{"id":1427,"date":"2026-07-07T14:51:22","date_gmt":"2026-07-07T12:51:22","guid":{"rendered":"https:\/\/amyloidosisalliance.local\/types-damylose\/"},"modified":"2026-09-29T11:03:59","modified_gmt":"2026-09-29T09:03:59","slug":"types-damylose","status":"publish","type":"page","link":"https:\/\/www.amyloidosisalliance.org\/fr\/types-damylose\/","title":{"rendered":"Types d\u2019amylose"},"content":{"rendered":"\n<nav aria-label=\"Breadcrumb\" class=\"wp-block-group aa-breadcrumb is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"aa-inner\"><a href=\"\/\">Accueil<\/a><span class=\"aa-breadcrumb__sep\">\u203a<\/span><span class=\"aa-breadcrumb__label\">Amylose<\/span><span class=\"aa-breadcrumb__sep\">\u203a<\/span><span class=\"aa-breadcrumb__current\">Types d\u2019amylose<\/span><\/div>\n<\/nav>\n\n<section class=\"wp-block-group aa-page-hero is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-inner is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-page-hero__grid is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"aa-overline wp-block-paragraph\">Amylose<\/p>\n\n\n\n<h1 class=\"wp-block-heading\">Types d\u2019amylose<\/h1>\n\n\n\n<p class=\"aa-lead wp-block-paragraph\">L\u2019amylose n\u2019est pas une maladie unique mais une famille de maladies distinctes, chacune d\u00e9finie par le type de prot\u00e9ine qui se replie mal et par les organes qu\u2019elle touche. Comprendre chaque type est la premi\u00e8re \u00e9tape vers un diagnostic pr\u00e9cis et un traitement cibl\u00e9.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-page-hero__photo is-layout-flow wp-block-group-is-layout-flow\">\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"1080\" height=\"1350\" src=\"https:\/\/www.amyloidosisalliance.org\/wp-content\/uploads\/2026\/09\/Design-sans-titre.zip-6.jpg\" alt=\"\" class=\"wp-image-1190\" srcset=\"https:\/\/www.amyloidosisalliance.org\/wp-content\/uploads\/2026\/09\/Design-sans-titre.zip-6.jpg 1080w, https:\/\/www.amyloidosisalliance.org\/wp-content\/uploads\/2026\/09\/Design-sans-titre.zip-6-240x300.jpg 240w, https:\/\/www.amyloidosisalliance.org\/wp-content\/uploads\/2026\/09\/Design-sans-titre.zip-6-819x1024.jpg 819w, https:\/\/www.amyloidosisalliance.org\/wp-content\/uploads\/2026\/09\/Design-sans-titre.zip-6-768x960.jpg 768w\" sizes=\"auto, (max-width: 1080px) 100vw, 1080px\" \/><\/figure>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n\n<nav aria-label=\"Section navigation\" class=\"wp-block-group aa-anchorband is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-inner is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-columns aa-anchor-cols is-layout-flex wp-container-core-columns-is-layout-b2e659ba wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column aa-anchor-item is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"num wp-block-paragraph\">01<\/p>\n\n\n\n<p class=\"lbl wp-block-paragraph\"><a href=\"#diversity\">La diversit\u00e9<\/a><\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column aa-anchor-item is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"num wp-block-paragraph\">02<\/p>\n\n\n\n<p class=\"lbl wp-block-paragraph\"><a href=\"#al\">Amylose AL<\/a><\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column aa-anchor-item is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"num wp-block-paragraph\">03<\/p>\n\n\n\n<p class=\"lbl wp-block-paragraph\"><a href=\"#attr\">Amylose ATTR<\/a><\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column aa-anchor-item is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"num wp-block-paragraph\">04<\/p>\n\n\n\n<p class=\"lbl wp-block-paragraph\"><a href=\"#aa\">Amylose AA<\/a><\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column aa-anchor-item is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"num wp-block-paragraph\">05<\/p>\n\n\n\n<p class=\"lbl wp-block-paragraph\"><a href=\"#rarer\">Types plus rares<\/a><\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column aa-anchor-item is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"num wp-block-paragraph\">06<\/p>\n\n\n\n<p class=\"lbl wp-block-paragraph\"><a href=\"#localized\">Localis\u00e9e<\/a><\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column aa-anchor-item is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"num wp-block-paragraph\">07<\/p>\n\n\n\n<p class=\"lbl wp-block-paragraph\"><a href=\"#compare\">Comparer les types<\/a><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/nav>\n\n<section id=\"diversity\" class=\"wp-block-group aa-section aa-section--white aa-intro is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-inner is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"aa-section-num wp-block-paragraph\">01<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">La grande diversit\u00e9 de l\u2019amylose<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Plus de 40 prot\u00e9ines pr\u00e9curseurs humaines sont connues pour former des d\u00e9p\u00f4ts amylo\u00efdes. L\u2019amylose est class\u00e9e selon la prot\u00e9ine qui forme les fibrilles. Les formes syst\u00e9miques les plus fr\u00e9quentes, AL, ATTR et AA, font chacune intervenir des prot\u00e9ines pr\u00e9curseurs diff\u00e9rentes, touchent des organes diff\u00e9rents et demandent des strat\u00e9gies de traitement fondamentalement diff\u00e9rentes.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Comme les sympt\u00f4mes ressemblent souvent \u00e0 ceux de maladies plus fr\u00e9quentes, un typage correct est essentiel et n\u00e9cessite des examens sp\u00e9cialis\u00e9s. Un typage pr\u00e9coce et pr\u00e9cis est le fondement d\u2019une prise en charge efficace.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-intro__media is-layout-flow wp-block-group-is-layout-flow\">\n<figure class=\"aa-protein\" role=\"img\" aria-label=\"Illustration : une prot\u00e9ine correctement repli\u00e9e se replie mal et s\u2019empile en fibrilles amylo\u00efdes\">\n\t\t\t\t<svg viewbox=\"0 0 480 360\" aria-hidden=\"true\" focusable=\"false\">\n\t\t\t\t\t<defs>\n\t\t\t\t\t\t<lineargradient id=\"aa-prot-core\" x1=\"0\" y1=\"0\" x2=\"1\" y2=\"1\">\n\t\t\t\t\t\t\t<stop offset=\"0%\" stop-color=\"#167a82\"><\/stop>\n\t\t\t\t\t\t\t<stop offset=\"100%\" stop-color=\"#00666d\"><\/stop>\n\t\t\t\t\t\t<\/lineargradient>\n\t\t\t\t\t\t<lineargradient id=\"aa-prot-fib\" x1=\"0\" y1=\"0\" x2=\"1\" y2=\"0\">\n\t\t\t\t\t\t\t<stop offset=\"0%\" stop-color=\"#f6a955\"><\/stop>\n\t\t\t\t\t\t\t<stop offset=\"100%\" stop-color=\"#f39325\"><\/stop>\n\t\t\t\t\t\t<\/lineargradient>\n\t\t\t\t\t<\/defs>\n\n\t\t\t\t\t<!-- Prot\u00e9ine correctement repli\u00e9e : h\u00e9lice compacte -->\n\t\t\t\t\t<g transform=\"translate(96 130)\">\n\t\t\t\t\t\t<circle r=\"62\" fill=\"#eaf3f3\"><\/circle>\n\t\t\t\t\t\t<path d=\"M-34 26 C-46 2 -26 -14 -6 -8 C14 -2 30 -16 22 -34\" fill=\"none\" stroke=\"url(#aa-prot-core)\" stroke-width=\"9\" stroke-linecap=\"round\"><\/path>\n\t\t\t\t\t\t<path d=\"M-26 40 C-4 44 18 30 26 10\" fill=\"none\" stroke=\"url(#aa-prot-core)\" stroke-width=\"9\" stroke-linecap=\"round\" opacity=\"0.55\"><\/path>\n\t\t\t\t\t\t<circle cx=\"22\" cy=\"-34\" r=\"7\" fill=\"#00666d\"><\/circle>\n\t\t\t\t\t\t<circle cx=\"-34\" cy=\"26\" r=\"7\" fill=\"#00666d\"><\/circle>\n\t\t\t\t\t<\/g>\n\n\t\t\t\t\t<!-- Transition -->\n\t\t\t\t\t<g stroke=\"#c9d2d6\" stroke-width=\"2\" stroke-linecap=\"round\">\n\t\t\t\t\t\t<line x1=\"176\" y1=\"130\" x2=\"212\" y2=\"130\" stroke-dasharray=\"2 8\"><\/line>\n\t\t\t\t\t\t<path d=\"M206 122 L216 130 L206 138\" fill=\"none\"><\/path>\n\t\t\t\t\t<\/g>\n\n\t\t\t\t\t<!-- Prot\u00e9ine mal repli\u00e9e : feuillets b\u00eata empil\u00e9s -->\n\t\t\t\t\t<g transform=\"translate(300 130)\">\n\t\t\t\t\t\t<g fill=\"none\" stroke=\"url(#aa-prot-fib)\" stroke-width=\"8\" stroke-linecap=\"round\">\n\t\t\t\t\t\t\t<path d=\"M-56 -34 L-20 -34 L-20 -14 L16 -14 L16 -34 L52 -34\"><\/path>\n\t\t\t\t\t\t\t<path d=\"M-56 -6 L-20 -6 L-20 14 L16 14 L16 -6 L52 -6\"><\/path>\n\t\t\t\t\t\t\t<path d=\"M-56 22 L-20 22 L-20 42 L16 42 L16 22 L52 22\"><\/path>\n\t\t\t\t\t\t<\/g>\n\t\t\t\t\t<\/g>\n\n\t\t\t\t\t<!-- Fibrille amylo\u00efde : les feuillets s'assemblent en filament -->\n\t\t\t\t\t<g transform=\"translate(240 268)\" fill=\"none\" stroke-linecap=\"round\">\n\t\t\t\t\t\t<path d=\"M-190 0 C-150 -22 -110 22 -70 0 C-30 -22 10 22 50 0 C90 -22 130 22 170 0\" stroke=\"url(#aa-prot-fib)\" stroke-width=\"7\"><\/path>\n\t\t\t\t\t\t<path d=\"M-190 14 C-150 -8 -110 36 -70 14 C-30 -8 10 36 50 14 C90 -8 130 36 170 14\" stroke=\"url(#aa-prot-fib)\" stroke-width=\"7\" opacity=\"0.45\"><\/path>\n\t\t\t\t\t<\/g>\n\n\t\t\t\t\t<text x=\"96\" y=\"222\" text-anchor=\"middle\" fill=\"#5a6a73\" font-family=\"'JetBrains Mono', ui-monospace, monospace\" font-size=\"12\" letter-spacing=\"1.4\">REPLI\u00c9E<\/text>\n\t\t\t\t\t<text x=\"300\" y=\"222\" text-anchor=\"middle\" fill=\"#5a6a73\" font-family=\"'JetBrains Mono', ui-monospace, monospace\" font-size=\"12\" letter-spacing=\"1.4\">MAL REPLI\u00c9E<\/text>\n\t\t\t\t\t<text x=\"240\" y=\"320\" text-anchor=\"middle\" fill=\"#5a6a73\" font-family=\"'JetBrains Mono', ui-monospace, monospace\" font-size=\"12\" letter-spacing=\"1.4\">FIBRILLE AMYLO\u00cfDE<\/text>\n\t\t\t\t<\/svg>\n\t\t\t<\/figure>\n<\/div>\n<\/div>\n<\/section>\n\n<section id=\"al\" class=\"wp-block-group aa-section aa-section--cream aa-type is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-inner is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-type-split aa-type-split--photo-left is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-type-photo is-layout-flow wp-block-group-is-layout-flow\">\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" src=\"\/wp-content\/themes\/amyloidosis-alliance\/assets\/images\/disease\/al-card.svg\" alt=\"\"\/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-type-text is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"aa-type-label wp-block-paragraph\">02 \u00b7 Syst\u00e9mique<\/p>\n\n\n\n<h2 class=\"wp-block-heading aa-type-h\">Amylose AL<\/h2>\n\n\n\n<p class=\"aa-type-p wp-block-paragraph\">L\u2019amylose AL (\u00e0 cha\u00eenes l\u00e9g\u00e8res) est due \u00e0 une prolif\u00e9ration anormale de plasmocytes de la moelle osseuse qui produisent des cha\u00eenes l\u00e9g\u00e8res d\u2019immunoglobulines mal repli\u00e9es. Ces fragments se d\u00e9posent sous forme de fibrilles amylo\u00efdes, principalement dans le c\u0153ur et les reins, mais potentiellement dans n\u2019importe quel organe.<\/p>\n\n\n\n<p class=\"aa-type-p wp-block-paragraph\">C\u2019est la forme la plus fr\u00e9quente d\u2019amylose syst\u00e9mique dans les pays d\u00e9velopp\u00e9s. Le traitement cible la maladie plasmocytaire sous-jacente, g\u00e9n\u00e9ralement par des protocoles de chimioth\u00e9rapie proches de ceux du my\u00e9lome multiple.<\/p>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button aa-btn aa-btn--teal\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.amyloidosisalliance.org\/fr\/types-damylose\/amylose-al\/\">D\u00e9couvrir l\u2019amylose AL \u2192<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n\n<section id=\"attr\" class=\"wp-block-group aa-section aa-section--white aa-type is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-inner is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-type-split aa-type-split--photo-right is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"aa-section-num wp-block-paragraph\">03 \u00b7 Syst\u00e9mique<\/p>\n\n\n\n<h2 class=\"wp-block-heading aa-type-h\">Amylose ATTR<\/h2>\n\n\n\n<p class=\"aa-type-p wp-block-paragraph\">L\u2019amylose ATTR (\u00e0 transthyr\u00e9tine) survient lorsque la transthyr\u00e9tine, une prot\u00e9ine produite par le foie, devient instable et se replie mal. Elle touche surtout le c\u0153ur et le syst\u00e8me nerveux p\u00e9riph\u00e9rique, et existe sous deux formes distinctes, aux causes et aux parcours de traitement diff\u00e9rents.<\/p>\n\n\n\n<div class=\"wp-block-group aa-subtype-list is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-subtype-row is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"aa-subtype-row__name wp-block-paragraph\">ATTR wild-type<\/p>\n\n\n\n<p class=\"aa-subtype-row__desc wp-block-paragraph\">Survient spontan\u00e9ment avec l\u2019\u00e2ge, et n\u2019est pas h\u00e9r\u00e9ditaire. Se pr\u00e9sente le plus souvent sous forme de cardiomyopathie chez les hommes \u00e2g\u00e9s. De mieux en mieux reconnue gr\u00e2ce aux progr\u00e8s de l\u2019imagerie cardiaque.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button aa-btn aa-btn--teal aa-btn--sm\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.amyloidosisalliance.org\/fr\/types-damylose\/amylose-attrwt\/\">D\u00e9couvrir \u2192<\/a><\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-subtype-row is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"aa-subtype-row__name wp-block-paragraph\">ATTR h\u00e9r\u00e9ditaire<\/p>\n\n\n\n<p class=\"aa-subtype-row__desc wp-block-paragraph\">Due \u00e0 une mutation g\u00e9n\u00e9tique du g\u00e8ne TTR. Transmise sur le mode autosomique dominant. L\u2019\u00e2ge de d\u00e9but et les organes touch\u00e9s varient selon la mutation\u202f; la neuropathie en est un signe distinctif.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button aa-btn aa-btn--teal aa-btn--sm\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.amyloidosisalliance.org\/fr\/types-damylose\/amylose-attrv\/\">D\u00e9couvrir \u2192<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-type-photo is-layout-flow wp-block-group-is-layout-flow\">\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" src=\"\/wp-content\/themes\/amyloidosis-alliance\/assets\/images\/disease\/attr-card.svg\" alt=\"\"\/><\/figure>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n\n<section id=\"aa\" class=\"wp-block-group aa-section aa-section--cream aa-type is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-inner is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-type-split aa-type-split--photo-left is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-type-photo is-layout-flow wp-block-group-is-layout-flow\">\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" src=\"\/wp-content\/themes\/amyloidosis-alliance\/assets\/images\/disease\/aa-card.svg\" alt=\"\"\/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-type-text is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"aa-type-label wp-block-paragraph\">04 \u00b7 Syst\u00e9mique<\/p>\n\n\n\n<h2 class=\"wp-block-heading aa-type-h\">Amylose AA<\/h2>\n\n\n\n<p class=\"aa-type-p wp-block-paragraph\">L\u2019amylose AA est une complication secondaire d\u2019une inflammation syst\u00e9mique persistante. La prot\u00e9ine en cause, la prot\u00e9ine amylo\u00efde A s\u00e9rique (SAA), est une prot\u00e9ine de la phase aigu\u00eb produite par le foie en r\u00e9ponse \u00e0 des \u00e9tats inflammatoires chroniques comme la polyarthrite rhumato\u00efde, les maladies inflammatoires chroniques de l\u2019intestin ou les infections chroniques.<\/p>\n\n\n\n<p class=\"aa-type-p wp-block-paragraph\">Les reins sont la cible principale, avec une prot\u00e9inurie et une insuffisance r\u00e9nale progressive. Le traitement vise \u00e0 contr\u00f4ler la maladie inflammatoire ou infectieuse sous-jacente et \u00e0 supprimer la production de prot\u00e9ine amylo\u00efde A s\u00e9rique (SAA).<\/p>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button aa-btn aa-btn--teal\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.amyloidosisalliance.org\/fr\/types-damylose\/amylose-aa\/\">D\u00e9couvrir l\u2019amylose AA \u2192<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n\n<section id=\"rarer\" class=\"wp-block-group aa-section aa-section--white aa-type is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-inner is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-type-split aa-type-split--photo-right is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"aa-section-num wp-block-paragraph\">05<\/p>\n\n\n\n<h2 class=\"wp-block-heading aa-type-h\">Types h\u00e9r\u00e9ditaires plus rares<\/h2>\n\n\n\n<p class=\"aa-type-p wp-block-paragraph\">Au-del\u00e0 de l\u2019amylose ATTR, d\u2019autres mutations g\u00e9n\u00e9tiques sont \u00e0 l\u2019origine de formes h\u00e9r\u00e9ditaires plus rares d\u2019amylose syst\u00e9mique. Chacune est d\u00e9finie par sa prot\u00e9ine pr\u00e9curseur et a son propre profil d\u2019atteinte des organes. Le test g\u00e9n\u00e9tique est indispensable au diagnostic et a des cons\u00e9quences pour les membres de la famille.<\/p>\n\n\n\n<div class=\"wp-block-group aa-subtype-list is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-rare-row is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"aa-rare-row__name wp-block-paragraph\">AAPOA1<\/p>\n\n\n\n<p class=\"aa-rare-row__desc wp-block-paragraph\">Mutation de l\u2019apolipoprot\u00e9ine A-I. Touche les reins, le foie et les nerfs p\u00e9riph\u00e9riques. Transmission autosomique dominante.<\/p>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button aa-btn aa-btn--teal aa-btn--sm\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.amyloidosisalliance.org\/fr\/types-damylose\/amyloses-hereditaires-rares\/\">D\u00e9couvrir \u2192<\/a><\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-rare-row is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"aa-rare-row__name wp-block-paragraph\">AGEL<\/p>\n\n\n\n<p class=\"aa-rare-row__desc wp-block-paragraph\">Mutation de la gelsoline. Provoque surtout une neuropathie cr\u00e2nienne et une dystrophie corn\u00e9enne grillag\u00e9e. Plus fr\u00e9quente en Finlande.<\/p>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button aa-btn aa-btn--teal aa-btn--sm\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.amyloidosisalliance.org\/fr\/types-damylose\/amyloses-hereditaires-rares\/\">D\u00e9couvrir \u2192<\/a><\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-rare-row is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"aa-rare-row__name wp-block-paragraph\">ALYS<\/p>\n\n\n\n<p class=\"aa-rare-row__desc wp-block-paragraph\">Mutation du lysozyme. Atteinte surtout r\u00e9nale, avec des d\u00e9p\u00f4ts dans le foie. Des cas britanniques ont \u00e9t\u00e9 d\u00e9crits historiquement.<\/p>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button aa-btn aa-btn--teal aa-btn--sm\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.amyloidosisalliance.org\/fr\/types-damylose\/amyloses-hereditaires-rares\/\">D\u00e9couvrir \u2192<\/a><\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-rare-row is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"aa-rare-row__name wp-block-paragraph\">AFib<\/p>\n\n\n\n<p class=\"aa-rare-row__desc wp-block-paragraph\">Mutation de la cha\u00eene alpha du fibrinog\u00e8ne. Maladie exclusivement r\u00e9nale\u202f; l\u2019une des formes h\u00e9r\u00e9ditaires les plus fr\u00e9quentes en Europe de l\u2019Ouest.<\/p>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button aa-btn aa-btn--teal aa-btn--sm\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.amyloidosisalliance.org\/fr\/types-damylose\/amyloses-hereditaires-rares\/\">D\u00e9couvrir \u2192<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-type-photo is-layout-flow wp-block-group-is-layout-flow\">\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" src=\"\/wp-content\/themes\/amyloidosis-alliance\/assets\/images\/disease\/rare-card.svg\" alt=\"\"\/><\/figure>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n\n<section id=\"localized\" class=\"wp-block-group aa-section aa-section--forest aa-type is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-inner is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-type-split aa-type-split--photo-left is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-type-photo is-layout-flow wp-block-group-is-layout-flow\">\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" src=\"\/wp-content\/themes\/amyloidosis-alliance\/assets\/images\/disease\/localised-card.svg\" alt=\"\"\/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-type-text is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"aa-type-label wp-block-paragraph\">06 \u00b7 Localis\u00e9e<\/p>\n\n\n\n<h2 class=\"wp-block-heading aa-type-h\">Amylose localis\u00e9e<\/h2>\n\n\n\n<p class=\"aa-type-p wp-block-paragraph\">Contrairement aux formes syst\u00e9miques, l\u2019amylose localis\u00e9e est limit\u00e9e \u00e0 un seul organe ou tissu, le plus souvent les voies respiratoires, la peau, la vessie ou l\u2019orbite. La substance amylo\u00efde est produite sur place par des plasmocytes r\u00e9sidents et ne se diffuse pas dans l\u2019organisme.<\/p>\n\n\n\n<p class=\"aa-type-p wp-block-paragraph\">Le pronostic est g\u00e9n\u00e9ralement plus favorable que celui des formes syst\u00e9miques, car le fonctionnement des organes vitaux est rarement compromis. La prise en charge d\u00e9pend du site touch\u00e9 et de l\u2019\u00e9tendue des l\u00e9sions locales.<\/p>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button aa-btn aa-btn--primary\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.amyloidosisalliance.org\/fr\/types-damylose\/amylose-localisee\/\">D\u00e9couvrir \u2192<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n\n<section id=\"compare\" class=\"wp-block-group aa-section aa-section--cream aa-compare-sec is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-inner is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-centered-head is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"aa-section-num wp-block-paragraph\">07<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Comparer les types<\/h2>\n\n\n\n<div class=\"aa-divider-dot\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">Un aper\u00e7u rapide des principaux types d\u2019amylose\u00a0: prot\u00e9ine, principaux organes touch\u00e9s, approche th\u00e9rapeutique, et o\u00f9 en savoir plus.<\/p>\n<\/div>\n\n\n\n<figure class=\"wp-block-table aa-compare\"><table><thead><tr><th>Type<\/th><th>Prot\u00e9ine<\/th><th>Principaux organes<\/th><th>Approche th\u00e9rapeutique<\/th><th>En savoir plus<\/th><\/tr><\/thead><tbody><tr><td>AL<\/td><td>Cha\u00eenes l\u00e9g\u00e8res d\u2019immunoglobulines<\/td><td>C\u0153ur, reins, foie, nerfs, tissus mous<\/td><td>Chimioth\u00e9rapie dirig\u00e9e contre les plasmocytes\u202f; greffe de cellules souches chez les patients \u00e9ligibles<\/td><td><a class=\"aa-compare__link\" href=\"https:\/\/www.amyloidosisalliance.org\/fr\/types-damylose\/amylose-al\/\">Amylose AL \u2192<\/a><\/td><\/tr><tr><td>ATTR, wild-type<\/td><td>Transthyr\u00e9tine (wild-type)<\/td><td>C\u0153ur (cardiomyopathie)<\/td><td>Stabilisation de la TTR et prise en charge cardiaque de support\u202f; les indications autoris\u00e9es et la disponibilit\u00e9 varient d\u2019un pays \u00e0 l\u2019autre.<\/td><td><a class=\"aa-compare__link\" href=\"https:\/\/www.amyloidosisalliance.org\/fr\/types-damylose\/amylose-attrwt\/\">Amylose ATTRwt \u2192<\/a><\/td><\/tr><tr><td>ATTR, h\u00e9r\u00e9ditaire<\/td><td>Transthyr\u00e9tine (mut\u00e9e)<\/td><td>Nerfs p\u00e9riph\u00e9riques, c\u0153ur (selon la mutation)<\/td><td>Silenceurs de la TTR (ARNsi, ASO)\u202f; stabilisateurs\u202f; greffe de foie (certaines mutations)<\/td><td><a class=\"aa-compare__link\" href=\"https:\/\/www.amyloidosisalliance.org\/fr\/types-damylose\/amylose-attrv\/\">Amylose ATTRv \u2192<\/a><\/td><\/tr><tr><td>AA<\/td><td>Prot\u00e9ine amylo\u00efde A s\u00e9rique (SAA)<\/td><td>Reins, foie, rate<\/td><td>Contr\u00f4le de la maladie inflammatoire sous-jacente\u202f; anti-IL-1<\/td><td><a class=\"aa-compare__link\" href=\"https:\/\/www.amyloidosisalliance.org\/fr\/types-damylose\/amylose-aa\/\">Amylose AA \u2192<\/a><\/td><\/tr><tr><td>H\u00e9r\u00e9ditaires plus rares<\/td><td>ApoA-I, gelsoline, lysozyme, fibrinog\u00e8ne\u2026<\/td><td>Selon le type (reins, nerfs, foie)<\/td><td>Traitement de support\u202f; greffe d\u2019organe dans certains cas<\/td><td><a class=\"aa-compare__link\" href=\"https:\/\/www.amyloidosisalliance.org\/fr\/types-damylose\/amyloses-hereditaires-rares\/\">Amyloses h\u00e9r\u00e9ditaires rares \u2192<\/a><\/td><\/tr><\/tbody><\/table><\/figure>\n<\/div>\n<\/section>\n\n<section class=\"wp-block-group aa-next aa-next--split is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-inner is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-next__head is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"aa-section-num wp-block-paragraph\">Continuer<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u00c0 lire ensuite<\/h2>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-next__grid is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-next-card is-layout-flow wp-block-group-is-layout-flow\">\n<h3 class=\"wp-block-heading\"><a href=\"https:\/\/www.amyloidosisalliance.org\/fr\/types-damylose\/amylose-al\/\">Amylose AL<\/a><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">La forme syst\u00e9mique la plus fr\u00e9quente dans les pays occidentaux, due \u00e0 des cha\u00eenes l\u00e9g\u00e8res d\u2019immunoglobulines mal repli\u00e9es.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-next-card is-layout-flow wp-block-group-is-layout-flow\">\n<h3 class=\"wp-block-heading\"><a href=\"https:\/\/www.amyloidosisalliance.org\/fr\/types-damylose\/amylose-attr\/\">Amylose ATTR<\/a><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Les formes wild-type et h\u00e9r\u00e9ditaire de l\u2019amylose \u00e0 transthyr\u00e9tine, et ce qui les distingue.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-next-card is-layout-flow wp-block-group-is-layout-flow\">\n<h3 class=\"wp-block-heading\"><a href=\"https:\/\/www.amyloidosisalliance.org\/fr\/types-damylose\/amyloses-hereditaires-rares\/\">Amyloses h\u00e9r\u00e9ditaires rares<\/a><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Les formes h\u00e9r\u00e9ditaires plus rares, les prot\u00e9ines en cause et les organes qu\u2019elles touchent le plus souvent.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n","protected":false},"excerpt":{"rendered":"<p>Accueil\u203aAmylose\u203aTypes d\u2019amylose Amylose Types d\u2019amylose L\u2019amylose n\u2019est pas une maladie unique mais une famille de maladies distinctes, chacune d\u00e9finie par le type de prot\u00e9ine qui se replie mal et par les organes qu\u2019elle touche. Comprendre chaque type est la premi\u00e8re \u00e9tape vers un diagnostic pr\u00e9cis et un traitement cibl\u00e9. 01 La diversit\u00e9 02 Amylose AL [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-1427","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Types d\u2019amylose\u00a0: AL, AA, ATTR et formes rares<\/title>\n<meta name=\"description\" content=\"L\u2019amylose n\u2019est pas une maladie, mais une famille de maladies. 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