{"id":1421,"date":"2026-07-10T14:17:06","date_gmt":"2026-07-10T12:17:06","guid":{"rendered":"https:\/\/amyloidosisalliance.local\/amylose-al\/"},"modified":"2026-09-29T11:03:57","modified_gmt":"2026-09-29T09:03:57","slug":"amylose-al","status":"publish","type":"page","link":"https:\/\/www.amyloidosisalliance.org\/fr\/types-damylose\/amylose-al\/","title":{"rendered":"Amylose AL"},"content":{"rendered":"\n<nav class=\"wp-block-group aa-breadcrumb aa-events-hero__crumb is-layout-flow wp-block-group-is-layout-flow\" aria-label=\"Breadcrumb\">\n\t\n\t<div class=\"aa-inner\"><a href=\"\/\">Accueil<\/a><span class=\"aa-breadcrumb__sep\">\u203a<\/span><span class=\"aa-breadcrumb__label\">Amylose<\/span><span class=\"aa-breadcrumb__sep\">\u203a<\/span><a href=\"https:\/\/www.amyloidosisalliance.org\/fr\/types-damylose\/\">Types d\u2019amylose<\/a><span class=\"aa-breadcrumb__sep\">\u203a<\/span><span class=\"aa-breadcrumb__current\">Amylose AL<\/span><\/div>\n\t\n<\/nav>\n\n<section class=\"wp-block-group aa-events-hero aa-events-hero--art aa-events-hero--al is-layout-flow wp-block-group-is-layout-flow\">\n\t\n\t<div class=\"wp-block-group aa-inner is-layout-flow wp-block-group-is-layout-flow\">\n\t\t<p class=\"aa-events-hero__kicker wp-block-paragraph\">Types d\u2019amylose<\/p>\n\t\t<h1 class=\"wp-block-heading\">Amylose AL<\/h1>\n\t\t<p class=\"wp-block-paragraph\">L\u2019amylose AL est l\u2019une des principales formes d\u2019amylose syst\u00e9mique. C\u2019est une maladie acquise, due \u00e0 des plasmocytes anormaux de la moelle osseuse qui produisent des cha\u00eenes l\u00e9g\u00e8res d\u2019immunoglobulines mal repli\u00e9es. Ces cha\u00eenes l\u00e9g\u00e8res peuvent former des d\u00e9p\u00f4ts amylo\u00efdes dans diff\u00e9rents organes. Comme l\u2019atteinte des organes peut progresser rapidement, un diagnostic pr\u00e9coce et une prise en charge sp\u00e9cialis\u00e9e sont essentiels.<\/p>\n\t<\/div>\n\t\n\t\n\t<div class=\"wp-block-group aa-events-hero__art is-layout-flow wp-block-group-is-layout-flow\">\n\t\t\n\t\t<figure class=\"wp-block-image size-full\"><img decoding=\"async\" src=\"\/wp-content\/themes\/amyloidosis-alliance\/assets\/images\/disease\/al.svg\" alt=\"Sch&#xE9;ma&#xA0;: un clone de plasmocytes lib&#xE8;re des cha&#xEE;nes l&#xE9;g&#xE8;res qui se replient mal, s&#x2019;alignent et s&#x2019;empilent en une fibrille amylo&#xEF;de\"\/><\/figure>\n\t\t\n\t<\/div>\n\t\n<\/section>\n\n<nav class=\"wp-block-group aa-anchorband is-layout-flow wp-block-group-is-layout-flow\" aria-label=\"Section navigation\">\n\t\n\t<div class=\"wp-block-group aa-inner is-layout-flow wp-block-group-is-layout-flow\">\n\t\t\n\t\t<div class=\"wp-block-columns aa-anchor-cols is-layout-flex wp-container-core-columns-is-layout-b2e659ba wp-block-columns-is-layout-flex\">\n\t\t\t<div class=\"wp-block-column aa-anchor-item is-layout-flow wp-block-column-is-layout-flow\"><p class=\"num wp-block-paragraph\">01<\/p><p class=\"lbl wp-block-paragraph\"><a href=\"#what\">Qu\u2019est-ce que l\u2019AL\u202f?<\/a><\/p><\/div>\n\t\t\t<div class=\"wp-block-column aa-anchor-item is-layout-flow wp-block-column-is-layout-flow\"><p class=\"num wp-block-paragraph\">02<\/p><p class=\"lbl wp-block-paragraph\"><a href=\"#causes\">Comment elle se d\u00e9veloppe<\/a><\/p><\/div>\n\t\t\t<div class=\"wp-block-column aa-anchor-item is-layout-flow wp-block-column-is-layout-flow\"><p class=\"num wp-block-paragraph\">03<\/p><p class=\"lbl wp-block-paragraph\"><a href=\"#symptoms\">Sympt\u00f4mes<\/a><\/p><\/div>\n\t\t\t<div class=\"wp-block-column aa-anchor-item is-layout-flow wp-block-column-is-layout-flow\"><p class=\"num wp-block-paragraph\">04<\/p><p class=\"lbl wp-block-paragraph\"><a href=\"#diagnosis\">Diagnostic<\/a><\/p><\/div>\n\t\t\t<div class=\"wp-block-column aa-anchor-item is-layout-flow wp-block-column-is-layout-flow\"><p class=\"num wp-block-paragraph\">05<\/p><p class=\"lbl wp-block-paragraph\"><a href=\"#treatment\">Traitement<\/a><\/p><\/div>\n\t\t\t<div class=\"wp-block-column aa-anchor-item is-layout-flow wp-block-column-is-layout-flow\"><p class=\"num wp-block-paragraph\">06<\/p><p class=\"lbl wp-block-paragraph\"><a href=\"#follow-up\">Suivi<\/a><\/p><\/div>\n\t\t<\/div>\n\t\t\n\t<\/div>\n\t\n<\/nav>\n\n<section class=\"wp-block-group aa-section aa-section--white aa-what is-layout-flow wp-block-group-is-layout-flow\" id=\"what\">\n\t\n\t<div class=\"wp-block-group aa-inner is-layout-flow wp-block-group-is-layout-flow\">\n\t\t\n\t\t<div class=\"wp-block-group is-layout-flow wp-block-group-is-layout-flow\">\n\t\t\t<p class=\"aa-section-num wp-block-paragraph\">01<\/p>\n\t\t\t<h2 class=\"wp-block-heading\">Qu\u2019est-ce que l\u2019amylose AL\u202f?<\/h2>\n\t\t\t\n\t\t\t<div class=\"wp-block-group aa-key-idea is-layout-flow wp-block-group-is-layout-flow\">\n\t\t\t\t<p class=\"aa-key-idea__label wp-block-paragraph\">\u00c0 retenir<\/p>\n\t\t\t\t<p class=\"wp-block-paragraph\">L\u2019amylose AL ne se transmet pas dans les familles, et ce n\u2019est pas une maladie des organes qu\u2019elle ab\u00eeme. Elle commence par un petit groupe de cellules dans la moelle osseuse.<\/p>\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\n\t\t\n\t\t<div class=\"wp-block-group aa-what-cols is-layout-flow wp-block-group-is-layout-flow\">\n\t\t\t\n\t\t\t<div class=\"wp-block-group aa-what-col is-layout-flow wp-block-group-is-layout-flow\">\n\t\t\t\t<h4 class=\"wp-block-heading\">Une maladie acquise<\/h4>\n\t\t\t\t<p class=\"wp-block-paragraph\">Son nom dit ce qu\u2019elle est\u00a0: une substance <strong>A<\/strong>mylo\u00efde faite de cha\u00eenes <strong>L<\/strong>\u00e9g\u00e8res d\u2019immunoglobulines. Des fragments d\u2019anticorps monoclonaux anormaux s\u2019accumulent dans l\u2019organisme sous forme de fibrilles insolubles, et emp\u00eachent progressivement les organes de fonctionner normalement.<\/p>\n\t\t\t\t<p class=\"wp-block-paragraph\">Contrairement aux formes h\u00e9r\u00e9ditaires d\u2019amylose, l\u2019amylose AL n\u2019est pas h\u00e9r\u00e9ditaire et ne peut pas \u00eatre transmise \u00e0 vos enfants. Ces d\u00e9p\u00f4ts peuvent toucher tous les organes du corps, sauf le cerveau.<\/p>\n\t\t\t<\/div>\n\t\t\t\n\t\t\t\n\t\t\t<div class=\"wp-block-group aa-what-col is-layout-flow wp-block-group-is-layout-flow\">\n\t\t\t\t<h4 class=\"wp-block-heading\">Syst\u00e9mique ou localis\u00e9e<\/h4>\n\t\t\t\t<p class=\"wp-block-paragraph\">Dans la forme <strong>syst\u00e9mique<\/strong>, de loin la plus fr\u00e9quente et l\u2019objet de cette page, les cha\u00eenes l\u00e9g\u00e8res circulent dans le sang et se d\u00e9posent dans plusieurs organes \u00e0 la fois.<\/p>\n\t\t\t\t<p class=\"wp-block-paragraph\">Dans les formes <strong>localis\u00e9es<\/strong>, les cellules qui produisent les cha\u00eenes l\u00e9g\u00e8res se trouvent en un seul endroit et les d\u00e9p\u00f4ts restent limit\u00e9s \u00e0 un seul site\u00a0: la conjonctive, le larynx, les voies respiratoires, la vessie ou le tube digestif. Le pronostic est g\u00e9n\u00e9ralement bien meilleur. <a href=\"https:\/\/www.amyloidosisalliance.org\/fr\/types-damylose\/amylose-localisee\/\">En savoir plus sur l\u2019amylose localis\u00e9e<\/a>.<\/p>\n\t\t\t\t<p class=\"wp-block-paragraph\">Les sections ci-dessous concernent l\u2019amylose AL syst\u00e9mique.<\/p>\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\n\t<\/div>\n\t\n<\/section>\n\n<section class=\"wp-block-group aa-section aa-section--cream aa-forms is-layout-flow wp-block-group-is-layout-flow\" id=\"causes\">\n\t\n\t<div class=\"wp-block-group aa-inner is-layout-flow wp-block-group-is-layout-flow\">\n\t\t\n\t\t<div class=\"wp-block-group aa-centered-head is-layout-flow wp-block-group-is-layout-flow\">\n\t\t\t<p class=\"aa-section-num wp-block-paragraph\">02<\/p>\n\t\t\t<h2 class=\"wp-block-heading\">Comment l\u2019amylose AL se d\u00e9veloppe<\/h2>\n\t\t\t<div class=\"aa-divider-dot\"><\/div>\n\t\t\t<p class=\"wp-block-paragraph\">D\u2019une cellule normale de la moelle osseuse aux d\u00e9p\u00f4ts dans les organes, les quatre \u00e9tapes qui transforment un processus biologique ordinaire en maladie.<\/p>\n\t\t<\/div>\n\t\t\n\t\t\n\t\t<div class=\"wp-block-group aa-proc-grid is-layout-flow wp-block-group-is-layout-flow\">\n\t\t\t<div class=\"wp-block-group aa-proc-step is-layout-flow wp-block-group-is-layout-flow\"><span class=\"aa-proc-step__icon\"><svg aria-hidden=\"true\" focusable=\"false\" width=\"24\" height=\"24\" viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><circle cx=\"12\" cy=\"12\" r=\"9\"><\/circle><circle cx=\"12\" cy=\"12\" r=\"3\"><\/circle><\/svg><\/span><p class=\"aa-proc-step__num wp-block-paragraph\">\u00c9tape 01<\/p><h4 class=\"wp-block-heading\">Les plasmocytes<\/h4><p class=\"wp-block-paragraph\">Les plasmocytes et les lymphocytes B de la moelle osseuse produisent des anticorps. Chaque anticorps est form\u00e9 de deux cha\u00eenes lourdes et de deux cha\u00eenes l\u00e9g\u00e8res.<\/p><\/div>\n\t\t\t<div class=\"wp-block-group aa-proc-step is-layout-flow wp-block-group-is-layout-flow\"><span class=\"aa-proc-step__icon\"><svg aria-hidden=\"true\" focusable=\"false\" width=\"24\" height=\"24\" viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><rect x=\"9\" y=\"9\" width=\"12\" height=\"12\" rx=\"2\"><\/rect><path d=\"M5 15H4a2 2 0 0 1-2-2V4a2 2 0 0 1 2-2h9a2 2 0 0 1 2 2v1\"><\/path><\/svg><\/span><p class=\"aa-proc-step__num wp-block-paragraph\">\u00c9tape 02<\/p><h4 class=\"wp-block-heading\">Un clone appara\u00eet<\/h4><p class=\"wp-block-paragraph\">Il arrive qu\u2019une cellule devienne, en quelque sorte, immortelle. Elle se multiplie en un clone qui produit un seul et m\u00eame anticorps monoclonal, encore et encore.<\/p><\/div>\n\t\t\t<div class=\"wp-block-group aa-proc-step is-layout-flow wp-block-group-is-layout-flow\"><span class=\"aa-proc-step__icon\"><svg aria-hidden=\"true\" focusable=\"false\" width=\"24\" height=\"24\" viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><polyline points=\"16 3 21 3 21 8\"><\/polyline><line x1=\"4\" y1=\"20\" x2=\"21\" y2=\"3\"><\/line><polyline points=\"21 16 21 21 16 21\"><\/polyline><line x1=\"15\" y1=\"15\" x2=\"21\" y2=\"21\"><\/line><line x1=\"4\" y1=\"4\" x2=\"9\" y2=\"9\"><\/line><\/svg><\/span><p class=\"aa-proc-step__num wp-block-paragraph\">\u00c9tape 03<\/p><h4 class=\"wp-block-heading\">Les cha\u00eenes l\u00e9g\u00e8res se replient mal<\/h4><p class=\"wp-block-paragraph\">Dans environ 1 % des cas, ces cha\u00eenes l\u00e9g\u00e8res libres sont instables. Elles s\u2019empilent en fibrilles amylo\u00efdes que l\u2019organisme ne sait pas \u00e9liminer.<\/p><\/div>\n\t\t\t<div class=\"wp-block-group aa-proc-step is-layout-flow wp-block-group-is-layout-flow\"><span class=\"aa-proc-step__icon\"><svg aria-hidden=\"true\" focusable=\"false\" width=\"24\" height=\"24\" viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><path d=\"M10.29 3.86L1.82 18a2 2 0 0 0 1.71 3h16.94a2 2 0 0 0 1.71-3L13.71 3.86a2 2 0 0 0-3.42 0z\"><\/path><line x1=\"12\" y1=\"9\" x2=\"12\" y2=\"13\"><\/line><line x1=\"12\" y1=\"17\" x2=\"12.01\" y2=\"17\"><\/line><\/svg><\/span><p class=\"aa-proc-step__num wp-block-paragraph\">\u00c9tape 04<\/p><h4 class=\"wp-block-heading\">D\u00e9p\u00f4ts dans les organes<\/h4><p class=\"wp-block-paragraph\">Les fibrilles se d\u00e9posent dans les tissus, les rigidifient et perturbent leur fonctionnement. Les organes touch\u00e9s, et l\u2019intensit\u00e9 de leur atteinte, d\u00e9terminent tout le tableau clinique.<\/p><\/div>\n\t\t<\/div>\n\t\t\n\t\t\n\t\t<div class=\"wp-block-group aa-tp-facts is-layout-flow wp-block-group-is-layout-flow\">\n\t\t\t<div class=\"wp-block-group aa-tp-fact aa-tp-fact--text is-layout-flow wp-block-group-is-layout-flow\"><p class=\"aa-tp-fact__lbl wp-block-paragraph\">Incidence estim\u00e9e\u00a0: environ <strong>8 \u00e0 12<\/strong> nouveaux cas par million d\u2019habitants et par an. Les donn\u00e9es mondiales fiables sont limit\u00e9es, et un sous-diagnostic est probable.<\/p><\/div>\n\t\t\t<div class=\"wp-block-group aa-tp-fact aa-tp-fact--text is-layout-flow wp-block-group-is-layout-flow\"><p class=\"aa-tp-fact__lbl wp-block-paragraph\">Diagnostiqu\u00e9e le plus souvent chez des personnes \u00e2g\u00e9es, g\u00e9n\u00e9ralement entre <strong>60<\/strong> et <strong>70<\/strong> ans.<\/p><\/div>\n\t\t\t<div class=\"wp-block-group aa-tp-fact is-layout-flow wp-block-group-is-layout-flow\"><p class=\"aa-tp-fact__num wp-block-paragraph\">~1 %<\/p><p class=\"aa-tp-fact__lbl wp-block-paragraph\">des cha\u00eenes l\u00e9g\u00e8res monoclonales forment des fibrilles amylo\u00efdes<\/p><\/div>\n\t\t<\/div>\n\t\t\n\t\t\n\t\t<div class=\"wp-block-group aa-acc is-layout-flow wp-block-group-is-layout-flow\">\n\t\t\t<h3 class=\"wp-block-heading\">Des maladies apparent\u00e9es dont vous avez peut-\u00eatre entendu parler<\/h3>\n\t\t\t\n\t\t\t<details class=\"wp-block-details is-layout-flow wp-block-details-is-layout-flow\"><summary>MGUS, gammapathie monoclonale de signification ind\u00e9termin\u00e9e<\/summary>\n\t\t\t<p class=\"wp-block-paragraph\">Une immunoglobuline monoclonale est pr\u00e9sente, mais elle concerne moins de 10 % des cellules de la moelle osseuse. La MGUS devient plus fr\u00e9quente avec l\u2019\u00e2ge\u00a0: on la retrouve chez environ 5 % des personnes \u00e0 60 ans, et jusqu\u2019\u00e0 10 % des personnes de plus de 80 ans. La plupart des personnes atteintes de MGUS ne d\u00e9velopperont jamais d\u2019amylose.<\/p>\n\t\t\t<ul class=\"wp-block-list aa-acc__tags\"><li>&lt; 10 % des cellules<\/li><li>5 % \u00e0 60 ans<\/li><li>10 % apr\u00e8s 80 ans<\/li><\/ul>\n\t\t\t<\/details>\n\t\t\t\n\t\t\t\n\t\t\t<details class=\"wp-block-details is-layout-flow wp-block-details-is-layout-flow\"><summary>My\u00e9lome<\/summary>\n\t\t\t<p class=\"wp-block-paragraph\">Le my\u00e9lome concerne plus de 10 % des cellules de la moelle osseuse. Lorsqu\u2019un my\u00e9lome est d\u00e9couvert en m\u00eame temps qu\u2019une amylose AL, il est g\u00e9n\u00e9ralement indolent, d\u2019\u00e9volution lente. Les deux maladies viennent de la m\u00eame famille de cellules, c\u2019est pourquoi l\u2019amylose AL est trait\u00e9e par des protocoles initialement con\u00e7us pour le my\u00e9lome.<\/p>\n\t\t\t<ul class=\"wp-block-list aa-acc__tags\"><li>&gt; 10 % des cellules<\/li><li>G\u00e9n\u00e9ralement indolent<\/li><li>Des traitements communs<\/li><\/ul>\n\t\t\t<\/details>\n\t\t\t\n\t\t<\/div>\n\t\t\n\t<\/div>\n\t\n<\/section>\n\n<section class=\"wp-block-group aa-section aa-section--white aa-tp-symptoms is-layout-flow wp-block-group-is-layout-flow\" id=\"symptoms\">\n\t\n\t<div class=\"wp-block-group aa-inner is-layout-flow wp-block-group-is-layout-flow\">\n\t\t\n\t\t<div class=\"wp-block-group aa-centered-head is-layout-flow wp-block-group-is-layout-flow\">\n\t\t\t<p class=\"aa-section-num wp-block-paragraph\">03<\/p>\n\t\t\t<h2 class=\"wp-block-heading\">Sympt\u00f4mes<\/h2>\n\t\t\t<div class=\"aa-divider-dot\"><\/div>\n\t\t\t<p class=\"wp-block-paragraph\">Les sympt\u00f4mes d\u00e9pendent enti\u00e8rement des organes que les fibrilles ont atteints. Comme chaque sympt\u00f4me est banal pris isol\u00e9ment, l\u2019amylose AL est facilement confondue avec une maladie plus ordinaire, ce qui explique que le diagnostic soit si souvent retard\u00e9.<\/p>\n\t\t<\/div>\n\t\t\n\t\t\n\t\t<div class=\"wp-block-group aa-tp-organs aa-tp-organs--major is-layout-flow wp-block-group-is-layout-flow\">\n\t\t\t<div class=\"wp-block-group aa-tp-organ is-layout-flow wp-block-group-is-layout-flow\"><p class=\"aa-tp-organ__freq wp-block-paragraph\">&gt; 2 sur 3<\/p><h3 class=\"wp-block-heading\">Reins<\/h3><p class=\"aa-tp-organ__tag wp-block-paragraph\">Les plus souvent touch\u00e9s<\/p><p class=\"wp-block-paragraph\">La substance amylo\u00efde ab\u00eeme le filtre glom\u00e9rulaire et laisse l\u2019albumine s\u2019\u00e9chapper dans les urines. Cela provoque un gonflement des jambes ou des \u0153d\u00e8mes plus \u00e9tendus, et une baisse de la fonction r\u00e9nale qui peut finir par n\u00e9cessiter une dialyse.<\/p><\/div>\n\t\t\t<div class=\"wp-block-group aa-tp-organ is-layout-flow wp-block-group-is-layout-flow\"><p class=\"aa-tp-organ__freq wp-block-paragraph\">~60 %<\/p><h3 class=\"wp-block-heading\">C\u0153ur<\/h3><p class=\"aa-tp-organ__tag wp-block-paragraph\">L\u2019atteinte la plus grave<\/p><p class=\"wp-block-paragraph\">Le muscle cardiaque s\u2019\u00e9paissit et perd sa capacit\u00e9 \u00e0 se rel\u00e2cher et \u00e0 se remplir\u00a0: c\u2019est une cardiomyopathie restrictive. Elle entra\u00eene fatigue et essoufflement, d\u2019abord \u00e0 l\u2019effort puis au repos. Des troubles du rythme peuvent n\u00e9cessiter un pacemaker.<\/p><\/div>\n\t\t\t<div class=\"wp-block-group aa-tp-organ is-layout-flow wp-block-group-is-layout-flow\"><p class=\"aa-tp-organ__freq wp-block-paragraph\">~20 %<\/p><h3 class=\"wp-block-heading\">Nerfs<\/h3><p class=\"aa-tp-organ__tag wp-block-paragraph\">P\u00e9riph\u00e9riques et autonomes<\/p><p class=\"wp-block-paragraph\">Des sensations anormales commencent dans les pieds et remontent vers les jambes, les cuisses et les mains. Lorsque les nerfs autonomes sont touch\u00e9s, ils provoquent des troubles digestifs et une chute de la tension en position debout, avec malaises et chutes.<\/p><\/div>\n\t\t<\/div>\n\t\t\n\t\t\n\t\t<div class=\"wp-block-group aa-tp-organs aa-tp-organs--minor is-layout-flow wp-block-group-is-layout-flow\">\n\t\t\t<div class=\"wp-block-group aa-tp-organ is-layout-flow wp-block-group-is-layout-flow\"><h3 class=\"wp-block-heading\">Tube digestif<\/h3><p class=\"wp-block-paragraph\">Diarrh\u00e9e et constipation, souvent en alternance, et parfois des saignements. Les d\u00e9p\u00f4ts dans la langue la font grossir et peuvent modifier le go\u00fbt.<\/p><\/div>\n\t\t\t<div class=\"wp-block-group aa-tp-organ is-layout-flow wp-block-group-is-layout-flow\"><h3 class=\"wp-block-heading\">Peau<\/h3><p class=\"wp-block-paragraph\">La substance amylo\u00efde fragilise les petits vaisseaux de la peau, qui saigne et marque facilement. Les ecchymoses autour des yeux sont un signe particuli\u00e8rement \u00e9vocateur.<\/p><\/div>\n\t\t<\/div>\n\t\t\n\t\t\n\t\t<div class=\"wp-block-group aa-tp-flags is-layout-flow wp-block-group-is-layout-flow\">\n\t\t\t\n\t\t\t<div class=\"wp-block-group aa-tp-flags__photo is-layout-flow wp-block-group-is-layout-flow\">\n\t\t\t\t<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"683\" height=\"1024\" src=\"https:\/\/www.amyloidosisalliance.org\/wp-content\/uploads\/2026\/09\/anatomical-model-of-a-human-heart-683x1024.jpg\" alt=\"Mod&#xE8;le anatomique d&#x2019;un c&#x153;ur humain\" class=\"wp-image-698\" srcset=\"https:\/\/www.amyloidosisalliance.org\/wp-content\/uploads\/2026\/09\/anatomical-model-of-a-human-heart-683x1024.jpg 683w, https:\/\/www.amyloidosisalliance.org\/wp-content\/uploads\/2026\/09\/anatomical-model-of-a-human-heart-200x300.jpg 200w, https:\/\/www.amyloidosisalliance.org\/wp-content\/uploads\/2026\/09\/anatomical-model-of-a-human-heart-768x1152.jpg 768w, https:\/\/www.amyloidosisalliance.org\/wp-content\/uploads\/2026\/09\/anatomical-model-of-a-human-heart-1024x1536.jpg 1024w, https:\/\/www.amyloidosisalliance.org\/wp-content\/uploads\/2026\/09\/anatomical-model-of-a-human-heart-1365x2048.jpg 1365w\" sizes=\"auto, (max-width: 683px) 100vw, 683px\" \/><\/figure>\n\t\t\t<\/div>\n\t\t\t\n\t\t\t\n\t\t\t<div class=\"wp-block-group aa-tp-flags__body is-layout-flow wp-block-group-is-layout-flow\">\n\t\t\t\t<h3 class=\"wp-block-heading\">Quand consulter<\/h3>\n\t\t\t\t<p class=\"wp-block-paragraph\">Aucun des signes ci-dessous n\u2019oriente \u00e0 lui seul vers une amylose AL. Plusieurs d\u2019entre eux ensemble, surtout s\u2019ils sont r\u00e9cents et inexpliqu\u00e9s, m\u00e9ritent d\u2019\u00eatre signal\u00e9s \u00e0 un m\u00e9decin.<\/p>\n\t\t\t\t\n\t\t\t\t<ul class=\"wp-block-list aa-tp-flags__list\">\n\t\t\t\t\t<li>Un gonflement des chevilles et des jambes<\/li>\n\t\t\t\t\t<li>Une fatigue que le repos ne soulage pas<\/li>\n\t\t\t\t\t<li>Un essoufflement au moindre effort<\/li>\n\t\t\t\t\t<li>Engourdissements, fourmillements ou douleurs dans les mains et les pieds<\/li>\n\t\t\t\t\t<li>Diarrh\u00e9e alternant avec une constipation<\/li>\n\t\t\t\t\t<li>Une perte de poids inexpliqu\u00e9e<\/li>\n\t\t\t\t\t<li>Une langue qui grossit<\/li>\n\t\t\t\t\t<li>Des ecchymoses, en particulier autour des yeux<\/li>\n\t\t\t\t\t<li>Un rythme cardiaque irr\u00e9gulier<\/li>\n\t\t\t\t<\/ul>\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t<div class=\"wp-block-group aa-tp-alert is-layout-flow wp-block-group-is-layout-flow\">\n\t\t\t\t\t<p class=\"wp-block-paragraph\">L\u2019amylose AL peut rapidement mettre la vie en danger. La rep\u00e9rer t\u00f4t est crucial.<\/p>\n\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\n\t<\/div>\n\t\n<\/section>\n\n<section class=\"wp-block-group aa-section aa-section--cream aa-tp-dx is-layout-flow wp-block-group-is-layout-flow\" id=\"diagnosis\">\n\t\n\t<div class=\"wp-block-group aa-inner is-layout-flow wp-block-group-is-layout-flow\">\n\t\t\n\t\t<div class=\"wp-block-group aa-tp-dx__body is-layout-flow wp-block-group-is-layout-flow\">\n\t\t\t<p class=\"aa-section-num wp-block-paragraph\">04<\/p>\n\t\t\t<h2 class=\"wp-block-heading\">Comment l\u2019amylose AL est diagnostiqu\u00e9e<\/h2>\n\t\t\t<p class=\"aa-tp-dx__intro wp-block-paragraph\">Poser le diagnostic, c\u2019est r\u00e9pondre \u00e0 trois questions distinctes\u00a0: y a-t-il de la substance amylo\u00efde, de quel type est-elle, et quels d\u00e9g\u00e2ts a-t-elle d\u00e9j\u00e0 caus\u00e9s\u202f? Certains de ces examens peuvent impressionner. La plupart sont rapides, et votre \u00e9quipe vous expliquera chacun d\u2019eux.<\/p>\n\t\t\t\n\t\t\t<div class=\"wp-block-group aa-tp-dx__steps is-layout-flow wp-block-group-is-layout-flow\">\n\t\t\t\t<div class=\"wp-block-group aa-tp-dx__step is-layout-flow wp-block-group-is-layout-flow\"><p class=\"aa-tp-dx__step-num wp-block-paragraph\">01<\/p><h4 class=\"wp-block-heading\">Confirmer la substance amylo\u00efde<\/h4><p class=\"wp-block-paragraph\">Le diagnostic n\u00e9cessite toujours une biopsie de tissu. Color\u00e9s au rouge Congo, les d\u00e9p\u00f4ts amylo\u00efdes se r\u00e9v\u00e8lent en lumi\u00e8re polaris\u00e9e.<\/p><\/div>\n\t\t\t\t<div class=\"wp-block-group aa-tp-dx__step is-layout-flow wp-block-group-is-layout-flow\"><p class=\"aa-tp-dx__step-num wp-block-paragraph\">02<\/p><h4 class=\"wp-block-heading\">Typer la substance amylo\u00efde<\/h4><p class=\"wp-block-paragraph\">Les d\u00e9p\u00f4ts sont ensuite typ\u00e9s pour distinguer l\u2019amylose AL des autres formes, en particulier des formes h\u00e9r\u00e9ditaires. Cette \u00e9tape est essentielle\u00a0: les traitements n\u2019ont rien en commun.<\/p><\/div>\n\t\t\t\t<div class=\"wp-block-group aa-tp-dx__step is-layout-flow wp-block-group-is-layout-flow\"><p class=\"aa-tp-dx__step-num wp-block-paragraph\">03<\/p><h4 class=\"wp-block-heading\">Caract\u00e9riser l\u2019atteinte de la moelle osseuse<\/h4><p class=\"wp-block-paragraph\">Un pr\u00e9l\u00e8vement de moelle osseuse identifie les cellules qui produisent l\u2019anticorps anormal, tandis que des analyses de sang et d\u2019urine mesurent les cha\u00eenes l\u00e9g\u00e8res libres elles-m\u00eames.<\/p><\/div>\n\t\t\t\t<div class=\"wp-block-group aa-tp-dx__step is-layout-flow wp-block-group-is-layout-flow\"><p class=\"aa-tp-dx__step-num wp-block-paragraph\">04<\/p><h4 class=\"wp-block-heading\">\u00c9valuer l\u2019atteinte des organes<\/h4><p class=\"wp-block-paragraph\"><strong>C\u0153ur\u00a0:<\/strong> \u00e9chocardiographie, IRM cardiaque si elle est indiqu\u00e9e, biomarqueurs (BNP, NT-proBNP, troponine), ECG et Holter des 24 heures si l\u2019\u00e9tat clinique le justifie.<br\/><strong>Reins et foie\u00a0:<\/strong> cr\u00e9atinine, albumine, prot\u00e9inurie et bilan h\u00e9patique.<br\/><strong>Imagerie\u00a0:<\/strong> \u00e9chographie ou scanner abdominal.<\/p><\/div>\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\n\t\t\n\t\t<div class=\"wp-block-group aa-tp-dx__photo is-layout-flow wp-block-group-is-layout-flow\">\n\t\t\t<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"683\" src=\"https:\/\/www.amyloidosisalliance.org\/wp-content\/uploads\/2026\/09\/laboratory-microscope-1024x683.jpg\" alt=\"Microscope de laboratoire\" class=\"wp-image-708\" srcset=\"https:\/\/www.amyloidosisalliance.org\/wp-content\/uploads\/2026\/09\/laboratory-microscope-1024x683.jpg 1024w, https:\/\/www.amyloidosisalliance.org\/wp-content\/uploads\/2026\/09\/laboratory-microscope-300x200.jpg 300w, https:\/\/www.amyloidosisalliance.org\/wp-content\/uploads\/2026\/09\/laboratory-microscope-768x512.jpg 768w, https:\/\/www.amyloidosisalliance.org\/wp-content\/uploads\/2026\/09\/laboratory-microscope-1536x1024.jpg 1536w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\t\t<\/div>\n\t\t\n\t<\/div>\n\t\n<\/section>\n\n<section class=\"wp-block-group aa-section aa-section--white aa-treating is-layout-flow wp-block-group-is-layout-flow\" id=\"treatment\">\n\t\n\t<div class=\"wp-block-group aa-inner is-layout-flow wp-block-group-is-layout-flow\">\n\t\t\n\t\t<div class=\"wp-block-group aa-centered-head is-layout-flow wp-block-group-is-layout-flow\">\n\t\t\t<p class=\"aa-section-num wp-block-paragraph\">05<\/p>\n\t\t\t<h2 class=\"wp-block-heading\">Traitement<\/h2>\n\t\t\t<div class=\"aa-divider-dot\"><\/div>\n\t\t\t<p class=\"wp-block-paragraph\">Le traitement n\u2019\u00e9limine pas les d\u00e9p\u00f4ts. Il coupe l\u2019approvisionnement, en d\u00e9truisant les cellules qui produisent les cha\u00eenes l\u00e9g\u00e8res toxiques, pour que l\u2019organisme puisse commencer \u00e0 \u00e9liminer ce qui s\u2019est accumul\u00e9.<\/p>\n\t\t<\/div>\n\t\t\n\t\t\n\t\t<div class=\"wp-block-group aa-tp-treat-lead is-layout-flow wp-block-group-is-layout-flow\">\n\t\t\t\n\t\t\t<div class=\"wp-block-group aa-tp-treat-lead__photo is-layout-flow wp-block-group-is-layout-flow\">\n\t\t\t\t<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"684\" src=\"https:\/\/www.amyloidosisalliance.org\/wp-content\/uploads\/2026\/09\/orange-and-white-capsules-spilling-from-a-container-1024x684.jpg\" alt=\"Des g&#xE9;lules orange et blanches qui s&#x2019;&#xE9;chappent d&#x2019;un flacon\" class=\"wp-image-709\" srcset=\"https:\/\/www.amyloidosisalliance.org\/wp-content\/uploads\/2026\/09\/orange-and-white-capsules-spilling-from-a-container-1024x684.jpg 1024w, https:\/\/www.amyloidosisalliance.org\/wp-content\/uploads\/2026\/09\/orange-and-white-capsules-spilling-from-a-container-300x200.jpg 300w, https:\/\/www.amyloidosisalliance.org\/wp-content\/uploads\/2026\/09\/orange-and-white-capsules-spilling-from-a-container-768x513.jpg 768w, https:\/\/www.amyloidosisalliance.org\/wp-content\/uploads\/2026\/09\/orange-and-white-capsules-spilling-from-a-container-1536x1025.jpg 1536w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\t\t\t<\/div>\n\t\t\t\n\t\t\t\n\t\t\t<div class=\"wp-block-group aa-tp-treat-lead__body is-layout-flow wp-block-group-is-layout-flow\">\n\t\t\t\t<p class=\"wp-block-paragraph\">Le traitement cible le clone anormal de plasmocytes ou de lymphocytes B responsable de la production des cha\u00eenes l\u00e9g\u00e8res amylo\u00efdog\u00e8nes. Lorsque la maladie sous-jacente est un clone de lymphocytes B, le traitement vise ce clone et diff\u00e8re de l\u2019approche habituelle dirig\u00e9e contre les plasmocytes. Le protocole et son intensit\u00e9 sont adapt\u00e9s \u00e0 l\u2019atteinte des organes, \u00e0 l\u2019\u00e9tat de sant\u00e9 g\u00e9n\u00e9ral et \u00e0 la tol\u00e9rance au traitement. La r\u00e9ponse est suivie par des analyses de sang, tandis que la r\u00e9cup\u00e9ration ou la progression de l\u2019atteinte des organes est \u00e9valu\u00e9e s\u00e9par\u00e9ment dans le temps.<\/p>\n\t\t\t\t<p class=\"wp-block-paragraph\">Les d\u00e9p\u00f4ts amylo\u00efdes peuvent r\u00e9gresser lentement une fois la production de cha\u00eenes l\u00e9g\u00e8res anormales contr\u00f4l\u00e9e. C\u2019est pourquoi l\u2019am\u00e9lioration des organes peut survenir plus tard que la r\u00e9ponse h\u00e9matologique. Une excellente r\u00e9ponse h\u00e9matologique ne conduit pas toujours \u00e0 une r\u00e9ponse des organes. La r\u00e9cup\u00e9ration varie selon l\u2019organe touch\u00e9 et l\u2019\u00e9tendue des l\u00e9sions existantes.<\/p>\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\n\t\t\n\t\t<div class=\"wp-block-group aa-treating-grid is-layout-flow wp-block-group-is-layout-flow\">\n\t\t\t<div class=\"wp-block-group aa-treating-card is-layout-flow wp-block-group-is-layout-flow\"><span class=\"aa-icon-tile\"><svg aria-hidden=\"true\" focusable=\"false\" width=\"24\" height=\"24\" viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><circle cx=\"12\" cy=\"12\" r=\"10\"><\/circle><circle cx=\"12\" cy=\"12\" r=\"6\"><\/circle><circle cx=\"12\" cy=\"12\" r=\"2\"><\/circle><\/svg><\/span><h3 class=\"wp-block-heading\">Premi\u00e8re ligne\u00a0: Dara-VCd<\/h3><p class=\"wp-block-paragraph\">L\u2019association la plus utilis\u00e9e aujourd\u2019hui\u00a0: un anticorps monoclonal ajout\u00e9 \u00e0 un inhibiteur du prot\u00e9asome, un agent alkylant et un cortico\u00efde.<\/p><\/div>\n\t\t\t<div class=\"wp-block-group aa-treating-card is-layout-flow wp-block-group-is-layout-flow\"><span class=\"aa-icon-tile\"><svg aria-hidden=\"true\" focusable=\"false\" width=\"24\" height=\"24\" viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><path d=\"M10.5 20.5 3.5 13.5a5 5 0 0 1 7-7l7 7a5 5 0 0 1-7 7Z\"><\/path><path d=\"m8.5 8.5 7 7\"><\/path><\/svg><\/span><h3 class=\"wp-block-heading\">Inhibiteurs du prot\u00e9asome<\/h3><p class=\"wp-block-paragraph\">Ces agents poussent les plasmocytes anormaux vers la mort cellulaire programm\u00e9e. Utilis\u00e9s depuis bien plus de dix ans, ils r\u00e9duisent fortement leur nombre.<\/p><\/div>\n\t\t\t<div class=\"wp-block-group aa-treating-card is-layout-flow wp-block-group-is-layout-flow\"><span class=\"aa-icon-tile\"><svg aria-hidden=\"true\" focusable=\"false\" width=\"24\" height=\"24\" viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><path d=\"M12 22s8-4 8-10V5l-8-3-8 3v7c0 6 8 10 8 10z\"><\/path><\/svg><\/span><h3 class=\"wp-block-heading\">Immunomodulateurs<\/h3><p class=\"wp-block-paragraph\">Ces agents ralentissent la multiplication des cellules anormales plut\u00f4t que de les tuer directement.<\/p><\/div>\n\t\t\t<div class=\"wp-block-group aa-treating-card is-layout-flow wp-block-group-is-layout-flow\"><span class=\"aa-icon-tile\"><svg aria-hidden=\"true\" focusable=\"false\" width=\"24\" height=\"24\" viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><path d=\"M12 2v20\"><\/path><path d=\"M5 5l14 14\"><\/path><path d=\"M19 5 5 19\"><\/path><\/svg><\/span><h3 class=\"wp-block-heading\">Anticorps monoclonaux<\/h3><p class=\"wp-block-paragraph\">Ils reconnaissent les plasmocytes qui produisent les cha\u00eenes l\u00e9g\u00e8res nocives et les d\u00e9signent pour destruction.<\/p><\/div>\n\t\t\t<div class=\"wp-block-group aa-treating-card is-layout-flow wp-block-group-is-layout-flow\"><span class=\"aa-icon-tile\"><svg aria-hidden=\"true\" focusable=\"false\" width=\"24\" height=\"24\" viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><path d=\"M12 22a7 7 0 0 0 7-7c0-2-1-3.9-3-5.5s-3.5-4-4-6.5c-.5 2.5-2 4.9-4 6.5S5 13 5 15a7 7 0 0 0 7 7z\"><\/path><\/svg><\/span><h3 class=\"wp-block-heading\">Cortico\u00efdes<\/h3><p class=\"wp-block-paragraph\">Les cortico\u00efdes ne sont pas donn\u00e9s seuls. Ils sont toujours associ\u00e9s \u00e0 l\u2019un des agents ci-dessus, dont ils amplifient l\u2019effet.<\/p><\/div>\n\t\t\t<div class=\"wp-block-group aa-treating-card is-layout-flow wp-block-group-is-layout-flow\"><span class=\"aa-icon-tile\"><svg aria-hidden=\"true\" focusable=\"false\" width=\"24\" height=\"24\" viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><path d=\"M12 3l2.5 6.5L21 12l-6.5 2.5L12 21l-2.5-6.5L3 12l6.5-2.5z\"><\/path><\/svg><\/span><h3 class=\"wp-block-heading\">Th\u00e9rapies \u00e9mergentes<\/h3><p class=\"wp-block-paragraph\">Des th\u00e9rapies cibl\u00e9es et des anticorps bisp\u00e9cifiques, une classe plus r\u00e9cente, sont utilis\u00e9s seuls ou en association. Parmi les approches \u00e9mergentes figurent aussi des th\u00e9rapies visant \u00e0 \u00e9liminer les d\u00e9p\u00f4ts amylo\u00efdes ou \u00e0 stabiliser leur formation. Les essais se poursuivent\u00a0: demandez \u00e0 votre \u00e9quipe lesquels vous sont ouverts.<\/p><\/div>\n\t\t<\/div>\n\t\t\n\t\t\n\t\t<div class=\"wp-block-group aa-tp-asct is-layout-flow wp-block-group-is-layout-flow\">\n\t\t\t<h3 class=\"wp-block-heading\">Autogreffe de cellules souches<\/h3>\n\t\t\t<p class=\"wp-block-paragraph\">Chez certains patients, une chimioth\u00e9rapie \u00e0 haute dose suivie d\u2019une autogreffe de cellules souches peut \u00eatre envisag\u00e9e dans un centre sp\u00e9cialis\u00e9 exp\u00e9riment\u00e9. L\u2019\u00e9ligibilit\u00e9 d\u00e9pend de l\u2019atteinte des organes, de l\u2019\u00e9tat g\u00e9n\u00e9ral et du risque li\u00e9 au traitement. Cette approche ne convient pas \u00e0 la plupart des patients.<\/p>\n\t\t<\/div>\n\t\t\n\t\t\n\t\t<div class=\"wp-block-group aa-tp-support is-layout-flow wp-block-group-is-layout-flow\">\n\t\t\t<h4 class=\"wp-block-heading\">Les soins de support en parall\u00e8le<\/h4>\n\t\t\t<p class=\"wp-block-paragraph\">Des soins de support accompagnent le traitement de la maladie plasmocytaire. Ils visent \u00e0 prendre en charge les sympt\u00f4mes et les complications touchant le c\u0153ur, les reins, les nerfs et les autres organes. Les mesures employ\u00e9es d\u00e9pendent des organes touch\u00e9s, de la gravit\u00e9 de la maladie et des ressources disponibles localement.<\/p>\n\t\t\t\n\t\t\t<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n\t\t\t\t<div class=\"wp-block-button aa-btn aa-btn--teal\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.amyloidosisalliance.org\/clinical-trials\/\">Essais cliniques \u2192<\/a><\/div>\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\n\t<\/div>\n\t\n<\/section>\n\n<section class=\"wp-block-group aa-section aa-section--forest aa-tp-outlook is-layout-flow wp-block-group-is-layout-flow\" id=\"follow-up\">\n\t\n\t<div class=\"wp-block-group aa-inner is-layout-flow wp-block-group-is-layout-flow\">\n\t\t\n\t\t<div class=\"wp-block-group aa-tp-outlook__photo is-layout-flow wp-block-group-is-layout-flow\">\n\t\t\t<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"699\" src=\"https:\/\/www.amyloidosisalliance.org\/wp-content\/uploads\/2026\/09\/a-nurse-measuring-a-patients-blood-pressure-1024x699.jpg\" alt=\"Une infirmi&#xE8;re mesurant la tension art&#xE9;rielle d&#x2019;un patient\" class=\"wp-image-710\" srcset=\"https:\/\/www.amyloidosisalliance.org\/wp-content\/uploads\/2026\/09\/a-nurse-measuring-a-patients-blood-pressure-1024x699.jpg 1024w, https:\/\/www.amyloidosisalliance.org\/wp-content\/uploads\/2026\/09\/a-nurse-measuring-a-patients-blood-pressure-300x205.jpg 300w, https:\/\/www.amyloidosisalliance.org\/wp-content\/uploads\/2026\/09\/a-nurse-measuring-a-patients-blood-pressure-768x524.jpg 768w, https:\/\/www.amyloidosisalliance.org\/wp-content\/uploads\/2026\/09\/a-nurse-measuring-a-patients-blood-pressure-1536x1048.jpg 1536w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\t\t<\/div>\n\t\t\n\t\t\n\t\t<div class=\"wp-block-group aa-tp-outlook__body is-layout-flow wp-block-group-is-layout-flow\">\n\t\t\t<p class=\"aa-section-num wp-block-paragraph\">06<\/p>\n\t\t\t<h2 class=\"wp-block-heading\">Suivi et pronostic<\/h2>\n\t\t\t<h4 class=\"wp-block-heading\">Surveillance<\/h4>\n\t\t\t<p class=\"wp-block-paragraph\">Pendant et apr\u00e8s le traitement, des analyses de sang permettent de surveiller les cha\u00eenes l\u00e9g\u00e8res anormales, la tol\u00e9rance du traitement et la fonction des organes. La fr\u00e9quence du suivi et la d\u00e9cision de reprendre un traitement d\u00e9pendent de chaque situation et doivent \u00eatre d\u00e9termin\u00e9es par l\u2019\u00e9quipe sp\u00e9cialis\u00e9e.<\/p>\n\t\t\t<h4 class=\"wp-block-heading\">Pronostic<\/h4>\n\t\t\t<p class=\"wp-block-paragraph\">Le pronostic varie beaucoup et d\u00e9pend fortement de l\u2019\u00e9tendue de l\u2019atteinte du c\u0153ur et des autres organes au moment du diagnostic, de la profondeur et de la rapidit\u00e9 de la r\u00e9ponse h\u00e9matologique, et de l\u2019\u00e9tat de sant\u00e9 g\u00e9n\u00e9ral. Les r\u00e9sultats se sont nettement am\u00e9lior\u00e9s gr\u00e2ce \u00e0 un diagnostic plus pr\u00e9coce, \u00e0 des traitements plus efficaces dirig\u00e9s contre les plasmocytes et \u00e0 des soins de support sp\u00e9cialis\u00e9s. Une atteinte cardiaque avanc\u00e9e reste toutefois un facteur de risque majeur.<\/p>\n\t\t\t<p class=\"aa-tp-outlook__closing wp-block-paragraph\">De tout ce qui influence l\u2019\u00e9volution, le d\u00e9lai avant le diagnostic est ce que nous pouvons encore changer.<\/p>\n\t\t<\/div>\n\t\t\n\t<\/div>\n\t\n<\/section>\n\n<section class=\"wp-block-group aa-section aa-section--white aa-tp-faq is-layout-flow wp-block-group-is-layout-flow\">\n\t\n\t<div class=\"wp-block-group aa-inner is-layout-flow wp-block-group-is-layout-flow\">\n\t\t\n\t\t<div class=\"wp-block-group aa-centered-head is-layout-flow wp-block-group-is-layout-flow\">\n\t\t\t<p class=\"aa-section-num wp-block-paragraph\">FAQ<\/p>\n\t\t\t<h2 class=\"wp-block-heading\">Questions fr\u00e9quentes<\/h2>\n\t\t\t<div class=\"aa-divider-dot\"><\/div>\n\t\t<\/div>\n\t\t\n\t\t\n\t\t<div class=\"wp-block-group aa-acc is-layout-flow wp-block-group-is-layout-flow\">\n\t\t\t\n\t\t\t<details class=\"wp-block-details is-layout-flow wp-block-details-is-layout-flow\"><summary>L\u2019amylose AL est-elle h\u00e9r\u00e9ditaire\u202f?<\/summary>\n\t\t\t<p class=\"wp-block-paragraph\">Non. Contrairement \u00e0 plusieurs autres formes d\u2019amylose, l\u2019amylose AL est acquise au cours de la vie, et non port\u00e9e par vos g\u00e8nes. Elle ne peut pas \u00eatre transmise \u00e0 vos enfants, et vos proches ne courent pas un risque accru du fait de votre diagnostic.<\/p>\n\t\t\t<\/details>\n\t\t\t\n\t\t\t\n\t\t\t<details class=\"wp-block-details is-layout-flow wp-block-details-is-layout-flow\"><summary>L\u2019amylose AL peut-elle toucher le cerveau\u202f?<\/summary>\n\t\t\t<p class=\"wp-block-paragraph\">Non. Les d\u00e9p\u00f4ts amylo\u00efdes de cha\u00eenes l\u00e9g\u00e8res peuvent atteindre tous les organes du corps, sauf le cerveau. Les nerfs situ\u00e9s en dehors du cerveau et de la moelle \u00e9pini\u00e8re sont en revanche touch\u00e9s chez environ un patient sur cinq.<\/p>\n\t\t\t<\/details>\n\t\t\t\n\t\t\t\n\t\t\t<details class=\"wp-block-details is-layout-flow wp-block-details-is-layout-flow\"><summary>L\u2019amylose AL est-elle un cancer\u202f?<\/summary>\n\t\t\t<p class=\"wp-block-paragraph\">Elle commence par une anomalie clonale des plasmocytes de la moelle osseuse, la m\u00eame famille de cellules que dans le my\u00e9lome, et elle est trait\u00e9e par des h\u00e9matologues selon des protocoles issus du my\u00e9lome. Mais elle se comporte diff\u00e9remment, et lorsqu\u2019un my\u00e9lome accompagne l\u2019amylose, il est g\u00e9n\u00e9ralement indolent. Votre h\u00e9matologue est le mieux plac\u00e9 pour vous expliquer ce que cela signifie dans votre cas.<\/p>\n\t\t\t<\/details>\n\t\t\t\n\t\t\t\n\t\t\t<details class=\"wp-block-details is-layout-flow wp-block-details-is-layout-flow\"><summary>Que sont les cha\u00eenes l\u00e9g\u00e8res libres\u202f?<\/summary>\n\t\t\t<p class=\"wp-block-paragraph\">Les anticorps sont form\u00e9s de deux cha\u00eenes lourdes et de deux cha\u00eenes l\u00e9g\u00e8res. Lorsque des cha\u00eenes l\u00e9g\u00e8res sont produites en exc\u00e8s par un clone de plasmocytes, elles circulent seules dans le sang\u00a0: elles sont libres. Dans l\u2019amylose AL, ces cha\u00eenes l\u00e9g\u00e8res libres sont la mati\u00e8re premi\u00e8re des d\u00e9p\u00f4ts, c\u2019est pourquoi les mesurer indique \u00e0 votre \u00e9quipe si le traitement fonctionne.<\/p>\n\t\t\t<\/details>\n\t\t\t\n\t\t\t\n\t\t\t<details class=\"wp-block-details is-layout-flow wp-block-details-is-layout-flow\"><summary>Quelle est la diff\u00e9rence entre l\u2019amylose AL et l\u2019amylose ATTR\u202f?<\/summary>\n\t\t\t<p class=\"wp-block-paragraph\">Elles diff\u00e8rent par la prot\u00e9ine qui se replie mal. Dans l\u2019amylose AL, c\u2019est une cha\u00eene l\u00e9g\u00e8re d\u2019immunoglobuline fabriqu\u00e9e dans la moelle osseuse, et la maladie est acquise. Dans l\u2019amylose ATTR, c\u2019est la transthyr\u00e9tine, une prot\u00e9ine fabriqu\u00e9e par le foie\u202f; cette forme peut \u00eatre h\u00e9r\u00e9ditaire (ATTRv) ou li\u00e9e \u00e0 l\u2019\u00e2ge (ATTRwt). Comme les prot\u00e9ines d\u2019origine diff\u00e8rent, les traitements aussi, c\u2019est pourquoi le typage de la substance amylo\u00efde est une \u00e9tape si importante.<\/p>\n\t\t\t<\/details>\n\t\t\t\n\t\t<\/div>\n\t\t\n\t\t\n\t\t<div class=\"wp-block-group aa-tp-disclaimer is-layout-flow wp-block-group-is-layout-flow\">\n\t\t\t<p class=\"wp-block-paragraph\">Cette page est une information g\u00e9n\u00e9rale destin\u00e9e aux patients, aux familles et aux professionnels de sant\u00e9. Elle ne remplace pas un avis m\u00e9dical. Parlez toujours de votre situation avec votre \u00e9quipe sp\u00e9cialis\u00e9e.<\/p>\n\t\t<\/div>\n\t\t\n\t<\/div>\n\t\n<\/section>\n\n<section class=\"wp-block-group aa-next aa-next--split is-layout-flow wp-block-group-is-layout-flow\">\n\t\n\t<div class=\"wp-block-group aa-inner is-layout-flow wp-block-group-is-layout-flow\">\n\t\t\n\t\t<div class=\"wp-block-group aa-next__head is-layout-flow wp-block-group-is-layout-flow\">\n\t\t\t<p class=\"aa-section-num wp-block-paragraph\">Continuer<\/p>\n\t\t\t<h2 class=\"wp-block-heading\">Autres types<\/h2>\n\t\t<\/div>\n\t\t\n\t\t\n\t\t<div class=\"wp-block-group aa-next__grid is-layout-flow wp-block-group-is-layout-flow\">\n\t\t\t<div class=\"wp-block-group aa-next-card is-layout-flow wp-block-group-is-layout-flow\"><h3 class=\"wp-block-heading\"><a href=\"https:\/\/www.amyloidosisalliance.org\/fr\/types-damylose\/amylose-aa\/\">Amylose AA<\/a><\/h3><p class=\"wp-block-paragraph\">Due \u00e0 une inflammation de longue dur\u00e9e, et touchant presque exclusivement les reins.<\/p><\/div>\n\t\t\t<div class=\"wp-block-group aa-next-card is-layout-flow wp-block-group-is-layout-flow\"><h3 class=\"wp-block-heading\"><a href=\"https:\/\/www.amyloidosisalliance.org\/fr\/types-damylose\/amylose-attr\/\">Amylose ATTR<\/a><\/h3><p class=\"wp-block-paragraph\">Due \u00e0 la transthyr\u00e9tine, h\u00e9r\u00e9ditaire dans l\u2019ATTRv, li\u00e9e \u00e0 l\u2019\u00e2ge dans l\u2019ATTRwt.<\/p><\/div>\n\t\t\t<div class=\"wp-block-group aa-next-card is-layout-flow wp-block-group-is-layout-flow\"><h3 class=\"wp-block-heading\"><a href=\"https:\/\/www.amyloidosisalliance.org\/fr\/types-damylose\/autres-types\/\">Autres types<\/a><\/h3><p class=\"wp-block-paragraph\">Les formes h\u00e9r\u00e9ditaires rares, et l\u2019amylose localis\u00e9e, limit\u00e9e \u00e0 un seul site.<\/p><\/div>\n\t\t<\/div>\n\t\t\n\t<\/div>\n\t\n<\/section>\n","protected":false},"excerpt":{"rendered":"<p>Accueil\u203aAmylose\u203aTypes d\u2019amylose\u203aAmylose AL Types d\u2019amylose Amylose AL L\u2019amylose AL est l\u2019une des principales formes d\u2019amylose syst\u00e9mique. C\u2019est une maladie acquise, due \u00e0 des plasmocytes anormaux de la moelle osseuse qui produisent des cha\u00eenes l\u00e9g\u00e8res d\u2019immunoglobulines mal repli\u00e9es. Ces cha\u00eenes l\u00e9g\u00e8res peuvent former des d\u00e9p\u00f4ts amylo\u00efdes dans diff\u00e9rents organes. Comme l\u2019atteinte des organes peut progresser rapidement, [&hellip;]<\/p>\n","protected":false},"author":0,"featured_media":0,"parent":1427,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-1421","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Amylose AL\u00a0: sympt\u00f4mes, diagnostic et traitement<\/title>\n<meta name=\"description\" content=\"L\u2019amylose AL est due \u00e0 des plasmocytes anormaux qui produisent des cha\u00eenes l\u00e9g\u00e8res mal repli\u00e9es. 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