{"id":1719,"date":"2023-06-28T08:23:00","date_gmt":"2023-06-28T06:23:00","guid":{"rendered":"https:\/\/amyloidosisalliance.local\/les-progres-dans-lamylose\/"},"modified":"2026-09-29T15:32:18","modified_gmt":"2026-09-29T13:32:18","slug":"les-progres-dans-lamylose","status":"publish","type":"post","link":"https:\/\/www.amyloidosisalliance.org\/fr\/les-progres-dans-lamylose\/","title":{"rendered":"Les progr\u00e8s dans l\u2019amylose"},"content":{"rendered":"<\/p>\n\n\n<p class=\"wp-block-paragraph\">Pendant pr\u00e8s de 150 ans apr\u00e8s sa d\u00e9couverte, l\u2019amylose a \u00e9t\u00e9 consid\u00e9r\u00e9e comme incurable. Historiquement, la complexit\u00e9 de la maladie a frein\u00e9 la recherche\u00a0: pourquoi investir du temps et de l\u2019argent dans la recherche sur une maladie aussi complexe\u202f?<\/p>\n<p>\n<\/p><\/p>\n\n\n<p class=\"wp-block-paragraph\">L\u2019amylose est en effet difficile \u00e0 diagnostiquer pour plusieurs raisons, notamment parce qu\u2019il en existe 36 sous-types connus. Onze d\u2019entre eux touchent directement le c\u0153ur, tandis que d\u2019autres touchent d\u2019autres parties du corps.<\/p>\n<p>\n<\/p><\/p>\n\n\n<p class=\"wp-block-paragraph\">Heureusement pour nos patients, la prise en charge de l\u2019amylose a beaucoup \u00e9volu\u00e9 en leur faveur au cours des derni\u00e8res d\u00e9cennies, sur trois plans\u00a0: le diagnostic, le traitement et la recherche.<\/p>\n<p>\n<\/p><\/p>\n\n\n<p class=\"wp-block-paragraph\">Cet article s\u2019appuie sur l\u2019\u00e9tude\u00a0: <a href=\"https:\/\/utswmed.org\/medblog\/cardiac-amyloidosis-doctor\/?fbclid=IwAR3jL4Ts9w6au4L9XCH9HFb0dWNg94G_2MQzQ76Ax23Tu22s9cC5nHcT2RQ\" target=\"_blank\" rel=\"noreferrer noopener\" style=\"font-family: var( --e-global-typography-text-font-family ), Sans-serif; font-weight: var( --e-global-typography-text-font-weight ); background-color: white; letter-spacing: 0.2px;\">Three parallel advances usher in new age of cardiac amyloidosis care<\/a>.<\/p>\n<p>\n<\/p><\/p>\n\n\n<h2 class=\"wp-block-heading\">Le diagnostic<\/h2>\n<p>\n<\/p><\/p>\n\n\n<p class=\"wp-block-paragraph\">Jusqu\u2019ici, le diagnostic de l\u2019amylose cardiaque ATTR (ATTR-CA) n\u00e9cessitait une biopsie endomyocardique. D\u00e9sormais, les progr\u00e8s des technologies de diagnostic permettent de confirmer une amylose ATTR, une fois l\u2019amylose AL \u00e9cart\u00e9e, par diff\u00e9rents moyens, dont l\u2019imagerie et les analyses de sang et d\u2019urine.<\/p>\n<p>\n<\/p><\/p>\n\n\n<p class=\"wp-block-paragraph\">La premi\u00e8re \u00e9tape du diagnostic est la recherche de cha\u00eenes l\u00e9g\u00e8res anormales. Pour r\u00e9v\u00e9ler ces anomalies, une prise de sang peut d\u00e9j\u00e0 signaler une urgence diagnostique. Des technologies comme l\u2019\u00e9lectrocardiogramme ou l\u2019\u00e9chocardiographie, combin\u00e9es, peuvent apporter des \u00e9l\u00e9ments vraiment solides en faveur d\u2019une amylose cardiaque. Ce n\u2019est que lorsque l\u2019amylose AL ne peut pas \u00eatre \u00e9cart\u00e9e qu\u2019une biopsie endomyocardique doit \u00eatre r\u00e9alis\u00e9e pour d\u00e9tecter la maladie. Lorsque l\u2019amylose AL est \u00e9cart\u00e9e, d\u2019autres examens comme la scintigraphie, les analyses de sang et d\u2019urine ou l\u2019IRM cardiaque peuvent \u00eatre r\u00e9alis\u00e9s.<\/p>\n<p>\n<\/p><\/p>\n\n\n<h2 class=\"wp-block-heading\">Traitement<\/h2>\n<p>\n<\/p><\/p>\n\n\n<p class=\"wp-block-paragraph\">Pour obtenir les meilleurs r\u00e9sultats dans le traitement de l\u2019amylose, un traitement pr\u00e9coce et une prise en charge coordonn\u00e9e sont essentiels. Certains h\u00f4pitaux disposent d\u2019\u00e9quipements importants et de m\u00e9decins sp\u00e9cialis\u00e9s pour tenter de vaincre cette maladie.<\/p>\n<p>\n<\/p><\/p>\n\n\n<p class=\"wp-block-paragraph\">Parmi les associations de traitements efficaces aujourd\u2019hui figure l\u2019association d\u2019une chimioth\u00e9rapie et d\u2019anticorps monoclonaux, comme le CyBorD et le daratumumab. L\u2019arriv\u00e9e de certains m\u00e9dicaments a aussi permis de stabiliser la maladie chez certains patients. Par exemple, la FDA a autoris\u00e9 l\u2019inotersen et le patisiran en 2018 pour l\u2019amylose ATTR h\u00e9r\u00e9ditaire, puis le tafamidis en 2019. Ce type de traitement ne gu\u00e9rit \u00e9videmment pas la maladie, mais il la ralentit et r\u00e9duit le risque d\u2019hospitalisation ou de d\u00e9c\u00e8s.<\/p>\n<p>\n<\/p><\/p>\n\n\n<h2 class=\"wp-block-heading\">Recherche<\/h2>\n<p>\n<\/p><\/p>\n\n\n<p class=\"wp-block-paragraph\">Apr\u00e8s des ann\u00e9es presque sans recherche sur l\u2019amylose, on peut dire aujourd\u2019hui qu\u2019elle est en plein essor.<\/p>\n<p>\n<\/p><\/p>\n\n\n<p class=\"wp-block-paragraph\">De plus en plus d\u2019essais cliniques sont men\u00e9s pour mieux conna\u00eetre la maladie afin de la vaincre. Parmi les plus marquants\u00a0:<\/p>\n<p>\n<\/p><\/p>\n\n<\/p>\n<ul class=\"wp-block-list\">\n<li style=\"list-style-type: none;\">\n<ul>\n\n\n\n\n<ul>\n<li style=\"list-style-type: none;\">\n<ul>\n<li>\u00c9tude de l\u2019anticorps monoclonal CAEL-101<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>\n<\/p>\n<\/p>\n<p>\n\n\n<ul>\n<li style=\"list-style-type: none;\">\n<ul>\n<li>Cardio TTRANSFORM<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>\n<\/p>\n<\/p>\n<p>\n\n\n<ul>\n<li style=\"list-style-type: none;\">\n<ul>\n<li>S\u00e9curit\u00e9, efficacit\u00e9 et pharmacocin\u00e9tique du tafamidis<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>\n<\/p>\n<\/p>\n<p>\n<\/p>\n\n\n<p class=\"wp-block-paragraph\">Cette nouvelle \u00e8re de l\u2019amylose apporte de l\u2019espoir aux patients. Nous esp\u00e9rons qu\u2019\u00e0 l\u2019avenir, l\u2019errance diagnostique sera derri\u00e8re nous et que nous pourrons d\u00e9couvrir des traitements de plus en plus efficaces contre l\u2019amylose.<\/p>\n<p>\n<\/p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Diagnostic, traitement et recherche\u00a0: comment la prise en charge de l\u2019amylose cardiaque a \u00e9volu\u00e9 au cours des derni\u00e8res d\u00e9cennies, \u00e0 partir d\u2019une revue de trois avanc\u00e9es parall\u00e8les.<\/p>\n","protected":false},"author":1,"featured_media":1720,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[24],"tags":[],"class_list":["post-1719","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-actualites"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Les progr\u00e8s 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