{"id":3695,"date":"2026-07-07T14:51:22","date_gmt":"2026-07-07T12:51:22","guid":{"rendered":"https:\/\/www.amyloidosisalliance.org\/soorten-amyloidose\/"},"modified":"2026-11-03T08:41:37","modified_gmt":"2026-11-03T07:41:37","slug":"soorten-amyloidose","status":"publish","type":"page","link":"https:\/\/www.amyloidosisalliance.org\/nl\/soorten-amyloidose\/","title":{"rendered":"Soorten amylo\u00efdose"},"content":{"rendered":"\n<nav aria-label=\"Breadcrumb\" class=\"wp-block-group aa-breadcrumb is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"aa-inner\"><a href=\"\/\">Home<\/a><span class=\"aa-breadcrumb__sep\">\u203a<\/span><span class=\"aa-breadcrumb__label\">Amylo\u00efdose<\/span><span class=\"aa-breadcrumb__sep\">\u203a<\/span><span class=\"aa-breadcrumb__current\">Soorten amylo\u00efdose<\/span><\/div>\n<\/nav>\n\n<section class=\"wp-block-group aa-page-hero is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-inner is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-page-hero__grid is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"aa-overline wp-block-paragraph\">Amylo\u00efdose<\/p>\n\n\n\n<h1 class=\"wp-block-heading\">Soorten amylo\u00efdose<\/h1>\n\n\n\n<p class=\"aa-lead wp-block-paragraph\">Amylo\u00efdose is niet \u00e9\u00e9n ziekte, maar een familie van afzonderlijke aandoeningen, elk bepaald door het soort eiwit dat verkeerd vouwt en door de organen die het aantast. Inzicht in elke soort is de eerste stap naar een nauwkeurige diagnose en een gerichte behandeling.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-page-hero__photo is-layout-flow wp-block-group-is-layout-flow\">\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"1080\" height=\"1350\" src=\"https:\/\/www.amyloidosisalliance.org\/wp-content\/uploads\/2026\/09\/Design-sans-titre.zip-6.jpg\" alt=\"\" class=\"wp-image-1190\" srcset=\"https:\/\/www.amyloidosisalliance.org\/wp-content\/uploads\/2026\/09\/Design-sans-titre.zip-6.jpg 1080w, https:\/\/www.amyloidosisalliance.org\/wp-content\/uploads\/2026\/09\/Design-sans-titre.zip-6-240x300.jpg 240w, https:\/\/www.amyloidosisalliance.org\/wp-content\/uploads\/2026\/09\/Design-sans-titre.zip-6-819x1024.jpg 819w, https:\/\/www.amyloidosisalliance.org\/wp-content\/uploads\/2026\/09\/Design-sans-titre.zip-6-768x960.jpg 768w\" sizes=\"auto, (max-width: 1080px) 100vw, 1080px\" \/><\/figure>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n\n<nav aria-label=\"Section navigation\" class=\"wp-block-group aa-anchorband is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-inner is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-columns aa-anchor-cols is-layout-flex wp-container-core-columns-is-layout-b2e659ba wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column aa-anchor-item is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"num wp-block-paragraph\">01<\/p>\n\n\n\n<p class=\"lbl wp-block-paragraph\"><a href=\"#diversity\">De diversiteit<\/a><\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column aa-anchor-item is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"num wp-block-paragraph\">02<\/p>\n\n\n\n<p class=\"lbl wp-block-paragraph\"><a href=\"#al\">AL-amylo\u00efdose<\/a><\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column aa-anchor-item is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"num wp-block-paragraph\">03<\/p>\n\n\n\n<p class=\"lbl wp-block-paragraph\"><a href=\"#attr\">ATTR-amylo\u00efdose<\/a><\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column aa-anchor-item is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"num wp-block-paragraph\">04<\/p>\n\n\n\n<p class=\"lbl wp-block-paragraph\"><a href=\"#aa\">AA-amylo\u00efdose<\/a><\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column aa-anchor-item is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"num wp-block-paragraph\">05<\/p>\n\n\n\n<p class=\"lbl wp-block-paragraph\"><a href=\"#rarer\">Zeldzamere soorten<\/a><\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column aa-anchor-item is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"num wp-block-paragraph\">06<\/p>\n\n\n\n<p class=\"lbl wp-block-paragraph\"><a href=\"#localized\">Gelokaliseerd<\/a><\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column aa-anchor-item is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"num wp-block-paragraph\">07<\/p>\n\n\n\n<p class=\"lbl wp-block-paragraph\"><a href=\"#compare\">Soorten vergelijken<\/a><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/nav>\n\n<section id=\"diversity\" class=\"wp-block-group aa-section aa-section--white aa-intro is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-inner is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"aa-section-num wp-block-paragraph\">01<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">De grote diversiteit van amylo\u00efdose<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Van meer dan 40 menselijke precursoreiwitten is bekend dat ze amylo\u00efde afzettingen kunnen vormen. Amylo\u00efdose wordt ingedeeld naar het eiwit dat de fibrillen vormt. Bij de meest voorkomende systemische vormen, AL, ATTR en AA, zijn telkens andere precursoreiwitten betrokken, worden andere organen aangetast en zijn fundamenteel verschillende behandelstrategie\u00ebn nodig.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Omdat de symptomen vaak lijken op die van veel voorkomende ziekten, is een correcte typering essentieel; daarvoor zijn gespecialiseerde onderzoeken nodig. Een vroege en nauwkeurige typering is de basis van goede zorg.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-intro__media is-layout-flow wp-block-group-is-layout-flow\">\n<figure class=\"aa-protein\" role=\"img\" aria-label=\"Illustratie: een correct gevouwen eiwit vouwt verkeerd en stapelt zich op tot amylo\u00efde fibrillen\">\n\t\t\t\t<svg viewbox=\"0 0 480 360\" aria-hidden=\"true\" focusable=\"false\">\n\t\t\t\t\t<defs>\n\t\t\t\t\t\t<lineargradient id=\"aa-prot-core\" x1=\"0\" y1=\"0\" x2=\"1\" y2=\"1\">\n\t\t\t\t\t\t\t<stop offset=\"0%\" stop-color=\"#167a82\"><\/stop>\n\t\t\t\t\t\t\t<stop offset=\"100%\" stop-color=\"#00666d\"><\/stop>\n\t\t\t\t\t\t<\/lineargradient>\n\t\t\t\t\t\t<lineargradient id=\"aa-prot-fib\" x1=\"0\" y1=\"0\" x2=\"1\" y2=\"0\">\n\t\t\t\t\t\t\t<stop offset=\"0%\" stop-color=\"#f6a955\"><\/stop>\n\t\t\t\t\t\t\t<stop offset=\"100%\" stop-color=\"#f39325\"><\/stop>\n\t\t\t\t\t\t<\/lineargradient>\n\t\t\t\t\t<\/defs>\n\n\t\t\t\t\t<!-- Prot\u00e9ine correctement repli\u00e9e : h\u00e9lice compacte -->\n\t\t\t\t\t<g transform=\"translate(96 130)\">\n\t\t\t\t\t\t<circle r=\"62\" fill=\"#eaf3f3\"><\/circle>\n\t\t\t\t\t\t<path d=\"M-34 26 C-46 2 -26 -14 -6 -8 C14 -2 30 -16 22 -34\" fill=\"none\" stroke=\"url(#aa-prot-core)\" stroke-width=\"9\" stroke-linecap=\"round\"><\/path>\n\t\t\t\t\t\t<path d=\"M-26 40 C-4 44 18 30 26 10\" fill=\"none\" stroke=\"url(#aa-prot-core)\" stroke-width=\"9\" stroke-linecap=\"round\" opacity=\"0.55\"><\/path>\n\t\t\t\t\t\t<circle cx=\"22\" cy=\"-34\" r=\"7\" fill=\"#00666d\"><\/circle>\n\t\t\t\t\t\t<circle cx=\"-34\" cy=\"26\" r=\"7\" fill=\"#00666d\"><\/circle>\n\t\t\t\t\t<\/g>\n\n\t\t\t\t\t<!-- Transition -->\n\t\t\t\t\t<g stroke=\"#c9d2d6\" stroke-width=\"2\" stroke-linecap=\"round\">\n\t\t\t\t\t\t<line x1=\"176\" y1=\"130\" x2=\"212\" y2=\"130\" stroke-dasharray=\"2 8\"><\/line>\n\t\t\t\t\t\t<path d=\"M206 122 L216 130 L206 138\" fill=\"none\"><\/path>\n\t\t\t\t\t<\/g>\n\n\t\t\t\t\t<!-- Prot\u00e9ine mal repli\u00e9e : feuillets b\u00eata empil\u00e9s -->\n\t\t\t\t\t<g transform=\"translate(300 130)\">\n\t\t\t\t\t\t<g fill=\"none\" stroke=\"url(#aa-prot-fib)\" stroke-width=\"8\" stroke-linecap=\"round\">\n\t\t\t\t\t\t\t<path d=\"M-56 -34 L-20 -34 L-20 -14 L16 -14 L16 -34 L52 -34\"><\/path>\n\t\t\t\t\t\t\t<path d=\"M-56 -6 L-20 -6 L-20 14 L16 14 L16 -6 L52 -6\"><\/path>\n\t\t\t\t\t\t\t<path d=\"M-56 22 L-20 22 L-20 42 L16 42 L16 22 L52 22\"><\/path>\n\t\t\t\t\t\t<\/g>\n\t\t\t\t\t<\/g>\n\n\t\t\t\t\t<!-- Fibrille amylo\u00efde : les feuillets s'assemblent en filament -->\n\t\t\t\t\t<g transform=\"translate(240 268)\" fill=\"none\" stroke-linecap=\"round\">\n\t\t\t\t\t\t<path d=\"M-190 0 C-150 -22 -110 22 -70 0 C-30 -22 10 22 50 0 C90 -22 130 22 170 0\" stroke=\"url(#aa-prot-fib)\" stroke-width=\"7\"><\/path>\n\t\t\t\t\t\t<path d=\"M-190 14 C-150 -8 -110 36 -70 14 C-30 -8 10 36 50 14 C90 -8 130 36 170 14\" stroke=\"url(#aa-prot-fib)\" stroke-width=\"7\" opacity=\"0.45\"><\/path>\n\t\t\t\t\t<\/g>\n\n\t\t\t\t\t<text x=\"96\" y=\"222\" text-anchor=\"middle\" fill=\"#5a6a73\" font-family=\"'JetBrains Mono', ui-monospace, monospace\" font-size=\"12\" letter-spacing=\"1.4\">GEVOUWEN<\/text>\n\t\t\t\t\t<text x=\"300\" y=\"222\" text-anchor=\"middle\" fill=\"#5a6a73\" font-family=\"'JetBrains Mono', ui-monospace, monospace\" font-size=\"12\" letter-spacing=\"1.4\">VERKEERD GEVOUWEN<\/text>\n\t\t\t\t\t<text x=\"240\" y=\"320\" text-anchor=\"middle\" fill=\"#5a6a73\" font-family=\"'JetBrains Mono', ui-monospace, monospace\" font-size=\"12\" letter-spacing=\"1.4\">AMYLO\u00cfDE FIBRIL<\/text>\n\t\t\t\t<\/svg>\n\t\t\t<\/figure>\n<\/div>\n<\/div>\n<\/section>\n\n<section id=\"al\" class=\"wp-block-group aa-section aa-section--cream aa-type is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-inner is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-type-split aa-type-split--photo-left is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-type-photo is-layout-flow wp-block-group-is-layout-flow\">\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" src=\"\/wp-content\/themes\/amyloidosis-alliance\/assets\/images\/disease\/al-card.svg\" alt=\"\"\/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-type-text is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"aa-type-label wp-block-paragraph\">02 \u00b7 Systemisch<\/p>\n\n\n\n<h2 class=\"wp-block-heading aa-type-h\">AL-amylo\u00efdose<\/h2>\n\n\n\n<p class=\"aa-type-p wp-block-paragraph\">AL-amylo\u00efdose (lichte ketens) wordt veroorzaakt door een abnormale woekering van plasmacellen in het beenmerg die verkeerd gevouwen lichte ketens van immunoglobulinen aanmaken. Deze fragmenten zetten zich af als amylo\u00efde fibrillen, vooral in het hart en de nieren, maar mogelijk in elk orgaan.<\/p>\n\n\n\n<p class=\"aa-type-p wp-block-paragraph\">Het is de meest voorkomende vorm van systemische amylo\u00efdose in ontwikkelde landen. De behandeling richt zich op de onderliggende plasmacelaandoening, meestal met chemotherapieschema\u2019s die vergelijkbaar zijn met die bij multipel myeloom.<\/p>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button aa-btn aa-btn--teal\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.amyloidosisalliance.org\/nl\/soorten-amyloidose\/al-amyloidose\/\">Ontdek AL-amylo\u00efdose \u2192<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n\n<section id=\"attr\" class=\"wp-block-group aa-section aa-section--white aa-type is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-inner is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-type-split aa-type-split--photo-right is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"aa-section-num wp-block-paragraph\">03 \u00b7 Systemisch<\/p>\n\n\n\n<h2 class=\"wp-block-heading aa-type-h\">ATTR-amylo\u00efdose<\/h2>\n\n\n\n<p class=\"aa-type-p wp-block-paragraph\">ATTR-amylo\u00efdose (transthyretine) ontstaat wanneer transthyretine, een eiwit dat door de lever wordt aangemaakt, instabiel wordt en verkeerd vouwt. Ze tast vooral het hart en het perifere zenuwstelsel aan en bestaat in twee afzonderlijke vormen, met verschillende oorzaken en behandeltrajecten.<\/p>\n\n\n\n<div class=\"wp-block-group aa-subtype-list is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-subtype-row is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"aa-subtype-row__name wp-block-paragraph\">Wild-type ATTR<\/p>\n\n\n\n<p class=\"aa-subtype-row__desc wp-block-paragraph\">Ontstaat spontaan met het ouder worden en is niet erfelijk. Uit zich meestal als cardiomyopathie bij oudere mannen. Wordt steeds vaker herkend dankzij betere beeldvorming van het hart.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button aa-btn aa-btn--teal aa-btn--sm\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.amyloidosisalliance.org\/nl\/soorten-amyloidose\/attrwt-amyloidose\/\">Ontdek \u2192<\/a><\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-subtype-row is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"aa-subtype-row__name wp-block-paragraph\">Erfelijke ATTR<\/p>\n\n\n\n<p class=\"aa-subtype-row__desc wp-block-paragraph\">Veroorzaakt door een genetische mutatie in het TTR-gen. Erft autosomaal dominant over. De leeftijd waarop de ziekte begint en de aangetaste organen verschillen per mutatie; neuropathie is een kenmerkend symptoom.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button aa-btn aa-btn--teal aa-btn--sm\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.amyloidosisalliance.org\/nl\/soorten-amyloidose\/attrv-amyloidose\/\">Ontdek \u2192<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-type-photo is-layout-flow wp-block-group-is-layout-flow\">\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" src=\"\/wp-content\/themes\/amyloidosis-alliance\/assets\/images\/disease\/attr-card.svg\" alt=\"\"\/><\/figure>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n\n<section id=\"aa\" class=\"wp-block-group aa-section aa-section--cream aa-type is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-inner is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-type-split aa-type-split--photo-left is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-type-photo is-layout-flow wp-block-group-is-layout-flow\">\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" src=\"\/wp-content\/themes\/amyloidosis-alliance\/assets\/images\/disease\/aa-card.svg\" alt=\"\"\/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-type-text is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"aa-type-label wp-block-paragraph\">04 \u00b7 Systemisch<\/p>\n\n\n\n<h2 class=\"wp-block-heading aa-type-h\">AA-amylo\u00efdose<\/h2>\n\n\n\n<p class=\"aa-type-p wp-block-paragraph\">AA-amylo\u00efdose ontstaat als secundaire complicatie van aanhoudende systemische ontsteking. Het verantwoordelijke eiwit, serum-amylo\u00efd A (SAA), is een acutefase-eiwit dat de lever aanmaakt als reactie op chronische ontstekingstoestanden zoals reumato\u00efde artritis, chronische darmontstekingen of chronische infecties.<\/p>\n\n\n\n<p class=\"aa-type-p wp-block-paragraph\">De nieren zijn het belangrijkste doelwit, met prote\u00efnurie en progressief nierfalen tot gevolg. De behandeling is erop gericht de onderliggende ontstekings- of infectieziekte onder controle te brengen en de aanmaak van serum-amylo\u00efd A (SAA) te onderdrukken.<\/p>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button aa-btn aa-btn--teal\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.amyloidosisalliance.org\/nl\/soorten-amyloidose\/aa-amyloidose\/\">Ontdek AA-amylo\u00efdose \u2192<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n\n<section id=\"rarer\" class=\"wp-block-group aa-section aa-section--white aa-type is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-inner is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-type-split aa-type-split--photo-right is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"aa-section-num wp-block-paragraph\">05<\/p>\n\n\n\n<h2 class=\"wp-block-heading aa-type-h\">Zeldzamere erfelijke soorten<\/h2>\n\n\n\n<p class=\"aa-type-p wp-block-paragraph\">Naast ATTR veroorzaken nog andere genmutaties zeldzamere erfelijke vormen van systemische amylo\u00efdose. Elke vorm wordt bepaald door het precursoreiwit en heeft een eigen patroon van orgaanbetrokkenheid. Genetisch onderzoek is onmisbaar voor de diagnose en heeft gevolgen voor familieleden.<\/p>\n\n\n\n<div class=\"wp-block-group aa-subtype-list is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-rare-row is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"aa-rare-row__name wp-block-paragraph\">AAPOA1<\/p>\n\n\n\n<p class=\"aa-rare-row__desc wp-block-paragraph\">Mutatie van apolipoprote\u00efne A-I. Tast de nieren, de lever en de perifere zenuwen aan. Autosomaal dominante overerving.<\/p>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button aa-btn aa-btn--teal aa-btn--sm\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.amyloidosisalliance.org\/nl\/soorten-amyloidose\/zeldzame-erfelijke-amyloidosen\/\">Ontdek \u2192<\/a><\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-rare-row is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"aa-rare-row__name wp-block-paragraph\">AGEL<\/p>\n\n\n\n<p class=\"aa-rare-row__desc wp-block-paragraph\">Mutatie in gelsoline. Veroorzaakt vooral craniale neuropathie en lattice-dystrofie van het hoornvlies. Komt het meest voor in Finland.<\/p>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button aa-btn aa-btn--teal aa-btn--sm\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.amyloidosisalliance.org\/nl\/soorten-amyloidose\/zeldzame-erfelijke-amyloidosen\/\">Ontdek \u2192<\/a><\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-rare-row is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"aa-rare-row__name wp-block-paragraph\">ALYS<\/p>\n\n\n\n<p class=\"aa-rare-row__desc wp-block-paragraph\">Mutatie van lysozym. Vooral betrokkenheid van de nieren, met afzettingen in de lever. Historisch zijn Britse gevallen beschreven.<\/p>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button aa-btn aa-btn--teal aa-btn--sm\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.amyloidosisalliance.org\/nl\/soorten-amyloidose\/zeldzame-erfelijke-amyloidosen\/\">Ontdek \u2192<\/a><\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-rare-row is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"aa-rare-row__name wp-block-paragraph\">AFib<\/p>\n\n\n\n<p class=\"aa-rare-row__desc wp-block-paragraph\">Mutatie van de alfaketen van fibrinogeen. Uitsluitend een nierziekte; een van de vaker voorkomende erfelijke vormen in West-Europa.<\/p>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button aa-btn aa-btn--teal aa-btn--sm\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.amyloidosisalliance.org\/nl\/soorten-amyloidose\/zeldzame-erfelijke-amyloidosen\/\">Ontdek \u2192<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-type-photo is-layout-flow wp-block-group-is-layout-flow\">\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" src=\"\/wp-content\/themes\/amyloidosis-alliance\/assets\/images\/disease\/rare-card.svg\" alt=\"\"\/><\/figure>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n\n<section id=\"localized\" class=\"wp-block-group aa-section aa-section--forest aa-type is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-inner is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-type-split aa-type-split--photo-left is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-type-photo is-layout-flow wp-block-group-is-layout-flow\">\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" src=\"\/wp-content\/themes\/amyloidosis-alliance\/assets\/images\/disease\/localised-card.svg\" alt=\"\"\/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-type-text is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"aa-type-label wp-block-paragraph\">06 \u00b7 Gelokaliseerd<\/p>\n\n\n\n<h2 class=\"wp-block-heading aa-type-h\">Gelokaliseerde amylo\u00efdose<\/h2>\n\n\n\n<p class=\"aa-type-p wp-block-paragraph\">Anders dan bij de systemische vormen blijft gelokaliseerde amylo\u00efdose beperkt tot \u00e9\u00e9n orgaan of weefsel, meestal de luchtwegen, de huid, de blaas of de oogkas. Het amylo\u00efd wordt ter plaatse aangemaakt door plasmacellen in het weefsel en verspreidt zich niet door het lichaam.<\/p>\n\n\n\n<p class=\"aa-type-p wp-block-paragraph\">De prognose is over het algemeen gunstiger dan bij systemische ziekte, omdat de werking van vitale organen zelden in gevaar komt. De aanpak hangt af van de plaats van de aandoening en de omvang van de lokale weefselschade.<\/p>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button aa-btn aa-btn--primary\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.amyloidosisalliance.org\/nl\/soorten-amyloidose\/gelokaliseerde-amyloidose\/\">Ontdek \u2192<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n\n<section id=\"compare\" class=\"wp-block-group aa-section aa-section--cream aa-compare-sec is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-inner is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-centered-head is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"aa-section-num wp-block-paragraph\">07<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Soorten vergelijken<\/h2>\n\n\n\n<div class=\"aa-divider-dot\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">Een beknopt overzicht van de belangrijkste soorten amylo\u00efdose: eiwit, voornaamste aangetaste organen, behandelaanpak en waar u meer informatie vindt.<\/p>\n<\/div>\n\n\n\n<figure class=\"wp-block-table aa-compare\"><table><thead><tr><th>Soort<\/th><th>Eiwit<\/th><th>Voornaamste organen<\/th><th>Behandelaanpak<\/th><th>Meer informatie<\/th><\/tr><\/thead><tbody><tr><td>AL<\/td><td>Lichte ketens van immunoglobulinen<\/td><td>Hart, nieren, lever, zenuwen, weke delen<\/td><td>Chemotherapie gericht op de plasmacellen; stamceltransplantatie bij pati\u00ebnten die daarvoor in aanmerking komen<\/td><td><a class=\"aa-compare__link\" href=\"https:\/\/www.amyloidosisalliance.org\/nl\/soorten-amyloidose\/al-amyloidose\/\">AL-amylo\u00efdose \u2192<\/a><\/td><\/tr><tr><td>ATTR, wild-type<\/td><td>Transthyretine (wild-type)<\/td><td>Hart (cardiomyopathie)<\/td><td>Stabilisatie van TTR en ondersteunende hartzorg; goedgekeurde indicaties en beschikbaarheid verschillen per land.<\/td><td><a class=\"aa-compare__link\" href=\"https:\/\/www.amyloidosisalliance.org\/nl\/soorten-amyloidose\/attrwt-amyloidose\/\">ATTRwt-amylo\u00efdose \u2192<\/a><\/td><\/tr><tr><td>ATTR, erfelijk<\/td><td>Transthyretine (gemuteerd)<\/td><td>Perifere zenuwen, hart (afhankelijk van de mutatie)<\/td><td>TTR-silencers (siRNA, ASO); stabilisatoren; levertransplantatie (bij bepaalde mutaties)<\/td><td><a class=\"aa-compare__link\" href=\"https:\/\/www.amyloidosisalliance.org\/nl\/soorten-amyloidose\/attrv-amyloidose\/\">ATTRv-amylo\u00efdose \u2192<\/a><\/td><\/tr><tr><td>AA<\/td><td>Serum-amylo\u00efd A (SAA)<\/td><td>Nieren, lever, milt<\/td><td>Behandeling van de onderliggende ontstekingsziekte; anti-IL-1-middelen<\/td><td><a class=\"aa-compare__link\" href=\"https:\/\/www.amyloidosisalliance.org\/nl\/soorten-amyloidose\/aa-amyloidose\/\">AA-amylo\u00efdose \u2192<\/a><\/td><\/tr><tr><td>Zeldzamere erfelijke vormen<\/td><td>ApoA-I, gelsoline, lysozym, fibrinogeen\u2026<\/td><td>Afhankelijk van de soort (nieren, zenuwen, lever)<\/td><td>Ondersteunende behandeling; orgaantransplantatie in bepaalde gevallen<\/td><td><a class=\"aa-compare__link\" href=\"https:\/\/www.amyloidosisalliance.org\/nl\/soorten-amyloidose\/zeldzame-erfelijke-amyloidosen\/\">Zeldzame erfelijke amylo\u00efdose \u2192<\/a><\/td><\/tr><\/tbody><\/table><\/figure>\n<\/div>\n<\/section>\n\n<section class=\"wp-block-group aa-next aa-next--split is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-inner is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-next__head is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"aa-section-num wp-block-paragraph\">Verder lezen<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Lees verder<\/h2>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-next__grid is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-next-card is-layout-flow wp-block-group-is-layout-flow\">\n<h3 class=\"wp-block-heading\"><a href=\"https:\/\/www.amyloidosisalliance.org\/nl\/soorten-amyloidose\/al-amyloidose\/\">AL-amylo\u00efdose<\/a><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">De meest voorkomende systemische vorm in westerse landen, veroorzaakt door verkeerd gevouwen lichte ketens van immunoglobulinen.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-next-card is-layout-flow wp-block-group-is-layout-flow\">\n<h3 class=\"wp-block-heading\"><a href=\"https:\/\/www.amyloidosisalliance.org\/nl\/soorten-amyloidose\/attr-amyloidose\/\">ATTR-amylo\u00efdose<\/a><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">De wild-type en de erfelijke vorm van transthyretine-amylo\u00efdose, en wat ze van elkaar onderscheidt.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-next-card is-layout-flow wp-block-group-is-layout-flow\">\n<h3 class=\"wp-block-heading\"><a href=\"https:\/\/www.amyloidosisalliance.org\/nl\/soorten-amyloidose\/zeldzame-erfelijke-amyloidosen\/\">Zeldzame erfelijke amylo\u00efdosen<\/a><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">De zeldzamere erfelijke vormen, de betrokken eiwitten en de organen die ze meestal aantasten.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n","protected":false},"excerpt":{"rendered":"<p>Home\u203aAmylo\u00efdose\u203aSoorten amylo\u00efdose Amylo\u00efdose Soorten amylo\u00efdose Amylo\u00efdose is niet \u00e9\u00e9n ziekte, maar een familie van afzonderlijke aandoeningen, elk bepaald door het soort eiwit dat verkeerd vouwt en door de organen die het aantast. Inzicht in elke soort is de eerste stap naar een nauwkeurige diagnose en een gerichte behandeling. 01 De diversiteit 02 AL-amylo\u00efdose 03 ATTR-amylo\u00efdose [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-3695","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Soorten amylo\u00efdose: AL, AA, ATTR en zeldzame vormen<\/title>\n<meta name=\"description\" content=\"Amylo\u00efdose is niet \u00e9\u00e9n ziekte, maar een familie van ziekten. 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