>\n<\/p>\n<\/p>\n<p>\n\n\n<ul>\n<li style=\"list-style-type: none;\">\n<ul>\n<li>S\u00e4kerhet, effekt och farmakokinetik f\u00f6r tafamidis<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>\n<\/p>\n<\/p>\n<p>\n<\/p>\n\n\n<p class=\"wp-block-paragraph\">Denna nya era f\u00f6r amyloidos ger patienterna hopp. Vi hoppas att den l\u00e5nga v\u00e4gen till diagnos i framtiden ska vara ett minne blott och att vi ska kunna l\u00e4sa om allt effektivare behandlingar mot amyloidos.<\/p>\n<p>\n<\/p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Diagnos, behandling och forskning: hur v\u00e5rden vid hj\u00e4rtamyloidos har utvecklats under de senaste decennierna, utifr\u00e5n en genomg\u00e5ng av tre parallella framsteg.<\/p>\n","protected":false},"author":1,"featured_media":5196,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[93],"tags":[],"class_list":["post-5195","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized-sv"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Framsteg inom amyloidos<\/title>\n<meta name=\"description\" content=\"Diagnos, behandling och forskning: hur v\u00e5rden vid hj\u00e4rtamyloidos har utvecklats under de senaste decennierna, utifr\u00e5n en genomg\u00e5ng av tre parallella framsteg.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" 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