{"id":1423,"date":"2026-07-07T14:57:12","date_gmt":"2026-07-07T12:57:12","guid":{"rendered":"https:\/\/amyloidosisalliance.local\/la-maladie\/"},"modified":"2026-09-29T11:03:58","modified_gmt":"2026-09-29T09:03:58","slug":"la-maladie","status":"publish","type":"page","link":"https:\/\/www.amyloidosisalliance.org\/fr\/la-maladie\/","title":{"rendered":"La maladie"},"content":{"rendered":"\n<nav aria-label=\"Breadcrumb\" class=\"wp-block-group aa-breadcrumb is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"aa-inner\"><a href=\"\/\">Accueil<\/a><span class=\"aa-breadcrumb__sep\">\u203a<\/span><span class=\"aa-breadcrumb__label\">Amylose<\/span><span class=\"aa-breadcrumb__sep\">\u203a<\/span><span class=\"aa-breadcrumb__current\">La maladie<\/span><\/div>\n<\/nav>\n\n<section class=\"wp-block-group aa-page-hero is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-inner is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-page-hero__grid is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"aa-overline wp-block-paragraph\">\u00c0 propos de l\u2019amylose<\/p>\n\n\n\n<h1 class=\"wp-block-heading\">La maladie<\/h1>\n\n\n\n<p class=\"aa-lead wp-block-paragraph\">Un guide approfondi sur ce qu\u2019est l\u2019amylose, comment elle se forme, quels organes elle touche et comment elle se traite, \u00e9crit pour les patients, les familles et les professionnels de sant\u00e9.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-page-hero__photo is-layout-flow wp-block-group-is-layout-flow\">\n<figure class=\"aa-protein aa-protein--hero\" role=\"img\" aria-label=\"Illustration : une prot\u00e9ine correctement repli\u00e9e se replie mal et s\u2019empile en fibrilles amylo\u00efdes\">\n\t\t\t\t\t<svg viewbox=\"0 0 480 360\" aria-hidden=\"true\" focusable=\"false\">\n\t\t\t\t\t\t<defs>\n\t\t\t\t\t\t\t\t<lineargradient id=\"aa-prot-core\" x1=\"0\" y1=\"0\" x2=\"1\" y2=\"1\">\n\t\t\t\t\t\t\t\t\t<stop offset=\"0%\" stop-color=\"#167a82\"><\/stop>\n\t\t\t\t\t\t\t\t\t<stop offset=\"100%\" stop-color=\"#00666d\"><\/stop>\n\t\t\t\t\t\t\t\t<\/lineargradient>\n\t\t\t\t\t\t\t\t<lineargradient id=\"aa-prot-fib\" x1=\"0\" y1=\"0\" x2=\"1\" y2=\"0\">\n\t\t\t\t\t\t\t\t\t<stop offset=\"0%\" stop-color=\"#f6a955\"><\/stop>\n\t\t\t\t\t\t\t\t\t<stop offset=\"100%\" stop-color=\"#f39325\"><\/stop>\n\t\t\t\t\t\t\t\t<\/lineargradient>\n\t\t\t\t\t\t<\/defs>\n\n\t\t\t\t\t\t<!-- Prot\u00e9ine correctement repli\u00e9e : h\u00e9lice compacte -->\n\t\t\t\t\t\t<g transform=\"translate(96 130)\">\n\t\t\t\t\t\t\t\t<circle r=\"62\" fill=\"#eaf3f3\"><\/circle>\n\t\t\t\t\t\t\t\t<path d=\"M-34 26 C-46 2 -26 -14 -6 -8 C14 -2 30 -16 22 -34\" fill=\"none\" stroke=\"url(#aa-prot-core)\" stroke-width=\"9\" stroke-linecap=\"round\"><\/path>\n\t\t\t\t\t\t\t\t<path d=\"M-26 40 C-4 44 18 30 26 10\" fill=\"none\" stroke=\"url(#aa-prot-core)\" stroke-width=\"9\" stroke-linecap=\"round\" opacity=\"0.55\"><\/path>\n\t\t\t\t\t\t\t\t<circle cx=\"22\" cy=\"-34\" r=\"7\" fill=\"#00666d\"><\/circle>\n\t\t\t\t\t\t\t\t<circle cx=\"-34\" cy=\"26\" r=\"7\" fill=\"#00666d\"><\/circle>\n\t\t\t\t\t\t<\/g>\n\n\t\t\t\t\t\t<!-- Transition -->\n\t\t\t\t\t\t<g stroke=\"#c9d2d6\" stroke-width=\"2\" stroke-linecap=\"round\">\n\t\t\t\t\t\t\t\t<line x1=\"176\" y1=\"130\" x2=\"212\" y2=\"130\" stroke-dasharray=\"2 8\"><\/line>\n\t\t\t\t\t\t\t\t<path d=\"M206 122 L216 130 L206 138\" fill=\"none\"><\/path>\n\t\t\t\t\t\t<\/g>\n\n\t\t\t\t\t\t<!-- Prot\u00e9ine mal repli\u00e9e : feuillets b\u00eata empil\u00e9s -->\n\t\t\t\t\t\t<g transform=\"translate(300 130)\">\n\t\t\t\t\t\t\t\t<g fill=\"none\" stroke=\"url(#aa-prot-fib)\" stroke-width=\"8\" stroke-linecap=\"round\">\n\t\t\t\t\t\t\t\t\t<path d=\"M-56 -34 L-20 -34 L-20 -14 L16 -14 L16 -34 L52 -34\"><\/path>\n\t\t\t\t\t\t\t\t\t<path d=\"M-56 -6 L-20 -6 L-20 14 L16 14 L16 -6 L52 -6\"><\/path>\n\t\t\t\t\t\t\t\t\t<path d=\"M-56 22 L-20 22 L-20 42 L16 42 L16 22 L52 22\"><\/path>\n\t\t\t\t\t\t\t\t<\/g>\n\t\t\t\t\t\t<\/g>\n\n\t\t\t\t\t\t<!-- Fibrille amylo\u00efde : les feuillets s'assemblent en filament -->\n\t\t\t\t\t\t<g transform=\"translate(240 268)\" fill=\"none\" stroke-linecap=\"round\">\n\t\t\t\t\t\t\t\t<path d=\"M-190 0 C-150 -22 -110 22 -70 0 C-30 -22 10 22 50 0 C90 -22 130 22 170 0\" stroke=\"url(#aa-prot-fib)\" stroke-width=\"7\"><\/path>\n\t\t\t\t\t\t\t\t<path d=\"M-190 14 C-150 -8 -110 36 -70 14 C-30 -8 10 36 50 14 C90 -8 130 36 170 14\" stroke=\"url(#aa-prot-fib)\" stroke-width=\"7\" opacity=\"0.45\"><\/path>\n\t\t\t\t\t\t<\/g>\n\n\t\t\t\t\t\t<text x=\"96\" y=\"222\" text-anchor=\"middle\" fill=\"#5a6a73\" font-family=\"'JetBrains Mono', ui-monospace, monospace\" font-size=\"12\" letter-spacing=\"1.4\">REPLI\u00c9E<\/text>\n\t\t\t\t\t\t<text x=\"300\" y=\"222\" text-anchor=\"middle\" fill=\"#5a6a73\" font-family=\"'JetBrains Mono', ui-monospace, monospace\" font-size=\"12\" letter-spacing=\"1.4\">MAL REPLI\u00c9E<\/text>\n\t\t\t\t\t\t<text x=\"240\" y=\"320\" text-anchor=\"middle\" fill=\"#5a6a73\" font-family=\"'JetBrains Mono', ui-monospace, monospace\" font-size=\"12\" letter-spacing=\"1.4\">FIBRILLE AMYLO\u00cfDE<\/text>\n\t\t\t\t\t<\/svg>\n\t\t\t\t<\/figure>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n\n<nav aria-label=\"Section navigation\" class=\"wp-block-group aa-anchorband is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-inner is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-columns aa-anchor-cols is-layout-flex wp-container-core-columns-is-layout-b2e659ba wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column aa-anchor-item is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"num wp-block-paragraph\">01<\/p>\n\n\n\n<p class=\"lbl wp-block-paragraph\"><a href=\"#what\">De quoi s\u2019agit-il\u202f?<\/a><\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column aa-anchor-item is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"num wp-block-paragraph\">02<\/p>\n\n\n\n<p class=\"lbl wp-block-paragraph\"><a href=\"#deposits\">D\u00e9p\u00f4ts<\/a><\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column aa-anchor-item is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"num wp-block-paragraph\">03<\/p>\n\n\n\n<p class=\"lbl wp-block-paragraph\"><a href=\"#forms\">Comment elle se forme<\/a><\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column aa-anchor-item is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"num wp-block-paragraph\">04<\/p>\n\n\n\n<p class=\"lbl wp-block-paragraph\"><a href=\"#protein\">De la prot\u00e9ine \u00e0 l\u2019organe<\/a><\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column aa-anchor-item is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"num wp-block-paragraph\">05<\/p>\n\n\n\n<p class=\"lbl wp-block-paragraph\"><a href=\"#symptoms\">Sympt\u00f4mes<\/a><\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column aa-anchor-item is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"num wp-block-paragraph\">06<\/p>\n\n\n\n<p class=\"lbl wp-block-paragraph\"><a href=\"#diversity\">Diversit\u00e9<\/a><\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column aa-anchor-item is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"num wp-block-paragraph\">07<\/p>\n\n\n\n<p class=\"lbl wp-block-paragraph\"><a href=\"#treating\">Traitements<\/a><\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column aa-anchor-item is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"num wp-block-paragraph\">08<\/p>\n\n\n\n<p class=\"lbl wp-block-paragraph\"><a href=\"#living\">Vivre avec<\/a><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/nav>\n\n<section id=\"what\" class=\"wp-block-group aa-section aa-section--white aa-what is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-inner is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"aa-section-num wp-block-paragraph\">01<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Qu\u2019est-ce que l\u2019amylose\u202f?<\/h2>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-what-cols is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-what-col is-layout-flow wp-block-group-is-layout-flow\">\n<h4 class=\"wp-block-heading\">Une maladie du repliement des prot\u00e9ines<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">L\u2019amylose d\u00e9signe un groupe de maladies dans lesquelles certaines prot\u00e9ines se replient mal et s\u2019accumulent dans les tissus et les organes. Ces prot\u00e9ines mal repli\u00e9es forment des fibrilles insolubles, appel\u00e9es fibrilles amylo\u00efdes, qui perturbent la structure et le fonctionnement normaux des organes. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Le processus commence \u00e0 l\u2019\u00e9chelle mol\u00e9culaire\u00a0: une prot\u00e9ine normalement inoffensive devient instable, change de forme et commence \u00e0 s\u2019agr\u00e9ger en structures fibreuses torsad\u00e9es que l\u2019organisme a du mal \u00e0 \u00e9liminer.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-what-col is-layout-flow wp-block-group-is-layout-flow\">\n<h4 class=\"wp-block-heading\">D\u00e9p\u00f4ts dans les organes<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Une fois form\u00e9es, les fibrilles amylo\u00efdes se d\u00e9posent dans la matrice extracellulaire des organes, comblant en quelque sorte les espaces entre les cellules. \u00c0 mesure que les d\u00e9p\u00f4ts s\u2019accumulent, ils rigidifient progressivement les tissus et alt\u00e8rent les fonctions \u00e9lectriques, m\u00e9caniques ou de filtration de l\u2019organe touch\u00e9.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Le c\u0153ur devient rigide et ne peut plus se remplir normalement\u202f; les reins ne parviennent plus \u00e0 retenir les prot\u00e9ines\u202f; les nerfs ne transmettent plus les signaux. L\u2019\u00e9ventail des organes touch\u00e9s et la gravit\u00e9 de l\u2019atteinte varient beaucoup selon le sous-type d\u2019amylose.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n\n<section id=\"deposits\" class=\"wp-block-group aa-section aa-section--cream aa-deposits is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-inner is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-deposits__photo is-layout-flow wp-block-group-is-layout-flow\">\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"683\" src=\"https:\/\/www.amyloidosisalliance.org\/wp-content\/uploads\/2026\/09\/laboratory-microscope-1024x683.jpg\" alt=\"Microscope de laboratoire\" class=\"wp-image-708\" srcset=\"https:\/\/www.amyloidosisalliance.org\/wp-content\/uploads\/2026\/09\/laboratory-microscope-1024x683.jpg 1024w, https:\/\/www.amyloidosisalliance.org\/wp-content\/uploads\/2026\/09\/laboratory-microscope-300x200.jpg 300w, https:\/\/www.amyloidosisalliance.org\/wp-content\/uploads\/2026\/09\/laboratory-microscope-768x512.jpg 768w, https:\/\/www.amyloidosisalliance.org\/wp-content\/uploads\/2026\/09\/laboratory-microscope-1536x1024.jpg 1536w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-group is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"aa-section-num wp-block-paragraph\">02<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Comprendre les d\u00e9p\u00f4ts amylo\u00efdes<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Contrairement \u00e0 la plupart des prot\u00e9ines, qui sont \u00e9limin\u00e9es des tissus lorsqu\u2019elles sont endommag\u00e9es, les fibrilles amylo\u00efdes r\u00e9sistent fortement aux syst\u00e8mes normaux de d\u00e9gradation des prot\u00e9ines. Elles s\u2019accumulent progressivement, et leurs effets s\u2019additionnent avec le temps.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Le diagnostic n\u00e9cessite g\u00e9n\u00e9ralement une biopsie avec coloration au rouge Congo\u00a0: les d\u00e9p\u00f4ts amylo\u00efdes pr\u00e9sentent en lumi\u00e8re polaris\u00e9e une bir\u00e9fringence vert pomme caract\u00e9ristique, l\u2019une des images les plus sp\u00e9cifiques de l\u2019anatomopathologie.<\/p>\n\n\n\n<div class=\"wp-block-group aa-key-idea is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"aa-key-idea__label wp-block-paragraph\">Rep\u00e8re clinique<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Les fibrilles amylo\u00efdes peuvent se d\u00e9poser dans pratiquement n\u2019importe quel organe ou tissu. Leur r\u00e9partition, les organes les plus touch\u00e9s et dans quelle mesure, d\u00e9pend \u00e9troitement du sous-type et d\u00e9termine \u00e0 la fois la pr\u00e9sentation clinique et la strat\u00e9gie de traitement.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n\n<section id=\"forms\" class=\"wp-block-group aa-section aa-section--white aa-forms is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-inner is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-centered-head is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"aa-section-num wp-block-paragraph\">03<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Comment se forme la substance amylo\u00efde<\/h2>\n\n\n\n<div class=\"aa-divider-dot\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">Un aper\u00e7u, \u00e9tape par \u00e9tape, du m\u00e9canisme mol\u00e9culaire qui m\u00e8ne de la production normale d\u2019une prot\u00e9ine \u00e0 l\u2019atteinte des tissus.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-proc-grid is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-proc-step is-layout-flow wp-block-group-is-layout-flow\">\n<span class=\"aa-proc-step__icon\"><svg aria-hidden=\"true\" focusable=\"false\" width=\"24\" height=\"24\" viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><path d=\"M12 3l2.5 6.5L21 12l-6.5 2.5L12 21l-2.5-6.5L3 12l6.5-2.5z\"><\/path><\/svg><\/span>\n\n\n\n<p class=\"aa-proc-step__num wp-block-paragraph\">\u00c9tape 01<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Une prot\u00e9ine normale<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">L\u2019organisme produit une prot\u00e9ine pr\u00e9curseur normale (transthyr\u00e9tine, cha\u00eenes l\u00e9g\u00e8res, SAA ou autres) dans le cadre de processus biologiques ordinaires.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-proc-step is-layout-flow wp-block-group-is-layout-flow\">\n<span class=\"aa-proc-step__icon\"><svg aria-hidden=\"true\" focusable=\"false\" width=\"24\" height=\"24\" viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><polyline points=\"16 3 21 3 21 8\"><\/polyline><line x1=\"4\" y1=\"20\" x2=\"21\" y2=\"3\"><\/line><polyline points=\"21 16 21 21 16 21\"><\/polyline><line x1=\"15\" y1=\"15\" x2=\"21\" y2=\"21\"><\/line><line x1=\"4\" y1=\"4\" x2=\"9\" y2=\"9\"><\/line><\/svg><\/span>\n\n\n\n<p class=\"aa-proc-step__num wp-block-paragraph\">\u00c9tape 02<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Le mauvais repliement<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Sous l\u2019effet d\u2019une mutation g\u00e9n\u00e9tique, d\u2019une surproduction, du vieillissement ou d\u2019une inflammation chronique, la prot\u00e9ine devient structurellement instable et se replie mal.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-proc-step is-layout-flow wp-block-group-is-layout-flow\">\n<span class=\"aa-proc-step__icon\"><svg aria-hidden=\"true\" focusable=\"false\" width=\"24\" height=\"24\" viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><path d=\"M10 13a5 5 0 0 0 7.54.54l3-3a5 5 0 0 0-7.07-7.07l-1.72 1.71\"><\/path><path d=\"M14 11a5 5 0 0 0-7.54-.54l-3 3a5 5 0 0 0 7.07 7.07l1.71-1.71\"><\/path><\/svg><\/span>\n\n\n\n<p class=\"aa-proc-step__num wp-block-paragraph\">\u00c9tape 03<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Les fibrilles amylo\u00efdes<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Les prot\u00e9ines mal repli\u00e9es s\u2019agr\u00e8gent et s\u2019assemblent d\u2019elles-m\u00eames en structures fibrillaires insolubles en feuillets \u03b2, qui r\u00e9sistent \u00e0 la d\u00e9gradation enzymatique.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-proc-step is-layout-flow wp-block-group-is-layout-flow\">\n<span class=\"aa-proc-step__icon\"><svg aria-hidden=\"true\" focusable=\"false\" width=\"24\" height=\"24\" viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><path d=\"M10.29 3.86L1.82 18a2 2 0 0 0 1.71 3h16.94a2 2 0 0 0 1.71-3L13.71 3.86a2 2 0 0 0-3.42 0z\"><\/path><line x1=\"12\" y1=\"9\" x2=\"12\" y2=\"13\"><\/line><line x1=\"12\" y1=\"17\" x2=\"12.01\" y2=\"17\"><\/line><\/svg><\/span>\n\n\n\n<p class=\"aa-proc-step__num wp-block-paragraph\">\u00c9tape 04<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">L\u2019atteinte des organes<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Les fibrilles se d\u00e9posent dans la matrice extracellulaire des organes, d\u00e9placent le tissu normal, rigidifient sa structure et alt\u00e8rent progressivement son fonctionnement.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n\n<section id=\"protein\" class=\"wp-block-group aa-section aa-section--cream aa-protein is-layout-flow wp-block-group-is-layout-flow\" style=\"padding-top:var(--wp--preset--spacing--70);padding-bottom:var(--wp--preset--spacing--70)\">\n<div class=\"wp-block-group aa-inner is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"aa-section-num wp-block-paragraph\">04<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">De la prot\u00e9ine \u00e0 l\u2019atteinte des organes<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Le chemin entre une prot\u00e9ine mal repli\u00e9e et un diagnostic qui bouleverse une vie peut prendre des ann\u00e9es, voire des d\u00e9cennies. Les sympt\u00f4mes sont insidieux et peu sp\u00e9cifiques, souvent attribu\u00e9s au vieillissement ou \u00e0 des maladies plus fr\u00e9quentes, ce qui entra\u00eene un d\u00e9lai de diagnostic de plus de quatre ans en moyenne apr\u00e8s les premiers sympt\u00f4mes.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Comprendre les m\u00e9canismes de l\u2019atteinte des organes (cardiomyopathie, syndrome n\u00e9phrotique, neuropathie p\u00e9riph\u00e9rique) est indispensable pour reconna\u00eetre la maladie t\u00f4t et commencer un traitement avant que les l\u00e9sions ne deviennent irr\u00e9versibles.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-protein__photo is-layout-flow wp-block-group-is-layout-flow\">\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" src=\"\/wp-content\/themes\/amyloidosis-alliance\/assets\/images\/tissue-amyloid.svg\" alt=\"Tissu infiltr&#xE9; par la substance amylo&#xEF;de&#xA0;: &#xE0; gauche, les cellules sont serr&#xE9;es les unes contre les autres dans un tissu sain&#x202F;; vers la droite, elles se r&#xE9;tractent et des d&#xE9;p&#xF4;ts amylo&#xEF;des comblent l&#x2019;espace qui s&#x2019;&#xE9;largit entre elles\"\/><\/figure>\n<\/div>\n<\/div>\n<\/section>\n\n<section id=\"symptoms\" class=\"wp-block-group aa-section aa-section--cream aa-symptoms is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-inner is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-centered-head is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"aa-section-num wp-block-paragraph\">05<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Sympt\u00f4mes et organes touch\u00e9s<\/h2>\n\n\n\n<div class=\"aa-divider-dot\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">Une carte simple du corps pour aider les patients et les professionnels de sant\u00e9 \u00e0 relier les signes d\u2019alerte aux organes touch\u00e9s par l\u2019amylose. Survolez chaque point pour en savoir plus.<\/p>\n<\/div>\n\n\n\n<div class=\"aa-body-card\">\n\t\t\t<div class=\"aa-organ-side\">\n\t\t\t\t<div class=\"aa-organ-label\"><span class=\"aa-organ-label__name\">\u0152il et vision<\/span><h4>D\u00e9p\u00f4ts dans le vitr\u00e9<\/h4><p>Corps flottants, troubles visuels passagers et opacit\u00e9s du vitr\u00e9 dus \u00e0 l\u2019accumulation de prot\u00e9ine amylo\u00efde dans l\u2019\u0153il.<\/p><\/div>\n\t\t\t\t<div class=\"aa-organ-label\"><span class=\"aa-organ-label__name\">Reins<\/span><h4>Prot\u00e9inurie et \u0153d\u00e8mes<\/h4><p>Des prot\u00e9ines qui passent dans les urines, une fonction r\u00e9nale diminu\u00e9e et un gonflement progressif des membres inf\u00e9rieurs d\u00fb au syndrome n\u00e9phrotique.<\/p><\/div>\n\t\t\t\t<div class=\"aa-organ-label\"><span class=\"aa-organ-label__name\">Foie et rate<\/span><h4>Organom\u00e9galie<\/h4><p>Une augmentation de volume du foie ou de la rate, qui provoque une sensation de pl\u00e9nitude, une sati\u00e9t\u00e9 pr\u00e9coce et un bilan h\u00e9patique anormal\u00a0: un signe pr\u00e9coce fr\u00e9quent dans l\u2019amylose AL.<\/p><\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"aa-body-center\">\n\t\t\t\t<div class=\"aa-body-svg-wrap\">\n\t\t\t\t\t<svg class=\"aa-body-svg\" viewbox=\"0 0 200 480\" aria-hidden=\"true\">\n\t\t\t\t\t\t<circle cx=\"100\" cy=\"46\" r=\"34\" fill=\"none\" stroke=\"#00666d\" stroke-width=\"2\" opacity=\"0.4\"><\/circle>\n\t\t\t\t\t\t<rect x=\"90\" y=\"79\" width=\"20\" height=\"18\" rx=\"4\" fill=\"none\" stroke=\"#00666d\" stroke-width=\"1.5\" opacity=\"0.35\"><\/rect>\n\t\t\t\t\t\t<path d=\"M80 97 Q55 102 42 124\" fill=\"none\" stroke=\"#00666d\" stroke-width=\"2\" opacity=\"0.4\" stroke-linecap=\"round\"><\/path>\n\t\t\t\t\t\t<path d=\"M120 97 Q145 102 158 124\" fill=\"none\" stroke=\"#00666d\" stroke-width=\"2\" opacity=\"0.4\" stroke-linecap=\"round\"><\/path>\n\t\t\t\t\t\t<path d=\"M42 124 L38 260 Q68 272 100 274 Q132 272 162 260 L158 124\" fill=\"none\" stroke=\"#00666d\" stroke-width=\"2\" opacity=\"0.4\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><\/path>\n\t\t\t\t\t\t<path d=\"M42 124 Q30 170 24 224\" fill=\"none\" stroke=\"#00666d\" stroke-width=\"2\" opacity=\"0.4\" stroke-linecap=\"round\"><\/path>\n\t\t\t\t\t\t<path d=\"M158 124 Q170 170 176 224\" fill=\"none\" stroke=\"#00666d\" stroke-width=\"2\" opacity=\"0.4\" stroke-linecap=\"round\"><\/path>\n\t\t\t\t\t\t<ellipse cx=\"21\" cy=\"234\" rx=\"10\" ry=\"14\" fill=\"none\" stroke=\"#00666d\" stroke-width=\"1.5\" opacity=\"0.35\"><\/ellipse>\n\t\t\t\t\t\t<ellipse cx=\"179\" cy=\"234\" rx=\"10\" ry=\"14\" fill=\"none\" stroke=\"#00666d\" stroke-width=\"1.5\" opacity=\"0.35\"><\/ellipse>\n\t\t\t\t\t\t<path d=\"M38 260 Q68 278 100 280 Q132 278 162 260\" fill=\"none\" stroke=\"#00666d\" stroke-width=\"2\" opacity=\"0.4\" stroke-linecap=\"round\"><\/path>\n\t\t\t\t\t\t<path d=\"M70 280 Q60 340 58 420\" fill=\"none\" stroke=\"#00666d\" stroke-width=\"2\" opacity=\"0.4\" stroke-linecap=\"round\"><\/path>\n\t\t\t\t\t\t<path d=\"M130 280 Q140 340 142 420\" fill=\"none\" stroke=\"#00666d\" stroke-width=\"2\" opacity=\"0.4\" stroke-linecap=\"round\"><\/path>\n\t\t\t\t\t\t<ellipse cx=\"56\" cy=\"430\" rx=\"14\" ry=\"8\" fill=\"none\" stroke=\"#00666d\" stroke-width=\"1.5\" opacity=\"0.35\"><\/ellipse>\n\t\t\t\t\t\t<ellipse cx=\"144\" cy=\"430\" rx=\"14\" ry=\"8\" fill=\"none\" stroke=\"#00666d\" stroke-width=\"1.5\" opacity=\"0.35\"><\/ellipse>\n\t\t\t\t\t\t<path d=\"M87 165 Q87 155 95 155 Q100 155 100 162 Q100 155 105 155 Q113 155 113 165 Q113 174 100 184 Q87 174 87 165 Z\" fill=\"none\" stroke=\"#f39325\" stroke-width=\"1.5\" opacity=\"0.7\"><\/path>\n\t\t\t\t\t\t<ellipse cx=\"84\" cy=\"215\" rx=\"9\" ry=\"13\" fill=\"none\" stroke=\"#f39325\" stroke-width=\"1.2\" opacity=\"0.6\"><\/ellipse>\n\t\t\t\t\t\t<ellipse cx=\"116\" cy=\"215\" rx=\"9\" ry=\"13\" fill=\"none\" stroke=\"#f39325\" stroke-width=\"1.2\" opacity=\"0.6\"><\/ellipse>\n\t\t\t\t\t\t<line x1=\"100\" y1=\"97\" x2=\"100\" y2=\"270\" stroke=\"#00666d\" stroke-width=\"1\" stroke-dasharray=\"4 4\" opacity=\"0.2\"><\/line>\n\t\t\t\t\t<\/svg>\n\t\t\t\t\t<div class=\"aa-hotspot\" style=\"top:5%;left:58%;transform:translate(-50%,-50%)\"><div class=\"aa-hotspot__dot\"><\/div><div class=\"aa-hotspot-tip aa-tip-left\"><div class=\"aa-hotspot-tip__title\">\u0152il et vision<\/div><p>Les fibrilles amylo\u00efdes se d\u00e9posent dans l\u2019humeur vitr\u00e9e, provoquant des \u00ab\u00a0corps flottants\u00a0\u00bb caract\u00e9ristiques, puis une baisse de la vision. L\u2019amylose du vitr\u00e9 est un signe distinctif de l\u2019amylose ATTR h\u00e9r\u00e9ditaire.<\/p><\/div><\/div>\n\t\t\t\t\t<div class=\"aa-hotspot\" style=\"top:36%;left:43%;transform:translate(-50%,-50%)\"><div class=\"aa-hotspot__dot\"><\/div><div class=\"aa-hotspot-tip aa-tip-right\"><div class=\"aa-hotspot-tip__title\">C\u0153ur<\/div><p>L\u2019amylose cardiaque provoque un \u00e9paississement des parois des ventricules, une cardiomyopathie restrictive et des troubles de la conduction, qui se manifestent par un essoufflement, des \u0153d\u00e8mes et des troubles du rythme.<\/p><\/div><\/div>\n\t\t\t\t\t<div class=\"aa-hotspot\" style=\"top:41%;left:66%;transform:translate(-50%,-50%)\"><div class=\"aa-hotspot__dot\"><\/div><div class=\"aa-hotspot-tip aa-tip-right\"><div class=\"aa-hotspot-tip__title\">Foie et rate<\/div><p>La substance amylo\u00efde infiltre le tissu du foie et de la rate, provoquant une h\u00e9patom\u00e9galie, une \u00e9l\u00e9vation des phosphatases alcalines et une sati\u00e9t\u00e9 pr\u00e9coce. L\u2019atteinte du foie est la plus fr\u00e9quente dans l\u2019amylose AL.<\/p><\/div><\/div>\n\t\t\t\t\t<div class=\"aa-hotspot\" style=\"top:47%;left:50%;transform:translate(-50%,-50%)\"><div class=\"aa-hotspot__dot\"><\/div><div class=\"aa-hotspot-tip aa-tip-right\"><div class=\"aa-hotspot-tip__title\">Reins<\/div><p>Les d\u00e9p\u00f4ts amylo\u00efdes dans les glom\u00e9rules r\u00e9naux alt\u00e8rent la barri\u00e8re de filtration, provoquant une prot\u00e9inurie importante, un syndrome n\u00e9phrotique et une insuffisance r\u00e9nale progressive, surtout dans les amyloses AL et AA.<\/p><\/div><\/div>\n\t\t\t\t\t<div class=\"aa-hotspot\" style=\"top:50%;left:12%;transform:translate(-50%,-50%)\"><div class=\"aa-hotspot__dot\"><\/div><div class=\"aa-hotspot-tip aa-tip-right\"><div class=\"aa-hotspot-tip__title\">Nerfs p\u00e9riph\u00e9riques<\/div><p>Les fibrilles amylo\u00efdes compriment et infiltrent les nerfs p\u00e9riph\u00e9riques, provoquant une neuropathie sensitivomotrice progressive\u00a0: engourdissements, fourmillements et faiblesse qui commencent \u00e0 l\u2019extr\u00e9mit\u00e9 des mains et des pieds.<\/p><\/div><\/div>\n\t\t\t\t\t<div class=\"aa-hotspot\" style=\"top:78%;left:50%;transform:translate(-50%,-50%)\"><div class=\"aa-hotspot__dot\"><\/div><div class=\"aa-hotspot-tip aa-tip-bottom\"><div class=\"aa-hotspot-tip__title\">Membres inf\u00e9rieurs<\/div><p>Les \u0153d\u00e8mes des chevilles et des membres inf\u00e9rieurs r\u00e9sultent d\u2019une insuffisance cardiaque, d\u2019un syndrome n\u00e9phrotique, ou des deux. Des \u0153d\u00e8mes bilat\u00e9raux prenant le godet et s\u2019aggravant au fil de la journ\u00e9e sont un signe cl\u00e9 qui doit faire rechercher une amylose.<\/p><\/div><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<p class=\"aa-body-hint\">Survolez les points pour en savoir plus<\/p>\n\t\t\t<\/div>\n\t\t\t<div class=\"aa-organ-side\">\n\t\t\t\t<div class=\"aa-organ-label is-right\"><span class=\"aa-organ-label__name\">C\u0153ur<\/span><h4>Cardiomyopathie<\/h4><p>Essoufflement, gonflement des chevilles et troubles du rythme dus \u00e0 une cardiomyopathie restrictive, caus\u00e9e par l\u2019infiltration amylo\u00efde des parois des ventricules.<\/p><\/div>\n\t\t\t\t<div class=\"aa-organ-label is-right\"><span class=\"aa-organ-label__name\">Nerfs p\u00e9riph\u00e9riques<\/span><h4>Neuropathie sensitivomotrice<\/h4><p>Fourmillements, engourdissements et perte de sensibilit\u00e9 qui commencent dans les membres inf\u00e9rieurs et remontent, souvent pris \u00e0 tort pour une neuropathie diab\u00e9tique ou idiopathique.<\/p><\/div>\n\t\t\t\t<div class=\"aa-organ-label is-right\"><span class=\"aa-organ-label__name\">Membres inf\u00e9rieurs<\/span><h4>\u0152d\u00e8mes bilat\u00e9raux<\/h4><p>Un gonflement progressif des deux chevilles, souvent disproportionn\u00e9 par rapport aux atteintes cardiaque ou r\u00e9nale, qui traduit une atteinte multisyst\u00e9mique et une r\u00e9tention d\u2019eau.<\/p><\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n<\/div>\n<\/section>\n\n<section id=\"diversity\" class=\"wp-block-group aa-section aa-section--white aa-diversity is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-inner is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-diversity__left is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"aa-section-num wp-block-paragraph\">06<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">La diversit\u00e9 de l\u2019amylose<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Plus de 40 prot\u00e9ines pr\u00e9curseurs humaines sont connues pour former des d\u00e9p\u00f4ts amylo\u00efdes, chacune donnant son propre sous-type, avec une pr\u00e9sentation clinique, des organes cibles, un contexte g\u00e9n\u00e9tique et un parcours de traitement distincts.<\/p>\n\n\n\n<div class=\"wp-block-group aa-diversity__photo is-layout-flow wp-block-group-is-layout-flow\">\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"1080\" height=\"1350\" src=\"https:\/\/www.amyloidosisalliance.org\/wp-content\/uploads\/2026\/09\/Design-sans-titre.zip-1.jpg\" alt=\"\" class=\"wp-image-1188\" srcset=\"https:\/\/www.amyloidosisalliance.org\/wp-content\/uploads\/2026\/09\/Design-sans-titre.zip-1.jpg 1080w, https:\/\/www.amyloidosisalliance.org\/wp-content\/uploads\/2026\/09\/Design-sans-titre.zip-1-240x300.jpg 240w, https:\/\/www.amyloidosisalliance.org\/wp-content\/uploads\/2026\/09\/Design-sans-titre.zip-1-819x1024.jpg 819w, https:\/\/www.amyloidosisalliance.org\/wp-content\/uploads\/2026\/09\/Design-sans-titre.zip-1-768x960.jpg 768w\" sizes=\"auto, (max-width: 1080px) 100vw, 1080px\" \/><\/figure>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-acc is-layout-flow wp-block-group-is-layout-flow\">\n<details class=\"wp-block-details is-layout-flow wp-block-details-is-layout-flow\" open><summary>La prot\u00e9ine amylo\u00efde<\/summary>\n<p class=\"wp-block-paragraph\">La prot\u00e9ine pr\u00e9curseur d\u00e9finit le sous-type d\u2019amylose. Les plus fr\u00e9quentes sont\u00a0: les cha\u00eenes l\u00e9g\u00e8res d\u2019immunoglobulines (AL), la transthyr\u00e9tine (ATTR), la prot\u00e9ine amylo\u00efde A s\u00e9rique (AA), et un ensemble de variants h\u00e9r\u00e9ditaires, dont l\u2019apolipoprot\u00e9ine A-I, la gelsoline, le lysozyme et la cha\u00eene alpha du fibrinog\u00e8ne.<\/p>\n\n\n\n<ul class=\"wp-block-list aa-acc__tags\">\n<li>AL \u00b7 Cha\u00eenes l\u00e9g\u00e8res<\/li>\n\n\n\n<li>ATTR \u00b7 Transthyr\u00e9tine<\/li>\n\n\n\n<li>AA \u00b7 SAA<\/li>\n<\/ul>\n<\/details>\n\n\n\n<details class=\"wp-block-details is-layout-flow wp-block-details-is-layout-flow\"><summary>Organes touch\u00e9s<\/summary>\n<p class=\"wp-block-paragraph\">Le tropisme pour les organes d\u00e9pend du type de prot\u00e9ine amylo\u00efde. L\u2019amylose AL touche g\u00e9n\u00e9ralement le c\u0153ur, les reins, le foie, les nerfs et les tissus mous. L\u2019amylose ATTR a une affinit\u00e9 particuli\u00e8re pour le c\u0153ur et le syst\u00e8me nerveux p\u00e9riph\u00e9rique. L\u2019amylose AA cible presque exclusivement les reins. Les sous-types h\u00e9r\u00e9ditaires varient selon la mutation du g\u00e8ne.<\/p>\n\n\n\n<ul class=\"wp-block-list aa-acc__tags\">\n<li>C\u0153ur<\/li>\n\n\n\n<li>Reins<\/li>\n\n\n\n<li>Foie<\/li>\n\n\n\n<li>Nerfs<\/li>\n\n\n\n<li>Tube digestif<\/li>\n<\/ul>\n<\/details>\n\n\n\n<details class=\"wp-block-details is-layout-flow wp-block-details-is-layout-flow\"><summary>Les diff\u00e9rents types<\/summary>\n<p class=\"wp-block-paragraph\">L\u2019amylose peut \u00eatre syst\u00e9mique (atteinte \u00e9tendue des organes) ou localis\u00e9e (limit\u00e9e \u00e0 un seul tissu, comme les voies respiratoires, la vessie ou la peau). Les formes syst\u00e9miques se divisent \u00e0 leur tour en formes acquises (AL, AA) et h\u00e9r\u00e9ditaires (ATTRv, ApoA-I, gelsoline\u2026), chacune avec son mode de transmission et sa strat\u00e9gie de prise en charge.<\/p>\n\n\n\n<ul class=\"wp-block-list aa-acc__tags\">\n<li>Syst\u00e9mique<\/li>\n\n\n\n<li>Localis\u00e9e<\/li>\n\n\n\n<li>H\u00e9r\u00e9ditaire<\/li>\n\n\n\n<li>Acquise<\/li>\n<\/ul>\n<\/details>\n<\/div>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\" style=\"margin-top:36px\">\n<div class=\"wp-block-button aa-btn aa-btn--teal\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.amyloidosisalliance.org\/fr\/types-damylose\/\">D\u00e9couvrir tous les types \u2192<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n\n<section id=\"treating\" class=\"wp-block-group aa-section aa-section--cream aa-treating is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-inner is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-centered-head is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"aa-section-num wp-block-paragraph\">07<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Traiter l\u2019amylose<\/h2>\n\n\n\n<div class=\"aa-divider-dot\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">Le traitement d\u00e9pend du type d\u2019amylose. Il peut viser \u00e0 r\u00e9duire la production de la prot\u00e9ine pr\u00e9curseur, \u00e0 stabiliser la prot\u00e9ine, \u00e0 soutenir les organes touch\u00e9s et \u00e0 soulager les sympt\u00f4mes.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-treating-grid is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-treating-card is-layout-flow wp-block-group-is-layout-flow\">\n<span class=\"aa-icon-tile\"><svg aria-hidden=\"true\" focusable=\"false\" width=\"24\" height=\"24\" viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><circle cx=\"12\" cy=\"12\" r=\"10\"><\/circle><circle cx=\"12\" cy=\"12\" r=\"6\"><\/circle><circle cx=\"12\" cy=\"12\" r=\"2\"><\/circle><\/svg><\/span>\n\n\n\n<h3 class=\"wp-block-heading\">Les traitements de fond<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Des th\u00e9rapies qui ciblent la source de la substance amylo\u00efde\u00a0: chimioth\u00e9rapie pour l\u2019amylose AL (suppression des plasmocytes), stabilisateurs de la TTR et silenceurs de g\u00e8ne pour l\u2019amylose ATTR, anti-inflammatoires pour l\u2019amylose AA, dans le but d\u2019arr\u00eater la formation de nouveaux d\u00e9p\u00f4ts.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-treating-card is-layout-flow wp-block-group-is-layout-flow\">\n<span class=\"aa-icon-tile\"><svg aria-hidden=\"true\" focusable=\"false\" width=\"24\" height=\"24\" viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><path d=\"M19 14c1.49-1.46 3-3.21 3-5.5A5.5 5.5 0 0 0 16.5 3c-1.76 0-3 .5-4.5 2-1.5-1.5-2.74-2-4.5-2A5.5 5.5 0 0 0 2 8.5c0 2.29 1.51 4.04 3 5.5l7 7Z\"><\/path><path d=\"M3.22 12H9.5l.5-1 2 4.5 2-7 1.5 3.5h5.27\"><\/path><\/svg><\/span>\n\n\n\n<h3 class=\"wp-block-heading\">Les traitements de support<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">La prise en charge des complications propres \u00e0 chaque organe\u00a0: diur\u00e9tiques et antiarythmiques pour l\u2019amylose cardiaque, inhibiteurs de l\u2019enzyme de conversion pour prot\u00e9ger les reins, traitement de la douleur et kin\u00e9sith\u00e9rapie pour la neuropathie p\u00e9riph\u00e9rique.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-treating-card is-layout-flow wp-block-group-is-layout-flow\">\n<span class=\"aa-icon-tile\"><svg aria-hidden=\"true\" focusable=\"false\" width=\"24\" height=\"24\" viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><path d=\"M22 11.08V12a10 10 0 1 1-5.93-9.14\"><\/path><polyline points=\"22 4 12 14.01 9 11.01\"><\/polyline><\/svg><\/span>\n\n\n\n<h3 class=\"wp-block-heading\">Le suivi au long cours<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Une surveillance r\u00e9guli\u00e8re par des biomarqueurs (NT-proBNP, troponine, cr\u00e9atinine), de l\u2019imagerie et une \u00e9valuation de la qualit\u00e9 de vie, pour suivre la r\u00e9ponse au traitement, d\u00e9tecter t\u00f4t une rechute et adapter le traitement \u00e0 l\u2019\u00e9volution de la maladie.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n\n<section id=\"living\" class=\"wp-block-group aa-section aa-section--white aa-living is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-inner is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-living__photo is-layout-flow wp-block-group-is-layout-flow\">\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"576\" src=\"https:\/\/www.amyloidosisalliance.org\/wp-content\/uploads\/2026\/09\/doctor-talking-with-an-elderly-patient-1024x576.jpg\" alt=\"Un m&#xE9;decin parlant avec une patiente &#xE2;g&#xE9;e\" class=\"wp-image-712\" srcset=\"https:\/\/www.amyloidosisalliance.org\/wp-content\/uploads\/2026\/09\/doctor-talking-with-an-elderly-patient-1024x576.jpg 1024w, https:\/\/www.amyloidosisalliance.org\/wp-content\/uploads\/2026\/09\/doctor-talking-with-an-elderly-patient-300x169.jpg 300w, https:\/\/www.amyloidosisalliance.org\/wp-content\/uploads\/2026\/09\/doctor-talking-with-an-elderly-patient-768x432.jpg 768w, https:\/\/www.amyloidosisalliance.org\/wp-content\/uploads\/2026\/09\/doctor-talking-with-an-elderly-patient-1536x864.jpg 1536w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-group is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"aa-section-num wp-block-paragraph\">08<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Vivre avec un diagnostic rare<\/h2>\n\n\n\n<p class=\"aa-living__intro wp-block-paragraph\">Recevoir un diagnostic d\u2019amylose bouleverse une vie. La raret\u00e9 de la maladie fait que de nombreux patients se sentent isol\u00e9s, incompris et inquiets pour l\u2019avenir. Se pr\u00e9parer, cr\u00e9er des liens et acc\u00e9der aux bonnes informations font une profonde diff\u00e9rence.<\/p>\n\n\n\n<div class=\"wp-block-group aa-living-cols is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-living-col is-layout-flow wp-block-group-is-layout-flow\">\n<h4 class=\"wp-block-heading\">Conna\u00eetre votre type<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Le sous-type d\u2019amylose d\u00e9termine votre pronostic, votre traitement et le risque pour les membres de votre famille. Confirmer la prot\u00e9ine exacte en cause (par des analyses de sang, une analyse g\u00e9n\u00e9tique et le typage de la biopsie) est la premi\u00e8re \u00e9tape essentielle.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-living-col is-layout-flow wp-block-group-is-layout-flow\">\n<h4 class=\"wp-block-heading\">Pr\u00e9parer vos questions<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Utilisez notre toolkit pour les patients afin de structurer vos \u00e9changes avec votre \u00e9quipe sp\u00e9cialis\u00e9e\u00a0: quel traitement est recommand\u00e9, quels en sont les objectifs, comment l\u2019\u00e9volution sera suivie, et quels services de soutien existent pr\u00e8s de chez vous.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n\n<section class=\"wp-block-group aa-next aa-next--split is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-inner is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-next__head is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"aa-section-num wp-block-paragraph\">Continuer<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u00c0 lire ensuite<\/h2>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-next__grid is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-next-card is-layout-flow wp-block-group-is-layout-flow\">\n<h3 class=\"wp-block-heading\"><a href=\"https:\/\/www.amyloidosisalliance.org\/fr\/types-damylose\/\">Types d\u2019amylose<\/a><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Un guide d\u00e9taill\u00e9 de tous les sous-types d\u2019amylose (AL, ATTR, AA et formes h\u00e9r\u00e9ditaires plus rares), avec un tableau comparatif.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-next-card is-layout-flow wp-block-group-is-layout-flow\">\n<h3 class=\"wp-block-heading\"><a href=\"#symptoms\">Sympt\u00f4mes et diagnostic<\/a><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Comment reconna\u00eetre les signaux d\u2019alerte cliniques, et \u00e0 quoi ressemble le parcours diagnostique, du premier soup\u00e7on au typage confirm\u00e9.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-next-card is-layout-flow wp-block-group-is-layout-flow\">\n<h3 class=\"wp-block-heading\"><a href=\"#treating\">Traitements<\/a><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Le paysage th\u00e9rapeutique actuel, de la chimioth\u00e9rapie et des stabilisateurs de la TTR aux silenceurs de g\u00e8ne et aux soins de support.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n","protected":false},"excerpt":{"rendered":"<p>Accueil\u203aAmylose\u203aLa maladie \u00c0 propos de l\u2019amylose La maladie Un guide approfondi sur ce qu\u2019est l\u2019amylose, comment elle se forme, quels organes elle touche et comment elle se traite, \u00e9crit pour les patients, les familles et les professionnels de sant\u00e9. REPLI\u00c9E MAL REPLI\u00c9E FIBRILLE AMYLO\u00cfDE 01 De quoi s\u2019agit-il\u202f? 02 D\u00e9p\u00f4ts 03 Comment elle se forme [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-1423","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Qu\u2019est-ce que l\u2019amylose\u202f? 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