{"id":4961,"date":"2023-06-28T08:23:00","date_gmt":"2023-06-28T06:23:00","guid":{"rendered":"https:\/\/www.amyloidosisalliance.org\/os-progressos-na-amiloidose\/"},"modified":"2026-11-03T10:41:32","modified_gmt":"2026-11-03T09:41:32","slug":"os-progressos-na-amiloidose","status":"publish","type":"post","link":"https:\/\/www.amyloidosisalliance.org\/pt\/os-progressos-na-amiloidose\/","title":{"rendered":"Os progressos na amiloidose"},"content":{"rendered":"<\/p>\n\n\n<p class=\"wp-block-paragraph\">Durante quase 150 anos ap\u00f3s a sua descoberta, a amiloidose foi considerada incur\u00e1vel. Historicamente, a complexidade da doen\u00e7a atrasou a investiga\u00e7\u00e3o: porqu\u00ea investir tempo e dinheiro na investiga\u00e7\u00e3o de uma doen\u00e7a t\u00e3o complexa?<\/p>\n<p>\n<\/p><\/p>\n\n\n<p class=\"wp-block-paragraph\">A amiloidose \u00e9, de facto, dif\u00edcil de diagnosticar por v\u00e1rias raz\u00f5es, nomeadamente porque existem 36 subtipos conhecidos. Onze deles afetam diretamente o cora\u00e7\u00e3o, enquanto outros se encontram noutras partes do corpo.<\/p>\n<p>\n<\/p><\/p>\n\n\n<p class=\"wp-block-paragraph\">Felizmente para os nossos doentes, o acompanhamento da amiloidose evoluiu muito a seu favor nas \u00faltimas d\u00e9cadas, em tr\u00eas frentes: o diagn\u00f3stico, o tratamento e a investiga\u00e7\u00e3o.<\/p>\n<p>\n<\/p><\/p>\n\n\n<p class=\"wp-block-paragraph\">Este artigo baseia-se no estudo: <a href=\"https:\/\/utswmed.org\/medblog\/cardiac-amyloidosis-doctor\/?fbclid=IwAR3jL4Ts9w6au4L9XCH9HFb0dWNg94G_2MQzQ76Ax23Tu22s9cC5nHcT2RQ\" target=\"_blank\" rel=\"noreferrer noopener\" style=\"font-family: var( --e-global-typography-text-font-family ), Sans-serif; font-weight: var( --e-global-typography-text-font-weight ); background-color: white; letter-spacing: 0.2px;\">Three parallel advances usher in new age of cardiac amyloidosis care<\/a>.<\/p>\n<p>\n<\/p><\/p>\n\n\n<h2 class=\"wp-block-heading\">O diagn\u00f3stico<\/h2>\n<p>\n<\/p><\/p>\n\n\n<p class=\"wp-block-paragraph\">At\u00e9 agora, o diagn\u00f3stico da amiloidose card\u00edaca ATTR (ATTR-CA) exigia uma bi\u00f3psia endomioc\u00e1rdica. Hoje, os progressos das tecnologias de diagn\u00f3stico permitem confirmar uma amiloidose ATTR, depois de exclu\u00edda a amiloidose AL, por diferentes meios, incluindo a imagiologia e as an\u00e1lises ao sangue e \u00e0 urina.<\/p>\n<p>\n<\/p><\/p>\n\n\n<p class=\"wp-block-paragraph\">A primeira etapa do diagn\u00f3stico \u00e9 a pesquisa de cadeias leves anormais. Para revelar estas anomalias, uma an\u00e1lise ao sangue pode desde logo assinalar uma urg\u00eancia diagn\u00f3stica. Tecnologias como o eletrocardiograma ou o ecocardiograma, combinadas, podem trazer provas realmente s\u00f3lidas de amiloidose card\u00edaca. S\u00f3 quando a amiloidose AL n\u00e3o pode ser exclu\u00edda se deve recorrer a uma bi\u00f3psia endomioc\u00e1rdica para detetar a doen\u00e7a. Quando a amiloidose AL \u00e9 exclu\u00edda, podem ser feitos outros exames, como a cintigrafia, as an\u00e1lises ao sangue e \u00e0 urina ou a resson\u00e2ncia magn\u00e9tica card\u00edaca.<\/p>\n<p>\n<\/p><\/p>\n\n\n<h2 class=\"wp-block-heading\">Tratamento<\/h2>\n<p>\n<\/p><\/p>\n\n\n<p class=\"wp-block-paragraph\">Para obter os melhores resultados no tratamento da amiloidose, um tratamento precoce e um acompanhamento coordenado s\u00e3o essenciais. Alguns hospitais disp\u00f5em de equipamentos importantes e de m\u00e9dicos especializados para tentar vencer esta doen\u00e7a.<\/p>\n<p>\n<\/p><\/p>\n\n\n<p class=\"wp-block-paragraph\">Entre as associa\u00e7\u00f5es de tratamentos eficazes que existem hoje est\u00e1 a associa\u00e7\u00e3o de quimioterapia e anticorpos monoclonais, como o CyBorD e o daratumumab. O aparecimento de certos medicamentos tamb\u00e9m permitiu estabilizar a doen\u00e7a em alguns doentes. Por exemplo, a FDA aprovou o inotersen e o patisiran em 2018 para a amiloidose ATTR heredit\u00e1ria e, em 2019, o tafamidis. Este tipo de tratamento n\u00e3o cura, evidentemente, a doen\u00e7a, mas abranda-a e reduz o risco de hospitaliza\u00e7\u00e3o ou de morte.<\/p>\n<p>\n<\/p><\/p>\n\n\n<h2 class=\"wp-block-heading\">Investiga\u00e7\u00e3o<\/h2>\n<p>\n<\/p><\/p>\n\n\n<p class=\"wp-block-paragraph\">Depois de anos quase sem investiga\u00e7\u00e3o sobre a amiloidose, podemos dizer hoje que est\u00e1 em plena expans\u00e3o.<\/p>\n<p>\n<\/p><\/p>\n\n\n<p class=\"wp-block-paragraph\">S\u00e3o realizados cada vez mais ensaios cl\u00ednicos para conhecer melhor a doen\u00e7a e conseguir venc\u00ea-la. Entre os mais marcantes:<\/p>\n<p>\n<\/p><\/p>\n\n<\/p>\n<ul class=\"wp-block-list\">\n<li style=\"list-style-type: none;\">\n<ul>\n\n\n\n\n<ul>\n<li style=\"list-style-type: none;\">\n<ul>\n<li>Estudo do anticorpo monoclonal CAEL-101<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>\n<\/p>\n<\/p>\n<p>\n\n\n<ul>\n<li style=\"list-style-type: none;\">\n<ul>\n<li>Cardio TTRANSFORM<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>\n<\/p>\n<\/p>\n<p>\n\n\n<ul>\n<li style=\"list-style-type: none;\">\n<ul>\n<li>Seguran\u00e7a, efic\u00e1cia e farmacocin\u00e9tica do tafamidis<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>\n<\/p>\n<\/p>\n<p>\n<\/p>\n\n\n<p class=\"wp-block-paragraph\">Esta nova era da amiloidose traz esperan\u00e7a aos doentes. Esperamos que, no futuro, a err\u00e2ncia diagn\u00f3stica fique para tr\u00e1s e que possamos conhecer tratamentos cada vez mais eficazes contra a amiloidose.<\/p>\n<p>\n<\/p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Diagn\u00f3stico, tratamento e investiga\u00e7\u00e3o: como evoluiu o acompanhamento da amiloidose card\u00edaca nas \u00faltimas d\u00e9cadas, com base numa an\u00e1lise de tr\u00eas avan\u00e7os paralelos.<\/p>\n","protected":false},"author":1,"featured_media":4962,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[83],"tags":[],"class_list":["post-4961","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized-pt-pt"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Os progressos na amiloidose<\/title>\n<meta name=\"description\" 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