{"id":2823,"date":"2026-07-07T14:57:12","date_gmt":"2026-07-07T12:57:12","guid":{"rendered":"https:\/\/www.amyloidosisalliance.org\/la-malattia\/"},"modified":"2026-11-02T11:48:51","modified_gmt":"2026-11-02T10:48:51","slug":"la-malattia","status":"publish","type":"page","link":"https:\/\/www.amyloidosisalliance.org\/it\/la-malattia\/","title":{"rendered":"La malattia"},"content":{"rendered":"\n<nav aria-label=\"Breadcrumb\" class=\"wp-block-group aa-breadcrumb is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"aa-inner\"><a href=\"\/\">Home<\/a><span class=\"aa-breadcrumb__sep\">\u203a<\/span><span class=\"aa-breadcrumb__label\">Amiloidosi<\/span><span class=\"aa-breadcrumb__sep\">\u203a<\/span><span class=\"aa-breadcrumb__current\">La malattia<\/span><\/div>\n<\/nav>\n\n<section class=\"wp-block-group aa-page-hero is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-inner is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-page-hero__grid is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"aa-overline wp-block-paragraph\">Sull\u2019amiloidosi<\/p>\n\n\n\n<h1 class=\"wp-block-heading\">La malattia<\/h1>\n\n\n\n<p class=\"aa-lead wp-block-paragraph\">Una guida approfondita su che cos\u2019\u00e8 l\u2019amiloidosi, come si forma, quali organi colpisce e come si cura, scritta per pazienti, famiglie e professionisti sanitari.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-page-hero__photo is-layout-flow wp-block-group-is-layout-flow\">\n<figure class=\"aa-protein aa-protein--hero\" role=\"img\" aria-label=\"Illustrazione: una proteina correttamente ripiegata assume un ripiegamento errato e si impila in fibrille amiloidi\">\n\t\t\t\t\t<svg viewbox=\"0 0 480 360\" aria-hidden=\"true\" focusable=\"false\">\n\t\t\t\t\t\t<defs>\n\t\t\t\t\t\t\t\t<lineargradient id=\"aa-prot-core\" x1=\"0\" y1=\"0\" x2=\"1\" y2=\"1\">\n\t\t\t\t\t\t\t\t\t<stop offset=\"0%\" stop-color=\"#167a82\"><\/stop>\n\t\t\t\t\t\t\t\t\t<stop offset=\"100%\" stop-color=\"#00666d\"><\/stop>\n\t\t\t\t\t\t\t\t<\/lineargradient>\n\t\t\t\t\t\t\t\t<lineargradient id=\"aa-prot-fib\" x1=\"0\" y1=\"0\" x2=\"1\" y2=\"0\">\n\t\t\t\t\t\t\t\t\t<stop offset=\"0%\" stop-color=\"#f6a955\"><\/stop>\n\t\t\t\t\t\t\t\t\t<stop offset=\"100%\" stop-color=\"#f39325\"><\/stop>\n\t\t\t\t\t\t\t\t<\/lineargradient>\n\t\t\t\t\t\t<\/defs>\n\n\t\t\t\t\t\t<!-- Prot\u00e9ine correctement repli\u00e9e : h\u00e9lice compacte -->\n\t\t\t\t\t\t<g transform=\"translate(96 130)\">\n\t\t\t\t\t\t\t\t<circle r=\"62\" fill=\"#eaf3f3\"><\/circle>\n\t\t\t\t\t\t\t\t<path d=\"M-34 26 C-46 2 -26 -14 -6 -8 C14 -2 30 -16 22 -34\" fill=\"none\" stroke=\"url(#aa-prot-core)\" stroke-width=\"9\" stroke-linecap=\"round\"><\/path>\n\t\t\t\t\t\t\t\t<path d=\"M-26 40 C-4 44 18 30 26 10\" fill=\"none\" stroke=\"url(#aa-prot-core)\" stroke-width=\"9\" stroke-linecap=\"round\" opacity=\"0.55\"><\/path>\n\t\t\t\t\t\t\t\t<circle cx=\"22\" cy=\"-34\" r=\"7\" fill=\"#00666d\"><\/circle>\n\t\t\t\t\t\t\t\t<circle cx=\"-34\" cy=\"26\" r=\"7\" fill=\"#00666d\"><\/circle>\n\t\t\t\t\t\t<\/g>\n\n\t\t\t\t\t\t<!-- Transition -->\n\t\t\t\t\t\t<g stroke=\"#c9d2d6\" stroke-width=\"2\" stroke-linecap=\"round\">\n\t\t\t\t\t\t\t\t<line x1=\"176\" y1=\"130\" x2=\"212\" y2=\"130\" stroke-dasharray=\"2 8\"><\/line>\n\t\t\t\t\t\t\t\t<path d=\"M206 122 L216 130 L206 138\" fill=\"none\"><\/path>\n\t\t\t\t\t\t<\/g>\n\n\t\t\t\t\t\t<!-- Prot\u00e9ine mal repli\u00e9e : feuillets b\u00eata empil\u00e9s -->\n\t\t\t\t\t\t<g transform=\"translate(300 130)\">\n\t\t\t\t\t\t\t\t<g fill=\"none\" stroke=\"url(#aa-prot-fib)\" stroke-width=\"8\" stroke-linecap=\"round\">\n\t\t\t\t\t\t\t\t\t<path d=\"M-56 -34 L-20 -34 L-20 -14 L16 -14 L16 -34 L52 -34\"><\/path>\n\t\t\t\t\t\t\t\t\t<path d=\"M-56 -6 L-20 -6 L-20 14 L16 14 L16 -6 L52 -6\"><\/path>\n\t\t\t\t\t\t\t\t\t<path d=\"M-56 22 L-20 22 L-20 42 L16 42 L16 22 L52 22\"><\/path>\n\t\t\t\t\t\t\t\t<\/g>\n\t\t\t\t\t\t<\/g>\n\n\t\t\t\t\t\t<!-- Fibrille amylo\u00efde : les feuillets s'assemblent en filament -->\n\t\t\t\t\t\t<g transform=\"translate(240 268)\" fill=\"none\" stroke-linecap=\"round\">\n\t\t\t\t\t\t\t\t<path d=\"M-190 0 C-150 -22 -110 22 -70 0 C-30 -22 10 22 50 0 C90 -22 130 22 170 0\" stroke=\"url(#aa-prot-fib)\" stroke-width=\"7\"><\/path>\n\t\t\t\t\t\t\t\t<path d=\"M-190 14 C-150 -8 -110 36 -70 14 C-30 -8 10 36 50 14 C90 -8 130 36 170 14\" stroke=\"url(#aa-prot-fib)\" stroke-width=\"7\" opacity=\"0.45\"><\/path>\n\t\t\t\t\t\t<\/g>\n\n\t\t\t\t\t\t<text x=\"96\" y=\"222\" text-anchor=\"middle\" fill=\"#5a6a73\" font-family=\"'JetBrains Mono', ui-monospace, monospace\" font-size=\"12\" letter-spacing=\"1.4\">RIPIEGATA<\/text>\n\t\t\t\t\t\t<text x=\"300\" y=\"222\" text-anchor=\"middle\" fill=\"#5a6a73\" font-family=\"'JetBrains Mono', ui-monospace, monospace\" font-size=\"12\" letter-spacing=\"1.4\">MAL RIPIEGATA<\/text>\n\t\t\t\t\t\t<text x=\"240\" y=\"320\" text-anchor=\"middle\" fill=\"#5a6a73\" font-family=\"'JetBrains Mono', ui-monospace, monospace\" font-size=\"12\" letter-spacing=\"1.4\">FIBRILLA AMILOIDE<\/text>\n\t\t\t\t\t<\/svg>\n\t\t\t\t<\/figure>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n\n<nav aria-label=\"Section navigation\" class=\"wp-block-group aa-anchorband is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-inner is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-columns aa-anchor-cols is-layout-flex wp-container-core-columns-is-layout-b2e659ba wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column aa-anchor-item is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"num wp-block-paragraph\">01<\/p>\n\n\n\n<p class=\"lbl wp-block-paragraph\"><a href=\"#what\">Di che cosa si tratta?<\/a><\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column aa-anchor-item is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"num wp-block-paragraph\">02<\/p>\n\n\n\n<p class=\"lbl wp-block-paragraph\"><a href=\"#deposits\">Depositi<\/a><\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column aa-anchor-item is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"num wp-block-paragraph\">03<\/p>\n\n\n\n<p class=\"lbl wp-block-paragraph\"><a href=\"#forms\">Come si forma<\/a><\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column aa-anchor-item is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"num wp-block-paragraph\">04<\/p>\n\n\n\n<p class=\"lbl wp-block-paragraph\"><a href=\"#protein\">Dalla proteina all\u2019organo<\/a><\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column aa-anchor-item is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"num wp-block-paragraph\">05<\/p>\n\n\n\n<p class=\"lbl wp-block-paragraph\"><a href=\"#symptoms\">Sintomi<\/a><\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column aa-anchor-item is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"num wp-block-paragraph\">06<\/p>\n\n\n\n<p class=\"lbl wp-block-paragraph\"><a href=\"#diversity\">Diversit\u00e0<\/a><\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column aa-anchor-item is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"num wp-block-paragraph\">07<\/p>\n\n\n\n<p class=\"lbl wp-block-paragraph\"><a href=\"#treating\">Trattamenti<\/a><\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column aa-anchor-item is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"num wp-block-paragraph\">08<\/p>\n\n\n\n<p class=\"lbl wp-block-paragraph\"><a href=\"#living\">Conviverci<\/a><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/nav>\n\n<section id=\"what\" class=\"wp-block-group aa-section aa-section--white aa-what is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-inner is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"aa-section-num wp-block-paragraph\">01<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Che cos\u2019\u00e8 l\u2019amiloidosi?<\/h2>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-what-cols is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-what-col is-layout-flow wp-block-group-is-layout-flow\">\n<h4 class=\"wp-block-heading\">Una malattia del ripiegamento delle proteine<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">L\u2019amiloidosi \u00e8 un gruppo di malattie in cui alcune proteine si ripiegano in modo errato e si accumulano nei tessuti e negli organi. Queste proteine mal ripiegate formano fibrille insolubili, chiamate fibrille amiloidi, che alterano la struttura e il normale funzionamento degli organi. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Il processo inizia a livello molecolare: una proteina normalmente innocua diventa instabile, cambia forma e comincia ad aggregarsi in strutture fibrose attorcigliate che l\u2019organismo non riesce a eliminare facilmente.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-what-col is-layout-flow wp-block-group-is-layout-flow\">\n<h4 class=\"wp-block-heading\">Depositi negli organi<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Una volta formate, le fibrille amiloidi si depositano nella matrice extracellulare degli organi, riempiendo di fatto gli spazi tra le cellule. Man mano che i depositi si accumulano, irrigidiscono progressivamente i tessuti e compromettono le funzioni elettriche, meccaniche o di filtrazione dell\u2019organo colpito.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Il cuore diventa rigido e non riesce pi\u00f9 a riempirsi normalmente; i reni perdono la capacit\u00e0 di trattenere le proteine; i nervi non trasmettono pi\u00f9 i segnali. Il numero di organi colpiti e la gravit\u00e0 del danno variano molto a seconda del sottotipo di amiloidosi.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n\n<section id=\"deposits\" class=\"wp-block-group aa-section aa-section--cream aa-deposits is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-inner is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-deposits__photo is-layout-flow wp-block-group-is-layout-flow\">\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"683\" src=\"https:\/\/www.amyloidosisalliance.org\/wp-content\/uploads\/2026\/09\/laboratory-microscope-1024x683.jpg\" alt=\"Microscopio da laboratorio\" class=\"wp-image-708\" srcset=\"https:\/\/www.amyloidosisalliance.org\/wp-content\/uploads\/2026\/09\/laboratory-microscope-1024x683.jpg 1024w, https:\/\/www.amyloidosisalliance.org\/wp-content\/uploads\/2026\/09\/laboratory-microscope-300x200.jpg 300w, https:\/\/www.amyloidosisalliance.org\/wp-content\/uploads\/2026\/09\/laboratory-microscope-768x512.jpg 768w, https:\/\/www.amyloidosisalliance.org\/wp-content\/uploads\/2026\/09\/laboratory-microscope-1536x1024.jpg 1536w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-group is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"aa-section-num wp-block-paragraph\">02<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Capire i depositi amiloidi<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">A differenza della maggior parte delle proteine, che vengono eliminate dai tessuti quando si danneggiano, le fibrille amiloidi resistono fortemente ai normali sistemi di degradazione delle proteine dell\u2019organismo. Si accumulano progressivamente e i loro effetti si sommano nel tempo.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">La diagnosi richiede di solito una biopsia con colorazione rosso Congo: alla luce polarizzata i depositi amiloidi mostrano una caratteristica birifrangenza verde mela, uno dei reperti pi\u00f9 specifici dell\u2019anatomia patologica.<\/p>\n\n\n\n<div class=\"wp-block-group aa-key-idea is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"aa-key-idea__label wp-block-paragraph\">Punto clinico chiave<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Le fibrille amiloidi possono depositarsi praticamente in qualsiasi organo o tessuto. La loro distribuzione (quali organi sono pi\u00f9 colpiti e in che misura) dipende strettamente dal sottotipo e determina sia il quadro clinico sia la strategia di trattamento.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n\n<section id=\"forms\" class=\"wp-block-group aa-section aa-section--white aa-forms is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-inner is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-centered-head is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"aa-section-num wp-block-paragraph\">03<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Come si forma la sostanza amiloide<\/h2>\n\n\n\n<div class=\"aa-divider-dot\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">Una panoramica, passo dopo passo, del meccanismo molecolare che porta dalla normale produzione di una proteina al danno dei tessuti.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-proc-grid is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-proc-step is-layout-flow wp-block-group-is-layout-flow\">\n<span class=\"aa-proc-step__icon\"><svg aria-hidden=\"true\" focusable=\"false\" width=\"24\" height=\"24\" viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><path d=\"M12 3l2.5 6.5L21 12l-6.5 2.5L12 21l-2.5-6.5L3 12l6.5-2.5z\"><\/path><\/svg><\/span>\n\n\n\n<p class=\"aa-proc-step__num wp-block-paragraph\">Fase 01<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Una proteina normale<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">L\u2019organismo produce una normale proteina precursore (transtiretina, catene leggere, SAA o altre) nell\u2019ambito di processi biologici ordinari.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-proc-step is-layout-flow wp-block-group-is-layout-flow\">\n<span class=\"aa-proc-step__icon\"><svg aria-hidden=\"true\" focusable=\"false\" width=\"24\" height=\"24\" viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><polyline points=\"16 3 21 3 21 8\"><\/polyline><line x1=\"4\" y1=\"20\" x2=\"21\" y2=\"3\"><\/line><polyline points=\"21 16 21 21 16 21\"><\/polyline><line x1=\"15\" y1=\"15\" x2=\"21\" y2=\"21\"><\/line><line x1=\"4\" y1=\"4\" x2=\"9\" y2=\"9\"><\/line><\/svg><\/span>\n\n\n\n<p class=\"aa-proc-step__num wp-block-paragraph\">Fase 02<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Il ripiegamento errato<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">A causa di una mutazione genetica, di una sovrapproduzione, dell\u2019invecchiamento o di un\u2019infiammazione cronica, la proteina diventa strutturalmente instabile e si ripiega in modo errato.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-proc-step is-layout-flow wp-block-group-is-layout-flow\">\n<span class=\"aa-proc-step__icon\"><svg aria-hidden=\"true\" focusable=\"false\" width=\"24\" height=\"24\" viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><path d=\"M10 13a5 5 0 0 0 7.54.54l3-3a5 5 0 0 0-7.07-7.07l-1.72 1.71\"><\/path><path d=\"M14 11a5 5 0 0 0-7.54-.54l-3 3a5 5 0 0 0 7.07 7.07l1.71-1.71\"><\/path><\/svg><\/span>\n\n\n\n<p class=\"aa-proc-step__num wp-block-paragraph\">Fase 03<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Le fibrille amiloidi<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Le proteine mal ripiegate si aggregano e si autoassemblano in strutture fibrillari insolubili a foglietti \u03b2, che resistono alla degradazione enzimatica.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-proc-step is-layout-flow wp-block-group-is-layout-flow\">\n<span class=\"aa-proc-step__icon\"><svg aria-hidden=\"true\" focusable=\"false\" width=\"24\" height=\"24\" viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><path d=\"M10.29 3.86L1.82 18a2 2 0 0 0 1.71 3h16.94a2 2 0 0 0 1.71-3L13.71 3.86a2 2 0 0 0-3.42 0z\"><\/path><line x1=\"12\" y1=\"9\" x2=\"12\" y2=\"13\"><\/line><line x1=\"12\" y1=\"17\" x2=\"12.01\" y2=\"17\"><\/line><\/svg><\/span>\n\n\n\n<p class=\"aa-proc-step__num wp-block-paragraph\">Fase 04<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Il danno agli organi<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Le fibrille si depositano nella matrice extracellulare degli organi, spostano il tessuto normale, ne irrigidiscono la struttura e ne compromettono progressivamente il funzionamento.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n\n<section id=\"protein\" class=\"wp-block-group aa-section aa-section--cream aa-protein is-layout-flow wp-block-group-is-layout-flow\" style=\"padding-top:var(--wp--preset--spacing--70);padding-bottom:var(--wp--preset--spacing--70)\">\n<div class=\"wp-block-group aa-inner is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"aa-section-num wp-block-paragraph\">04<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Dalla proteina al danno d\u2019organo<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Il percorso da una proteina mal ripiegata a una diagnosi che cambia la vita pu\u00f2 durare anni, perfino decenni. I sintomi sono insidiosi e poco specifici, spesso attribuiti all\u2019invecchiamento o a malattie pi\u00f9 comuni, con un ritardo diagnostico che in media supera i quattro anni dai primi sintomi.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Comprendere i meccanismi del danno d\u2019organo (cardiomiopatia, sindrome nefrosica, neuropatia periferica) \u00e8 fondamentale per riconoscere precocemente la malattia e iniziare un trattamento prima che le lesioni diventino irreversibili.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-protein__photo is-layout-flow wp-block-group-is-layout-flow\">\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" src=\"\/wp-content\/themes\/amyloidosis-alliance\/assets\/images\/tissue-amyloid.svg\" alt=\"Tessuto infiltrato dalla sostanza amiloide: a sinistra, in un tessuto sano, le cellule sono vicine le une alle altre; verso destra si retraggono e i depositi amiloidi riempiono lo spazio che si allarga tra di esse\"\/><\/figure>\n<\/div>\n<\/div>\n<\/section>\n\n<section id=\"symptoms\" class=\"wp-block-group aa-section aa-section--cream aa-symptoms is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-inner is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-centered-head is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"aa-section-num wp-block-paragraph\">05<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Sintomi e organi colpiti<\/h2>\n\n\n\n<div class=\"aa-divider-dot\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">Una semplice mappa del corpo per aiutare pazienti e professionisti sanitari a collegare i segnali d\u2019allarme agli organi colpiti dall\u2019amiloidosi. Passate il cursore su ciascun punto per maggiori dettagli.<\/p>\n<\/div>\n\n\n\n<div class=\"aa-body-card\">\n\t\t\t<div class=\"aa-organ-side\">\n\t\t\t\t<div class=\"aa-organ-label\"><span class=\"aa-organ-label__name\">Occhio e vista<\/span><h4>Depositi nel vitreo<\/h4><p>Corpi mobili (mosche volanti), disturbi visivi transitori e opacit\u00e0 del vitreo dovuti all\u2019accumulo di proteina amiloide nell\u2019occhio.<\/p><\/div>\n\t\t\t\t<div class=\"aa-organ-label\"><span class=\"aa-organ-label__name\">Reni<\/span><h4>Proteinuria ed edemi<\/h4><p>Passaggio di proteine nelle urine, riduzione della funzione renale e gonfiore progressivo degli arti inferiori dovuto alla sindrome nefrosica.<\/p><\/div>\n\t\t\t\t<div class=\"aa-organ-label\"><span class=\"aa-organ-label__name\">Fegato e milza<\/span><h4>Organomegalia<\/h4><p>Ingrossamento del fegato o della milza, che provoca senso di pienezza, saziet\u00e0 precoce e alterazioni degli esami di funzionalit\u00e0 epatica: un reperto precoce frequente nell\u2019amiloidosi AL.<\/p><\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"aa-body-center\">\n\t\t\t\t<div class=\"aa-body-svg-wrap\">\n\t\t\t\t\t<svg class=\"aa-body-svg\" viewbox=\"0 0 200 480\" aria-hidden=\"true\">\n\t\t\t\t\t\t<circle cx=\"100\" cy=\"46\" r=\"34\" fill=\"none\" stroke=\"#00666d\" stroke-width=\"2\" opacity=\"0.4\"><\/circle>\n\t\t\t\t\t\t<rect x=\"90\" y=\"79\" width=\"20\" height=\"18\" rx=\"4\" fill=\"none\" stroke=\"#00666d\" stroke-width=\"1.5\" opacity=\"0.35\"><\/rect>\n\t\t\t\t\t\t<path d=\"M80 97 Q55 102 42 124\" fill=\"none\" stroke=\"#00666d\" stroke-width=\"2\" opacity=\"0.4\" stroke-linecap=\"round\"><\/path>\n\t\t\t\t\t\t<path d=\"M120 97 Q145 102 158 124\" fill=\"none\" stroke=\"#00666d\" stroke-width=\"2\" opacity=\"0.4\" stroke-linecap=\"round\"><\/path>\n\t\t\t\t\t\t<path d=\"M42 124 L38 260 Q68 272 100 274 Q132 272 162 260 L158 124\" fill=\"none\" stroke=\"#00666d\" stroke-width=\"2\" opacity=\"0.4\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><\/path>\n\t\t\t\t\t\t<path d=\"M42 124 Q30 170 24 224\" fill=\"none\" stroke=\"#00666d\" stroke-width=\"2\" opacity=\"0.4\" stroke-linecap=\"round\"><\/path>\n\t\t\t\t\t\t<path d=\"M158 124 Q170 170 176 224\" fill=\"none\" stroke=\"#00666d\" stroke-width=\"2\" opacity=\"0.4\" stroke-linecap=\"round\"><\/path>\n\t\t\t\t\t\t<ellipse cx=\"21\" cy=\"234\" rx=\"10\" ry=\"14\" fill=\"none\" stroke=\"#00666d\" stroke-width=\"1.5\" opacity=\"0.35\"><\/ellipse>\n\t\t\t\t\t\t<ellipse cx=\"179\" cy=\"234\" rx=\"10\" ry=\"14\" fill=\"none\" stroke=\"#00666d\" stroke-width=\"1.5\" opacity=\"0.35\"><\/ellipse>\n\t\t\t\t\t\t<path d=\"M38 260 Q68 278 100 280 Q132 278 162 260\" fill=\"none\" stroke=\"#00666d\" stroke-width=\"2\" opacity=\"0.4\" stroke-linecap=\"round\"><\/path>\n\t\t\t\t\t\t<path d=\"M70 280 Q60 340 58 420\" fill=\"none\" stroke=\"#00666d\" stroke-width=\"2\" opacity=\"0.4\" stroke-linecap=\"round\"><\/path>\n\t\t\t\t\t\t<path d=\"M130 280 Q140 340 142 420\" fill=\"none\" stroke=\"#00666d\" stroke-width=\"2\" opacity=\"0.4\" stroke-linecap=\"round\"><\/path>\n\t\t\t\t\t\t<ellipse cx=\"56\" cy=\"430\" rx=\"14\" ry=\"8\" fill=\"none\" stroke=\"#00666d\" stroke-width=\"1.5\" opacity=\"0.35\"><\/ellipse>\n\t\t\t\t\t\t<ellipse cx=\"144\" cy=\"430\" rx=\"14\" ry=\"8\" fill=\"none\" stroke=\"#00666d\" stroke-width=\"1.5\" opacity=\"0.35\"><\/ellipse>\n\t\t\t\t\t\t<path d=\"M87 165 Q87 155 95 155 Q100 155 100 162 Q100 155 105 155 Q113 155 113 165 Q113 174 100 184 Q87 174 87 165 Z\" fill=\"none\" stroke=\"#f39325\" stroke-width=\"1.5\" opacity=\"0.7\"><\/path>\n\t\t\t\t\t\t<ellipse cx=\"84\" cy=\"215\" rx=\"9\" ry=\"13\" fill=\"none\" stroke=\"#f39325\" stroke-width=\"1.2\" opacity=\"0.6\"><\/ellipse>\n\t\t\t\t\t\t<ellipse cx=\"116\" cy=\"215\" rx=\"9\" ry=\"13\" fill=\"none\" stroke=\"#f39325\" stroke-width=\"1.2\" opacity=\"0.6\"><\/ellipse>\n\t\t\t\t\t\t<line x1=\"100\" y1=\"97\" x2=\"100\" y2=\"270\" stroke=\"#00666d\" stroke-width=\"1\" stroke-dasharray=\"4 4\" opacity=\"0.2\"><\/line>\n\t\t\t\t\t<\/svg>\n\t\t\t\t\t<div class=\"aa-hotspot\" style=\"top:5%;left:58%;transform:translate(-50%,-50%)\"><div class=\"aa-hotspot__dot\"><\/div><div class=\"aa-hotspot-tip aa-tip-left\"><div class=\"aa-hotspot-tip__title\">Occhio e vista<\/div><p>Le fibrille amiloidi si depositano nell\u2019umor vitreo, causando le caratteristiche \u00abmosche volanti\u00bb e, col tempo, un calo della vista. L\u2019amiloidosi vitreale \u00e8 un segno distintivo dell\u2019amiloidosi ATTR ereditaria.<\/p><\/div><\/div>\n\t\t\t\t\t<div class=\"aa-hotspot\" style=\"top:36%;left:43%;transform:translate(-50%,-50%)\"><div class=\"aa-hotspot__dot\"><\/div><div class=\"aa-hotspot-tip aa-tip-right\"><div class=\"aa-hotspot-tip__title\">Cuore<\/div><p>L\u2019amiloidosi cardiaca provoca un ispessimento delle pareti ventricolari, una cardiomiopatia restrittiva e disturbi della conduzione, che si manifestano con affanno, edemi e aritmie.<\/p><\/div><\/div>\n\t\t\t\t\t<div class=\"aa-hotspot\" style=\"top:41%;left:66%;transform:translate(-50%,-50%)\"><div class=\"aa-hotspot__dot\"><\/div><div class=\"aa-hotspot-tip aa-tip-right\"><div class=\"aa-hotspot-tip__title\">Fegato e milza<\/div><p>La sostanza amiloide infiltra il parenchima del fegato e della milza, causando epatomegalia, aumento della fosfatasi alcalina e saziet\u00e0 precoce. Il coinvolgimento del fegato \u00e8 pi\u00f9 frequente nell\u2019amiloidosi AL.<\/p><\/div><\/div>\n\t\t\t\t\t<div class=\"aa-hotspot\" style=\"top:47%;left:50%;transform:translate(-50%,-50%)\"><div class=\"aa-hotspot__dot\"><\/div><div class=\"aa-hotspot-tip aa-tip-right\"><div class=\"aa-hotspot-tip__title\">Reni<\/div><p>I depositi amiloidi nei glomeruli renali alterano la barriera di filtrazione, causando una proteinuria importante, una sindrome nefrosica e un\u2019insufficienza renale progressiva, soprattutto nelle amiloidosi AL e AA.<\/p><\/div><\/div>\n\t\t\t\t\t<div class=\"aa-hotspot\" style=\"top:50%;left:12%;transform:translate(-50%,-50%)\"><div class=\"aa-hotspot__dot\"><\/div><div class=\"aa-hotspot-tip aa-tip-right\"><div class=\"aa-hotspot-tip__title\">Nervi periferici<\/div><p>Le fibrille amiloidi comprimono e infiltrano i nervi periferici, causando una neuropatia sensitivo-motoria progressiva: intorpidimento, formicolio e debolezza che iniziano all\u2019estremit\u00e0 delle mani e dei piedi.<\/p><\/div><\/div>\n\t\t\t\t\t<div class=\"aa-hotspot\" style=\"top:78%;left:50%;transform:translate(-50%,-50%)\"><div class=\"aa-hotspot__dot\"><\/div><div class=\"aa-hotspot-tip aa-tip-bottom\"><div class=\"aa-hotspot-tip__title\">Arti inferiori<\/div><p>Gli edemi delle caviglie e degli arti inferiori sono dovuti a uno scompenso cardiaco, a una sindrome nefrosica o a entrambi. Edemi bilaterali improntabili che peggiorano nel corso della giornata sono un segno chiave che deve indurre ad accertamenti per l\u2019amiloidosi.<\/p><\/div><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<p class=\"aa-body-hint\">Passate il cursore sui punti per maggiori dettagli<\/p>\n\t\t\t<\/div>\n\t\t\t<div class=\"aa-organ-side\">\n\t\t\t\t<div class=\"aa-organ-label is-right\"><span class=\"aa-organ-label__name\">Cuore<\/span><h4>Cardiomiopatia<\/h4><p>Affanno, gonfiore delle caviglie e aritmie dovuti a una cardiomiopatia restrittiva, causata dall\u2019infiltrazione amiloide delle pareti ventricolari.<\/p><\/div>\n\t\t\t\t<div class=\"aa-organ-label is-right\"><span class=\"aa-organ-label__name\">Nervi periferici<\/span><h4>Neuropatia sensitivo-motoria<\/h4><p>Formicolio, intorpidimento e perdita di sensibilit\u00e0 che iniziano negli arti inferiori e risalgono, spesso scambiati per una neuropatia diabetica o idiopatica.<\/p><\/div>\n\t\t\t\t<div class=\"aa-organ-label is-right\"><span class=\"aa-organ-label__name\">Arti inferiori<\/span><h4>Edemi bilaterali<\/h4><p>Gonfiore progressivo di entrambe le caviglie, spesso sproporzionato rispetto ai reperti cardiaci o renali, che riflette un coinvolgimento multisistemico e una ritenzione di liquidi.<\/p><\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n<\/div>\n<\/section>\n\n<section id=\"diversity\" class=\"wp-block-group aa-section aa-section--white aa-diversity is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-inner is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-diversity__left is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"aa-section-num wp-block-paragraph\">06<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">La diversit\u00e0 dell\u2019amiloidosi<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Sono note pi\u00f9 di 40 proteine precursori umane in grado di formare depositi amiloidi, ciascuna delle quali d\u00e0 origine a un proprio sottotipo, con quadro clinico, organi bersaglio, contesto genetico e percorso di trattamento distinti.<\/p>\n\n\n\n<div class=\"wp-block-group aa-diversity__photo is-layout-flow wp-block-group-is-layout-flow\">\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"1080\" height=\"1350\" src=\"https:\/\/www.amyloidosisalliance.org\/wp-content\/uploads\/2026\/09\/Design-sans-titre.zip-1.jpg\" alt=\"\" class=\"wp-image-1188\" srcset=\"https:\/\/www.amyloidosisalliance.org\/wp-content\/uploads\/2026\/09\/Design-sans-titre.zip-1.jpg 1080w, https:\/\/www.amyloidosisalliance.org\/wp-content\/uploads\/2026\/09\/Design-sans-titre.zip-1-240x300.jpg 240w, https:\/\/www.amyloidosisalliance.org\/wp-content\/uploads\/2026\/09\/Design-sans-titre.zip-1-819x1024.jpg 819w, https:\/\/www.amyloidosisalliance.org\/wp-content\/uploads\/2026\/09\/Design-sans-titre.zip-1-768x960.jpg 768w\" sizes=\"auto, (max-width: 1080px) 100vw, 1080px\" \/><\/figure>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-acc is-layout-flow wp-block-group-is-layout-flow\">\n<details class=\"wp-block-details is-layout-flow wp-block-details-is-layout-flow\" open><summary>La proteina amiloide<\/summary>\n<p class=\"wp-block-paragraph\">La proteina precursore definisce il sottotipo di amiloidosi. Le pi\u00f9 frequenti sono: le catene leggere delle immunoglobuline (AL), la transtiretina (ATTR), la proteina sierica amiloide A (AA) e una serie di varianti ereditarie, tra cui l\u2019apolipoproteina A-I, la gelsolina, il lisozima e la catena alfa del fibrinogeno.<\/p>\n\n\n\n<ul class=\"wp-block-list aa-acc__tags\">\n<li>AL \u00b7 Catene leggere<\/li>\n\n\n\n<li>ATTR \u00b7 Transtiretina<\/li>\n\n\n\n<li>AA \u00b7 SAA<\/li>\n<\/ul>\n<\/details>\n\n\n\n<details class=\"wp-block-details is-layout-flow wp-block-details-is-layout-flow\"><summary>Organi colpiti<\/summary>\n<p class=\"wp-block-paragraph\">Il tropismo d\u2019organo dipende dal tipo di proteina amiloide. L\u2019amiloidosi AL colpisce in genere cuore, reni, fegato, nervi e tessuti molli. L\u2019amiloidosi ATTR ha una particolare affinit\u00e0 per il cuore e il sistema nervoso periferico. L\u2019amiloidosi AA colpisce quasi esclusivamente i reni. I sottotipi ereditari variano in base alla mutazione genetica.<\/p>\n\n\n\n<ul class=\"wp-block-list aa-acc__tags\">\n<li>Cuore<\/li>\n\n\n\n<li>Reni<\/li>\n\n\n\n<li>Fegato<\/li>\n\n\n\n<li>Nervi<\/li>\n\n\n\n<li>Tratto gastrointestinale<\/li>\n<\/ul>\n<\/details>\n\n\n\n<details class=\"wp-block-details is-layout-flow wp-block-details-is-layout-flow\"><summary>I diversi tipi<\/summary>\n<p class=\"wp-block-paragraph\">L\u2019amiloidosi pu\u00f2 essere sistemica (coinvolgimento esteso degli organi) o localizzata (limitata a un solo tessuto, come le vie respiratorie, la vescica o la pelle). Le forme sistemiche si dividono a loro volta in acquisite (AL, AA) ed ereditarie (ATTRv, ApoA-I, gelsolina\u2026), ciascuna con una propria modalit\u00e0 di trasmissione e una propria strategia di gestione.<\/p>\n\n\n\n<ul class=\"wp-block-list aa-acc__tags\">\n<li>Sistemica<\/li>\n\n\n\n<li>Localizzata<\/li>\n\n\n\n<li>Ereditaria<\/li>\n\n\n\n<li>Acquisita<\/li>\n<\/ul>\n<\/details>\n<\/div>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\" style=\"margin-top:36px\">\n<div class=\"wp-block-button aa-btn aa-btn--teal\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.amyloidosisalliance.org\/it\/tipi-di-amiloidosi\/\">Scoprite tutti i tipi \u2192<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n\n<section id=\"treating\" class=\"wp-block-group aa-section aa-section--cream aa-treating is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-inner is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-centered-head is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"aa-section-num wp-block-paragraph\">07<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Trattare l\u2019amiloidosi<\/h2>\n\n\n\n<div class=\"aa-divider-dot\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">Il trattamento dipende dal tipo di amiloidosi. Pu\u00f2 mirare a ridurre la produzione della proteina precursore, a stabilizzare la proteina, a sostenere gli organi colpiti e ad alleviare i sintomi.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-treating-grid is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-treating-card is-layout-flow wp-block-group-is-layout-flow\">\n<span class=\"aa-icon-tile\"><svg aria-hidden=\"true\" focusable=\"false\" width=\"24\" height=\"24\" viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><circle cx=\"12\" cy=\"12\" r=\"10\"><\/circle><circle cx=\"12\" cy=\"12\" r=\"6\"><\/circle><circle cx=\"12\" cy=\"12\" r=\"2\"><\/circle><\/svg><\/span>\n\n\n\n<h3 class=\"wp-block-heading\">Terapie modificanti la malattia<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Terapie rivolte all\u2019origine della sostanza amiloide: chemioterapia per l\u2019amiloidosi AL (soppressione delle plasmacellule), stabilizzatori della TTR e silenziatori genici per l\u2019amiloidosi ATTR, antinfiammatori per l\u2019amiloidosi AA, con l\u2019obiettivo di arrestare la formazione di nuovi depositi.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-treating-card is-layout-flow wp-block-group-is-layout-flow\">\n<span class=\"aa-icon-tile\"><svg aria-hidden=\"true\" focusable=\"false\" width=\"24\" height=\"24\" viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><path d=\"M19 14c1.49-1.46 3-3.21 3-5.5A5.5 5.5 0 0 0 16.5 3c-1.76 0-3 .5-4.5 2-1.5-1.5-2.74-2-4.5-2A5.5 5.5 0 0 0 2 8.5c0 2.29 1.51 4.04 3 5.5l7 7Z\"><\/path><path d=\"M3.22 12H9.5l.5-1 2 4.5 2-7 1.5 3.5h5.27\"><\/path><\/svg><\/span>\n\n\n\n<h3 class=\"wp-block-heading\">Terapie di supporto<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">La gestione delle complicanze specifiche di ciascun organo: diuretici e antiaritmici per l\u2019amiloidosi cardiaca, ACE-inibitori per la protezione dei reni, terapia del dolore e fisioterapia per la neuropatia periferica.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-treating-card is-layout-flow wp-block-group-is-layout-flow\">\n<span class=\"aa-icon-tile\"><svg aria-hidden=\"true\" focusable=\"false\" width=\"24\" height=\"24\" viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><path d=\"M22 11.08V12a10 10 0 1 1-5.93-9.14\"><\/path><polyline points=\"22 4 12 14.01 9 11.01\"><\/polyline><\/svg><\/span>\n\n\n\n<h3 class=\"wp-block-heading\">Il follow-up a lungo termine<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Un monitoraggio regolare con biomarcatori (NT-proBNP, troponina, creatinina), esami di imaging e valutazione della qualit\u00e0 di vita, per seguire la risposta al trattamento, individuare precocemente una ricaduta e adattare la terapia all\u2019evoluzione della malattia.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n\n<section id=\"living\" class=\"wp-block-group aa-section aa-section--white aa-living is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-inner is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-living__photo is-layout-flow wp-block-group-is-layout-flow\">\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"576\" src=\"https:\/\/www.amyloidosisalliance.org\/wp-content\/uploads\/2026\/09\/doctor-talking-with-an-elderly-patient-1024x576.jpg\" alt=\"Un medico parla con una paziente anziana\" class=\"wp-image-712\" srcset=\"https:\/\/www.amyloidosisalliance.org\/wp-content\/uploads\/2026\/09\/doctor-talking-with-an-elderly-patient-1024x576.jpg 1024w, https:\/\/www.amyloidosisalliance.org\/wp-content\/uploads\/2026\/09\/doctor-talking-with-an-elderly-patient-300x169.jpg 300w, https:\/\/www.amyloidosisalliance.org\/wp-content\/uploads\/2026\/09\/doctor-talking-with-an-elderly-patient-768x432.jpg 768w, https:\/\/www.amyloidosisalliance.org\/wp-content\/uploads\/2026\/09\/doctor-talking-with-an-elderly-patient-1536x864.jpg 1536w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-group is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"aa-section-num wp-block-paragraph\">08<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Vivere con una diagnosi rara<\/h2>\n\n\n\n<p class=\"aa-living__intro wp-block-paragraph\">Ricevere una diagnosi di amiloidosi cambia la vita. La rarit\u00e0 della malattia fa s\u00ec che molti pazienti si sentano isolati, incompresi e incerti sul futuro. Prepararsi, creare legami e accedere alle informazioni giuste fanno una profonda differenza.<\/p>\n\n\n\n<div class=\"wp-block-group aa-living-cols is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-living-col is-layout-flow wp-block-group-is-layout-flow\">\n<h4 class=\"wp-block-heading\">Conoscete il vostro tipo<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Il sottotipo di amiloidosi determina la vostra prognosi, il vostro trattamento e il rischio per i vostri familiari. Confermare la proteina esatta coinvolta (con esami del sangue, analisi genetica e tipizzazione della biopsia) \u00e8 il primo passo essenziale.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-living-col is-layout-flow wp-block-group-is-layout-flow\">\n<h4 class=\"wp-block-heading\">Preparate le vostre domande<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Usate il nostro Toolkit per i pazienti per organizzare i colloqui con la vostra \u00e9quipe specialistica: quale trattamento \u00e8 raccomandato, quali sono gli obiettivi, come verr\u00e0 seguita l\u2019evoluzione e quali servizi di supporto sono disponibili vicino a voi.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n\n<section class=\"wp-block-group aa-next aa-next--split is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-inner is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-next__head is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"aa-section-num wp-block-paragraph\">Continua<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Da leggere anche<\/h2>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-next__grid is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-next-card is-layout-flow wp-block-group-is-layout-flow\">\n<h3 class=\"wp-block-heading\"><a href=\"https:\/\/www.amyloidosisalliance.org\/it\/tipi-di-amiloidosi\/\">Tipi di amiloidosi<\/a><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Una guida dettagliata a tutti i sottotipi di amiloidosi (AL, ATTR, AA e forme ereditarie pi\u00f9 rare), con una tabella comparativa.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-next-card is-layout-flow wp-block-group-is-layout-flow\">\n<h3 class=\"wp-block-heading\"><a href=\"#symptoms\">Sintomi e diagnosi<\/a><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Come riconoscere i segnali d\u2019allarme clinici e in che cosa consiste il percorso diagnostico, dal primo sospetto alla tipizzazione confermata.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-next-card is-layout-flow wp-block-group-is-layout-flow\">\n<h3 class=\"wp-block-heading\"><a href=\"#treating\">Trattamenti<\/a><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Il panorama terapeutico attuale, dalla chemioterapia e dagli stabilizzatori della TTR ai silenziatori genici e alle cure di supporto.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n","protected":false},"excerpt":{"rendered":"<p>Home\u203aAmiloidosi\u203aLa malattia Sull\u2019amiloidosi La malattia Una guida approfondita su che cos\u2019\u00e8 l\u2019amiloidosi, come si forma, quali organi colpisce e come si cura, scritta per pazienti, famiglie e professionisti sanitari. RIPIEGATA MAL RIPIEGATA FIBRILLA AMILOIDE 01 Di che cosa si tratta? 02 Depositi 03 Come si forma 04 Dalla proteina all\u2019organo 05 Sintomi 06 Diversit\u00e0 07 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-2823","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Che cos\u2019\u00e8 l\u2019amiloidosi? 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