{"id":1417,"date":"2026-07-10T15:18:47","date_gmt":"2026-07-10T13:18:47","guid":{"rendered":"https:\/\/amyloidosisalliance.local\/amylose-attrwt\/"},"modified":"2026-09-29T11:03:55","modified_gmt":"2026-09-29T09:03:55","slug":"amylose-attrwt","status":"publish","type":"page","link":"https:\/\/www.amyloidosisalliance.org\/fr\/types-damylose\/amylose-attrwt\/","title":{"rendered":"Amylose ATTRwt"},"content":{"rendered":"\n<nav aria-label=\"Breadcrumb\" class=\"wp-block-group aa-breadcrumb aa-events-hero__crumb is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"aa-inner\"><a href=\"\/\">Accueil<\/a><span class=\"aa-breadcrumb__sep\">\u203a<\/span><span class=\"aa-breadcrumb__label\">Amylose<\/span><span class=\"aa-breadcrumb__sep\">\u203a<\/span><a href=\"https:\/\/www.amyloidosisalliance.org\/fr\/types-damylose\/\">Types d\u2019amylose<\/a><span class=\"aa-breadcrumb__sep\">\u203a<\/span><a href=\"https:\/\/www.amyloidosisalliance.org\/fr\/types-damylose\/amylose-attr\/\">Amylose ATTR<\/a><span class=\"aa-breadcrumb__sep\">\u203a<\/span><span class=\"aa-breadcrumb__current\">ATTRwt<\/span><\/div>\n<\/nav>\n\n<section class=\"wp-block-group aa-events-hero aa-events-hero--art aa-events-hero--attrwt is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-inner is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"aa-events-hero__kicker wp-block-paragraph\">Amylose ATTR<\/p>\n\n\n\n<h1 class=\"wp-block-heading\">Amylose ATTRwt<\/h1>\n\n\n\n<p class=\"wp-block-paragraph\">Dans l\u2019amylose ATTRwt, aucun variant pathog\u00e8ne de la TTR n\u2019est identifi\u00e9, mais la transthyr\u00e9tine peut devenir instable avec le vieillissement. La maladie n\u2019est pas h\u00e9r\u00e9ditaire. Elle se d\u00e9pose avant tout dans le c\u0153ur et a longtemps \u00e9t\u00e9 mise sur le compte du vieillissement ordinaire\u202f; elle peut pourtant \u00eatre identifi\u00e9e aujourd\u2019hui par un examen d\u2019imagerie, souvent sans biopsie.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-events-hero__art is-layout-flow wp-block-group-is-layout-flow\">\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" src=\"\/wp-content\/themes\/amyloidosis-alliance\/assets\/images\/disease\/attrwt.svg\" alt=\"Sch&#xE9;ma&#xA0;: la transthyr&#xE9;tine se dissocie en sous-unit&#xE9;s qui se replient mal, s&#x2019;alignent et s&#x2019;empilent en une fibrille amylo&#xEF;de\"\/><\/figure>\n<\/div>\n<\/section>\n\n<nav aria-label=\"Section navigation\" class=\"wp-block-group aa-anchorband is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-inner is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-columns aa-anchor-cols is-layout-flex wp-container-core-columns-is-layout-b2e659ba wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column aa-anchor-item is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"num wp-block-paragraph\">01<\/p>\n\n\n\n<p class=\"lbl wp-block-paragraph\"><a href=\"#what\">Qu\u2019est-ce que l\u2019ATTRwt\u202f?<\/a><\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column aa-anchor-item is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"num wp-block-paragraph\">02<\/p>\n\n\n\n<p class=\"lbl wp-block-paragraph\"><a href=\"#causes\">Comment elle se d\u00e9veloppe<\/a><\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column aa-anchor-item is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"num wp-block-paragraph\">03<\/p>\n\n\n\n<p class=\"lbl wp-block-paragraph\"><a href=\"#symptoms\">Sympt\u00f4mes<\/a><\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column aa-anchor-item is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"num wp-block-paragraph\">04<\/p>\n\n\n\n<p class=\"lbl wp-block-paragraph\"><a href=\"#diagnosis\">Diagnostic<\/a><\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column aa-anchor-item is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"num wp-block-paragraph\">05<\/p>\n\n\n\n<p class=\"lbl wp-block-paragraph\"><a href=\"#treatment\">Traitement<\/a><\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column aa-anchor-item is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"num wp-block-paragraph\">06<\/p>\n\n\n\n<p class=\"lbl wp-block-paragraph\"><a href=\"#early\">Diagnostic pr\u00e9coce<\/a><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/nav>\n\n<section id=\"what\" class=\"wp-block-group aa-section aa-section--white aa-what is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-inner is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"aa-section-num wp-block-paragraph\">01<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Qu\u2019est-ce que l\u2019ATTRwt\u202f?<\/h2>\n\n\n\n<div class=\"wp-block-group aa-key-idea is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"aa-key-idea__label wp-block-paragraph\">\u00c0 retenir<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u00ab\u00a0Wild-type\u00a0\u00bb signifie simplement non mut\u00e9. Tout le monde poss\u00e8de cette prot\u00e9ine. Chez certaines personnes, l\u2019\u00e2ge suffit \u00e0 la faire mal se replier.<\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-what-cols is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-what-col is-layout-flow wp-block-group-is-layout-flow\">\n<h4 class=\"wp-block-heading\">Une prot\u00e9ine de transport qui se d\u00e9r\u00e8gle<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">La transthyr\u00e9tine (TTR) est fabriqu\u00e9e par le foie et transporte l\u2019hormone thyro\u00efdienne dans l\u2019organisme. Tout le monde en poss\u00e8de, et dans l\u2019ATTRwt, le g\u00e8ne qui la code est <strong>tout \u00e0 fait normal<\/strong>\u00a0: c\u2019est ce que d\u00e9signe le terme \u00ab\u00a0wild-type\u00a0\u00bb.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Pour des raisons encore inexpliqu\u00e9es, la prot\u00e9ine change de forme au fil des ann\u00e9es. Elle devient insoluble, s\u2019agr\u00e8ge en fibrilles amylo\u00efdes, et ces fibrilles se d\u00e9posent dans les tissus.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-what-col is-layout-flow wp-block-group-is-layout-flow\">\n<h4 class=\"wp-block-heading\">Une maladie cardiaque du grand \u00e2ge<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Les d\u00e9p\u00f4ts s\u2019accumulent principalement dans le muscle cardiaque. On a longtemps parl\u00e9 d\u2019<em>amylose s\u00e9nile<\/em>, comme s\u2019il ne s\u2019agissait que du vieillissement du c\u0153ur.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">On pensait aussi qu\u2019elle ne touchait que les hommes blancs de plus de 75 ans. Elle est aujourd\u2019hui reconnue chez les femmes et chez des personnes de toutes origines, et elle peut commencer d\u00e8s 50 ans. Cette ancienne id\u00e9e re\u00e7ue est l\u2019une des raisons pour lesquelles le diagnostic est encore manqu\u00e9.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n\n<section id=\"causes\" class=\"wp-block-group aa-section aa-section--cream aa-forms is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-inner is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-centered-head is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"aa-section-num wp-block-paragraph\">02<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Comment l\u2019ATTRwt se d\u00e9veloppe<\/h2>\n\n\n\n<div class=\"aa-divider-dot\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">Pas de mutation, pas d\u2019inflammation, pas de clone de cellules anormales. Simplement une prot\u00e9ine ordinaire qui, avec le temps, ne garde plus sa forme.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-proc-grid is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-proc-step is-layout-flow wp-block-group-is-layout-flow\">\n<span class=\"aa-proc-step__icon\"><svg aria-hidden=\"true\" focusable=\"false\" width=\"24\" height=\"24\" viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><circle cx=\"12\" cy=\"12\" r=\"9\"><\/circle><circle cx=\"12\" cy=\"12\" r=\"3\"><\/circle><\/svg><\/span>\n\n\n\n<p class=\"aa-proc-step__num wp-block-paragraph\">\u00c9tape 01<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Une prot\u00e9ine normale<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">La transthyr\u00e9tine est produite par le foie et transporte l\u2019hormone thyro\u00efdienne. Son g\u00e8ne n\u2019est pas mut\u00e9\u00a0: c\u2019est la forme wild-type, la version ordinaire que nous portons tous.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-proc-step is-layout-flow wp-block-group-is-layout-flow\">\n<span class=\"aa-proc-step__icon\"><svg aria-hidden=\"true\" focusable=\"false\" width=\"24\" height=\"24\" viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><circle cx=\"12\" cy=\"12\" r=\"9\"><\/circle><polyline points=\"12 7 12 12 15.5 14\"><\/polyline><\/svg><\/span>\n\n\n\n<p class=\"aa-proc-step__num wp-block-paragraph\">\u00c9tape 02<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">L\u2019\u00e2ge la d\u00e9stabilise<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Avec les ann\u00e9es, et pour des raisons encore mal comprises, la prot\u00e9ine change de conformation. Elle perd sa solubilit\u00e9.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-proc-step is-layout-flow wp-block-group-is-layout-flow\">\n<span class=\"aa-proc-step__icon\"><svg aria-hidden=\"true\" focusable=\"false\" width=\"24\" height=\"24\" viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><polyline points=\"16 3 21 3 21 8\"><\/polyline><line x1=\"4\" y1=\"20\" x2=\"21\" y2=\"3\"><\/line><polyline points=\"21 16 21 21 16 21\"><\/polyline><line x1=\"15\" y1=\"15\" x2=\"21\" y2=\"21\"><\/line><line x1=\"4\" y1=\"4\" x2=\"9\" y2=\"9\"><\/line><\/svg><\/span>\n\n\n\n<p class=\"aa-proc-step__num wp-block-paragraph\">\u00c9tape 03<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Des fibrilles se forment<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">La prot\u00e9ine d\u00e9stabilis\u00e9e s\u2019agr\u00e8ge en fibrilles amylo\u00efdes insolubles, que l\u2019organisme n\u2019a aucun moyen d\u2019\u00e9liminer.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-proc-step is-layout-flow wp-block-group-is-layout-flow\">\n<span class=\"aa-proc-step__icon\"><svg aria-hidden=\"true\" focusable=\"false\" width=\"24\" height=\"24\" viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><path d=\"M19 14c1.49-1.46 3-3.21 3-5.5A5.5 5.5 0 0 0 16.5 3c-1.76 0-3 .5-4.5 2-1.5-1.5-2.74-2-4.5-2A5.5 5.5 0 0 0 2 8.5c0 2.29 1.51 4.04 3 5.5l7 7Z\"><\/path><\/svg><\/span>\n\n\n\n<p class=\"aa-proc-step__num wp-block-paragraph\">\u00c9tape 04<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Le c\u0153ur se rigidifie<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Les d\u00e9p\u00f4ts \u00e9paississent les parois des ventricules. Le c\u0153ur se remplit mal\u202f; plus tard, il se contracte moins bien, et le d\u00e9bit diminue.<\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-tp-alert aa-tp-alert--wide is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"wp-block-paragraph\">Un syndrome du canal carpien, souvent des deux mains, peut appara\u00eetre cinq \u00e0 dix ans avant tout signe cardiaque. Chez une personne \u00e2g\u00e9e, il m\u00e9rite qu\u2019on s\u2019y arr\u00eate.<\/p>\n<\/div>\n<\/div>\n<\/section>\n\n<section id=\"symptoms\" class=\"wp-block-group aa-section aa-section--white aa-tp-symptoms is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-inner is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-centered-head is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"aa-section-num wp-block-paragraph\">03<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Sympt\u00f4mes<\/h2>\n\n\n\n<div class=\"aa-divider-dot\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">Le c\u0153ur domine le tableau, mais il est rarement le premier \u00e0 se manifester. Les mains, les oreilles et les pieds donnent souvent l\u2019alerte des ann\u00e9es plus t\u00f4t.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-tp-organs aa-tp-organs--major is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-tp-organ is-layout-flow wp-block-group-is-layout-flow\">\n<h3 class=\"wp-block-heading\">Le c\u0153ur<\/h3>\n\n\n\n<p class=\"aa-tp-organ__tag wp-block-paragraph\">Remplissage et contraction<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Les parois des ventricules s\u2019\u00e9paississent et le muscle se rigidifie\u00a0: le c\u0153ur se remplit mal. Plus tard, sa contraction faiblit aussi, et le d\u00e9bit diminue. Cela entra\u00eene un essoufflement (d\u2019abord \u00e0 l\u2019effort, puis au repos, en parlant ou en position allong\u00e9e), ainsi que de la fatigue, un gonflement des jambes, une prise de poids et des palpitations.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-tp-organ is-layout-flow wp-block-group-is-layout-flow\">\n<h3 class=\"wp-block-heading\">Rythme cardiaque<\/h3>\n\n\n\n<p class=\"aa-tp-organ__tag wp-block-paragraph\">Une conduction perturb\u00e9e<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">La substance amylo\u00efde perturbe le syst\u00e8me \u00e9lectrique du c\u0153ur. Le rythme peut \u00eatre trop rapide ou trop lent, et dans certains cas le c\u0153ur peut s\u2019arr\u00eater. Un pacemaker ou un d\u00e9fibrillateur est parfois n\u00e9cessaire. Malaises, vertiges et palpitations sont les signes \u00e0 signaler.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-tp-organ is-layout-flow wp-block-group-is-layout-flow\">\n<h3 class=\"wp-block-heading\">Nerfs et audition<\/h3>\n\n\n\n<p class=\"aa-tp-organ__tag wp-block-paragraph\">Souvent n\u00e9glig\u00e9s<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">L\u2019audition peut baisser. Les pieds peuvent donner l\u2019impression d\u2019\u00eatre envelopp\u00e9s de coton, ou picoter de fourmillements. Pris isol\u00e9ment, ces signes ressemblent aux plaintes ordinaires de l\u2019\u00e2ge, et c\u2019est pr\u00e9cis\u00e9ment l\u00e0 toute la difficult\u00e9.<\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-tp-organs aa-tp-organs--minor is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-tp-organ is-layout-flow wp-block-group-is-layout-flow\">\n<h3 class=\"wp-block-heading\">Syndrome du canal carpien<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Souvent le tout premier signe, et souvent des deux mains \u00e0 la fois. Il peut pr\u00e9c\u00e9der les sympt\u00f4mes cardiaques de cinq \u00e0 dix ans.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-tp-organ is-layout-flow wp-block-group-is-layout-flow\">\n<h3 class=\"wp-block-heading\">La vie quotidienne<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Monter les escaliers devient p\u00e9nible. Se lever provoque des vertiges. Le poids diminue sans explication, et le transit alterne entre diarrh\u00e9e et constipation.<\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-tp-flags is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-tp-flags__photo is-layout-flow wp-block-group-is-layout-flow\">\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"683\" height=\"1024\" src=\"https:\/\/www.amyloidosisalliance.org\/wp-content\/uploads\/2026\/09\/anatomical-model-of-a-human-heart-683x1024.jpg\" alt=\"Mod&#xE8;le anatomique d&#x2019;un c&#x153;ur humain\" class=\"wp-image-698\" srcset=\"https:\/\/www.amyloidosisalliance.org\/wp-content\/uploads\/2026\/09\/anatomical-model-of-a-human-heart-683x1024.jpg 683w, https:\/\/www.amyloidosisalliance.org\/wp-content\/uploads\/2026\/09\/anatomical-model-of-a-human-heart-200x300.jpg 200w, https:\/\/www.amyloidosisalliance.org\/wp-content\/uploads\/2026\/09\/anatomical-model-of-a-human-heart-768x1152.jpg 768w, https:\/\/www.amyloidosisalliance.org\/wp-content\/uploads\/2026\/09\/anatomical-model-of-a-human-heart-1024x1536.jpg 1024w, https:\/\/www.amyloidosisalliance.org\/wp-content\/uploads\/2026\/09\/anatomical-model-of-a-human-heart-1365x2048.jpg 1365w\" sizes=\"auto, (max-width: 683px) 100vw, 683px\" \/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-tp-flags__body is-layout-flow wp-block-group-is-layout-flow\">\n<h3 class=\"wp-block-heading\">Quand consulter<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Chacun de ces signes est fr\u00e9quent \u00e0 lui seul avec l\u2019\u00e2ge. Plusieurs ensemble, et surtout associ\u00e9s \u00e0 un c\u0153ur \u00e9paissi que personne n\u2019a pu expliquer, m\u00e9ritent d\u2019\u00eatre explor\u00e9s.<\/p>\n\n\n\n<ul class=\"wp-block-list aa-tp-flags__list\">\n<li>Des chevilles gonfl\u00e9es, qui remontent vers les jambes<\/li>\n\n\n\n<li>Des palpitations ou un rythme cardiaque irr\u00e9gulier<\/li>\n\n\n\n<li>Fatigue et faiblesse<\/li>\n\n\n\n<li>Un essoufflement au moindre effort<\/li>\n\n\n\n<li>Des difficult\u00e9s \u00e0 monter les escaliers<\/li>\n\n\n\n<li>Engourdissements ou fourmillements dans les mains et les pieds<\/li>\n\n\n\n<li>Des vertiges en se levant<\/li>\n\n\n\n<li>Diarrh\u00e9e alternant avec une constipation<\/li>\n\n\n\n<li>Une perte de poids involontaire<\/li>\n<\/ul>\n\n\n\n<div class=\"wp-block-group aa-tp-alert is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"wp-block-paragraph\">Un c\u0153ur \u00e9paissi inexpliqu\u00e9 chez une personne \u00e2g\u00e9e, associ\u00e9 \u00e0 un syndrome du canal carpien des deux mains, doit faire rechercher une amylose ATTR.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n\n<section id=\"diagnosis\" class=\"wp-block-group aa-section aa-section--cream aa-tp-dx is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-inner is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-tp-dx__body is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"aa-section-num wp-block-paragraph\">04<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Comment l\u2019ATTRwt est diagnostiqu\u00e9e<\/h2>\n\n\n\n<p class=\"aa-tp-dx__intro wp-block-paragraph\">C\u2019est l\u00e0 que l\u2019ATTRwt se distingue de toutes les autres formes d\u2019amylose. Dans la plupart des cas, le diagnostic peut aujourd\u2019hui \u00eatre pos\u00e9 gr\u00e2ce \u00e0 un examen d\u2019imagerie, sans pr\u00e9lever de fragment du c\u0153ur. C\u2019est l\u2019une des v\u00e9ritables avanc\u00e9es de ces vingt derni\u00e8res ann\u00e9es.<\/p>\n\n\n\n<div class=\"wp-block-group aa-tp-dx__steps is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-tp-dx__step is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"aa-tp-dx__step-num wp-block-paragraph\">01<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Examiner le c\u0153ur<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">L\u2019\u00e9chocardiographie, ou l\u2019IRM cardiaque, montre l\u2019\u00e9paississement des parois des ventricules. C\u2019est g\u00e9n\u00e9ralement ce qui \u00e9veille le soup\u00e7on en premier lieu.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-tp-dx__step is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"aa-tp-dx__step-num wp-block-paragraph\">02<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">La scintigraphie osseuse<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Le muscle cardiaque fixe un traceur osseux\u00a0: une image frappante et tr\u00e8s caract\u00e9ristique. Lorsqu\u2019aucun autre type d\u2019amylose n\u2019est suspect\u00e9, cela suffit \u00e0 poser le diagnostic, sans biopsie.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-tp-dx__step is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"aa-tp-dx__step-num wp-block-paragraph\">03<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">\u00c9carter l\u2019amylose AL<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">On recherche dans le sang et les urines les cha\u00eenes l\u00e9g\u00e8res monoclonales de l\u2019amylose AL, qui se traite de fa\u00e7on totalement diff\u00e9rente. En cas de doute, une biopsie est r\u00e9alis\u00e9e, des glandes salivaires, et parfois du c\u0153ur lui-m\u00eame.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-tp-dx__step is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"aa-tp-dx__step-num wp-block-paragraph\">04<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Un test g\u00e9n\u00e9tique<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">C\u2019est le <strong>seul<\/strong> moyen de savoir si la transthyr\u00e9tine est mut\u00e9e (amylose ATTR h\u00e9r\u00e9ditaire) ou wild-type. La r\u00e9ponse compte pour vous, et pour votre famille.<\/p>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-tp-dx__photo is-layout-flow wp-block-group-is-layout-flow\">\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"683\" src=\"https:\/\/www.amyloidosisalliance.org\/wp-content\/uploads\/2026\/09\/a-row-of-microscopes-in-a-laboratory-1024x683.jpg\" alt=\"Une rang&#xE9;e de microscopes dans un laboratoire\" class=\"wp-image-699\" srcset=\"https:\/\/www.amyloidosisalliance.org\/wp-content\/uploads\/2026\/09\/a-row-of-microscopes-in-a-laboratory-1024x683.jpg 1024w, https:\/\/www.amyloidosisalliance.org\/wp-content\/uploads\/2026\/09\/a-row-of-microscopes-in-a-laboratory-300x200.jpg 300w, https:\/\/www.amyloidosisalliance.org\/wp-content\/uploads\/2026\/09\/a-row-of-microscopes-in-a-laboratory-768x512.jpg 768w, https:\/\/www.amyloidosisalliance.org\/wp-content\/uploads\/2026\/09\/a-row-of-microscopes-in-a-laboratory-1536x1024.jpg 1536w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n<\/div>\n<\/div>\n<\/section>\n\n<section id=\"treatment\" class=\"wp-block-group aa-section aa-section--white aa-treating is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-inner is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-centered-head is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"aa-section-num wp-block-paragraph\">05<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Traitement<\/h2>\n\n\n\n<div class=\"aa-divider-dot\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">Le traitement vise \u00e0 ralentir ou \u00e0 emp\u00eacher la formation de nouvelle substance amylo\u00efde, et \u00e0 prendre en charge les sympt\u00f4mes et les complications cardiaques. Les traitements de fond agissent sur la transthyr\u00e9tine elle-m\u00eame ou sur sa production, tandis que le traitement symptomatique est adapt\u00e9 \u00e0 chaque patient.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-tp-treat-lead is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-tp-treat-lead__photo is-layout-flow wp-block-group-is-layout-flow\">\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"683\" src=\"https:\/\/www.amyloidosisalliance.org\/wp-content\/uploads\/2026\/09\/a-pharmacist-selecting-medicines-from-a-shelf-1024x683.jpg\" alt=\"Une pharmacienne choisissant des m&#xE9;dicaments sur une &#xE9;tag&#xE8;re\" class=\"wp-image-700\" srcset=\"https:\/\/www.amyloidosisalliance.org\/wp-content\/uploads\/2026\/09\/a-pharmacist-selecting-medicines-from-a-shelf-1024x683.jpg 1024w, https:\/\/www.amyloidosisalliance.org\/wp-content\/uploads\/2026\/09\/a-pharmacist-selecting-medicines-from-a-shelf-300x200.jpg 300w, https:\/\/www.amyloidosisalliance.org\/wp-content\/uploads\/2026\/09\/a-pharmacist-selecting-medicines-from-a-shelf-768x512.jpg 768w, https:\/\/www.amyloidosisalliance.org\/wp-content\/uploads\/2026\/09\/a-pharmacist-selecting-medicines-from-a-shelf-1536x1024.jpg 1536w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-tp-treat-lead__body is-layout-flow wp-block-group-is-layout-flow\">\n<h3 class=\"wp-block-heading\">Stabiliser la prot\u00e9ine<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Les stabilisateurs de la TTR sont une option de traitement de fond pour les patients \u00e9ligibles atteints de cardiomyopathie ATTR. Ils se fixent sur la transthyr\u00e9tine et contribuent \u00e0 stabiliser la prot\u00e9ine, ce qui r\u00e9duit sa tendance \u00e0 mal se replier et \u00e0 former de nouvelles fibrilles amylo\u00efdes. Les indications autoris\u00e9es et l\u2019acc\u00e8s varient d\u2019un pays \u00e0 l\u2019autre.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">D\u2019autres approches de fond peuvent r\u00e9duire la production de transthyr\u00e9tine ou cibler les d\u00e9p\u00f4ts amylo\u00efdes. Leur autorisation, leur disponibilit\u00e9 et leur place dans le traitement varient d\u2019un pays \u00e0 l\u2019autre et doivent \u00eatre discut\u00e9es avec une \u00e9quipe sp\u00e9cialis\u00e9e.<\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-treating-grid is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-treating-card is-layout-flow wp-block-group-is-layout-flow\">\n<span class=\"aa-icon-tile\"><svg aria-hidden=\"true\" focusable=\"false\" width=\"24\" height=\"24\" viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><path d=\"M12 22s8-4 8-10V5l-8-3-8 3v7c0 6 8 10 8 10z\"><\/path><\/svg><\/span>\n\n\n\n<h3 class=\"wp-block-heading\">Stabilisateurs<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Les stabilisateurs de la TTR se fixent sur la transthyr\u00e9tine et contribuent \u00e0 maintenir la prot\u00e9ine stable, ce qui r\u00e9duit sa tendance \u00e0 mal se replier et \u00e0 former des fibrilles amylo\u00efdes. La disponibilit\u00e9 et les indications autoris\u00e9es varient d\u2019un pays \u00e0 l\u2019autre.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-treating-card is-layout-flow wp-block-group-is-layout-flow\">\n<span class=\"aa-icon-tile\"><svg aria-hidden=\"true\" focusable=\"false\" width=\"24\" height=\"24\" viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><path d=\"M2 15c6.667-6 13.333 0 20-6\"><\/path><path d=\"M2 9c6.667 6 13.333 0 20 6\"><\/path><line x1=\"7\" y1=\"6\" x2=\"9\" y2=\"8\"><\/line><line x1=\"15\" y1=\"16\" x2=\"17\" y2=\"18\"><\/line><\/svg><\/span>\n\n\n\n<h3 class=\"wp-block-heading\">Silenceurs de g\u00e8ne<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Les th\u00e9rapies de silen\u00e7age du g\u00e8ne TTR agissent plus en amont, en r\u00e9duisant la quantit\u00e9 de transthyr\u00e9tine produite par le foie. Leur utilisation dans la cardiomyopathie ATTRwt d\u00e9pend de l\u2019autorisation r\u00e9glementaire locale et de l\u2019indication clinique.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-treating-card is-layout-flow wp-block-group-is-layout-flow\">\n<span class=\"aa-icon-tile\"><svg aria-hidden=\"true\" focusable=\"false\" width=\"24\" height=\"24\" viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><path d=\"M12 3l2.5 6.5L21 12l-6.5 2.5L12 21l-2.5-6.5L3 12l6.5-2.5z\"><\/path><\/svg><\/span>\n\n\n\n<h3 class=\"wp-block-heading\">Pour demain<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Des th\u00e9rapies con\u00e7ues pour favoriser l\u2019\u00e9limination de la substance amylo\u00efde et d\u2019autres approches de fond sont \u00e0 l\u2019\u00e9tude. Leur r\u00f4le futur d\u00e9pendra des r\u00e9sultats des essais cliniques et des autorisations r\u00e9glementaires.<\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-tp-support is-layout-flow wp-block-group-is-layout-flow\">\n<h4 class=\"wp-block-heading\">Prendre soin du c\u0153ur, et ce qu\u2019il faut \u00e9viter<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">R\u00e9duire le sel, associ\u00e9 \u00e0 des diur\u00e9tiques, soulage l\u2019essoufflement et les gonflements. Lorsque le rythme est irr\u00e9gulier, un traitement anticoagulant est utilis\u00e9 pour \u00e9viter la formation de caillots dans le c\u0153ur.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Il y a un pi\u00e8ge \u00e0 conna\u00eetre. Plusieurs m\u00e9dicaments prescrits couramment dans l\u2019insuffisance cardiaque ordinaire, dont les b\u00eatabloquants et les vasodilatateurs, peuvent aggraver l\u2019ATTRwt, et sont parfois arr\u00eat\u00e9s. Cette d\u00e9cision revient \u00e0 votre cardiologue. N\u2019arr\u00eatez jamais un traitement de vous-m\u00eame.<\/p>\n<\/div>\n<\/div>\n<\/section>\n\n<section id=\"early\" class=\"wp-block-group aa-section aa-section--forest aa-tp-outlook is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-inner is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-tp-outlook__photo is-layout-flow wp-block-group-is-layout-flow\">\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"683\" src=\"https:\/\/www.amyloidosisalliance.org\/wp-content\/uploads\/2026\/09\/an-intravenous-drip-stand-in-a-hospital-room-1024x683.jpg\" alt=\"Un pied &#xE0; perfusion dans une chambre d&#x2019;h&#xF4;pital\" class=\"wp-image-701\" srcset=\"https:\/\/www.amyloidosisalliance.org\/wp-content\/uploads\/2026\/09\/an-intravenous-drip-stand-in-a-hospital-room-1024x683.jpg 1024w, https:\/\/www.amyloidosisalliance.org\/wp-content\/uploads\/2026\/09\/an-intravenous-drip-stand-in-a-hospital-room-300x200.jpg 300w, https:\/\/www.amyloidosisalliance.org\/wp-content\/uploads\/2026\/09\/an-intravenous-drip-stand-in-a-hospital-room-768x512.jpg 768w, https:\/\/www.amyloidosisalliance.org\/wp-content\/uploads\/2026\/09\/an-intravenous-drip-stand-in-a-hospital-room-1536x1024.jpg 1536w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-tp-outlook__body is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"aa-section-num wp-block-paragraph\">06<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pourquoi le diagnostic pr\u00e9coce compte<\/h2>\n\n\n\n<h4 class=\"wp-block-heading\">Rep\u00e9r\u00e9e avant l\u2019\u00e9paississement des parois<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Une atteinte ailleurs dans l\u2019organisme peut r\u00e9v\u00e9ler la maladie cardiaque \u00e0 un stade tr\u00e8s pr\u00e9coce, avant m\u00eame tout \u00e9paississement des parois des ventricules. L\u2019examen trouve ce que le c\u0153ur n\u2019a pas encore eu le temps de montrer.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Les signes qui viennent en premier<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Un syndrome du canal carpien des deux mains. Une audition qui baisse. Des pieds qui fourmillent. Chacun de ces signes est facile \u00e0 ranger du c\u00f4t\u00e9 de la vieillesse\u202f; ensemble, des ann\u00e9es avant tout essoufflement, ils sont les tout premiers signes que donne cette maladie.<\/p>\n\n\n\n<p class=\"aa-tp-outlook__closing wp-block-paragraph\">Pendant longtemps, on l\u2019a simplement mise sur le compte de la vieillesse. Elle a aujourd\u2019hui un nom, un examen, et un traitement.<\/p>\n<\/div>\n<\/div>\n<\/section>\n\n<section class=\"wp-block-group aa-section aa-section--white aa-tp-faq is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-inner is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-centered-head is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"aa-section-num wp-block-paragraph\">FAQ<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Questions fr\u00e9quentes<\/h2>\n\n\n\n<div class=\"aa-divider-dot\"><\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-acc is-layout-flow wp-block-group-is-layout-flow\">\n<details class=\"wp-block-details is-layout-flow wp-block-details-is-layout-flow\"><summary>L\u2019ATTRwt est-elle h\u00e9r\u00e9ditaire\u202f?<\/summary>\n<p class=\"wp-block-paragraph\">Non. Dans l\u2019ATTRwt, le g\u00e8ne de la transthyr\u00e9tine ne porte aucune mutation, et rien n\u2019est transmis \u00e0 vos enfants. Mais les deux formes ne peuvent pas \u00eatre distingu\u00e9es par leurs sympt\u00f4mes\u00a0: c\u2019est pr\u00e9cis\u00e9ment pourquoi un test g\u00e9n\u00e9tique fait partie du diagnostic. Il distingue la forme wild-type de l\u2019amylose ATTR h\u00e9r\u00e9ditaire, pour laquelle un test peut devoir \u00eatre propos\u00e9 aux proches.<\/p>\n<\/details>\n\n\n\n<details class=\"wp-block-details is-layout-flow wp-block-details-is-layout-flow\"><summary>Pourquoi parle-t-on de \u00ab\u00a0wild-type\u00a0\u00bb\u202f?<\/summary>\n<p class=\"wp-block-paragraph\">\u00ab\u00a0Wild-type\u00a0\u00bb est le terme des biologistes pour d\u00e9signer un g\u00e8ne ou une prot\u00e9ine dans son \u00e9tat ordinaire, non modifi\u00e9, par opposition \u00e0 un variant mut\u00e9. Il ne dit rien de l\u2019agressivit\u00e9 de la maladie. Il signifie simplement\u00a0: la prot\u00e9ine que tout le monde poss\u00e8de.<\/p>\n<\/details>\n\n\n\n<details class=\"wp-block-details is-layout-flow wp-block-details-is-layout-flow\"><summary>Un syndrome du canal carpien signifie-t-il que j\u2019ai une ATTRwt\u202f?<\/summary>\n<p class=\"wp-block-paragraph\">Presque toujours, non. Le syndrome du canal carpien est fr\u00e9quent et n\u2019a g\u00e9n\u00e9ralement rien \u00e0 voir avec l\u2019amylose. Ce qui m\u00e9rite d\u2019\u00eatre explor\u00e9, c\u2019est l\u2019association\u00a0: un canal carpien des deux mains, chez une personne \u00e2g\u00e9e, avec un c\u0153ur \u00e9paissi que personne n\u2019a pu expliquer.<\/p>\n<\/details>\n\n\n\n<details class=\"wp-block-details is-layout-flow wp-block-details-is-layout-flow\"><summary>Aurai-je besoin d\u2019une biopsie cardiaque\u202f?<\/summary>\n<p class=\"wp-block-paragraph\">En g\u00e9n\u00e9ral, non. La scintigraphie osseuse permet de poser le diagnostic sans biopsie, \u00e0 condition qu\u2019aucun autre type d\u2019amylose ne soit suspect\u00e9. La biopsie est r\u00e9serv\u00e9e aux cas o\u00f9 un doute persiste, et elle est souvent r\u00e9alis\u00e9e sur les glandes salivaires plut\u00f4t que sur le c\u0153ur.<\/p>\n<\/details>\n\n\n\n<details class=\"wp-block-details is-layout-flow wp-block-details-is-layout-flow\"><summary>Qu\u2019est-ce que la transthyr\u00e9tine\u202f?<\/summary>\n<p class=\"wp-block-paragraph\">Une prot\u00e9ine fabriqu\u00e9e par le foie, dont le r\u00f4le est de transporter l\u2019hormone thyro\u00efdienne dans le sang. Tout le monde en poss\u00e8de. Dans l\u2019amylose ATTR, elle perd sa forme et s\u2019agr\u00e8ge, soit parce que le g\u00e8ne est mut\u00e9 (amylose ATTR h\u00e9r\u00e9ditaire), soit, comme ici, simplement avec l\u2019\u00e2ge.<\/p>\n<\/details>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-tp-disclaimer is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"wp-block-paragraph\">Cette page est une information g\u00e9n\u00e9rale destin\u00e9e aux patients, aux familles et aux professionnels de sant\u00e9. Elle ne remplace pas un avis m\u00e9dical. Les indications autoris\u00e9es, le remboursement et la disponibilit\u00e9 des traitements de l\u2019amylose ATTR varient d\u2019un pays \u00e0 l\u2019autre. Les patients doivent discuter des options disponibles localement avec leur \u00e9quipe sp\u00e9cialis\u00e9e.<\/p>\n<\/div>\n<\/div>\n<\/section>\n\n<section class=\"wp-block-group aa-next aa-next--split is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-inner is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-next__head is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"aa-section-num wp-block-paragraph\">Continuer<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Autres types<\/h2>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-next__grid is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-next-card is-layout-flow wp-block-group-is-layout-flow\">\n<h3 class=\"wp-block-heading\"><a href=\"https:\/\/www.amyloidosisalliance.org\/fr\/types-damylose\/amylose-attrv\/\">ATTRv<\/a><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">La forme h\u00e9r\u00e9ditaire de l\u2019amylose ATTR, due \u00e0 une mutation du g\u00e8ne de la transthyr\u00e9tine.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-next-card is-layout-flow wp-block-group-is-layout-flow\">\n<h3 class=\"wp-block-heading\"><a href=\"https:\/\/www.amyloidosisalliance.org\/fr\/types-damylose\/amylose-al\/\">Amylose AL<\/a><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">La forme syst\u00e9mique la plus fr\u00e9quente, due aux cha\u00eenes l\u00e9g\u00e8res produites dans la moelle osseuse.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-next-card is-layout-flow wp-block-group-is-layout-flow\">\n<h3 class=\"wp-block-heading\"><a href=\"https:\/\/www.amyloidosisalliance.org\/fr\/types-damylose\/amylose-aa\/\">Amylose AA<\/a><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Une complication d\u2019une inflammation de longue dur\u00e9e, qui touche avant tout les reins.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n","protected":false},"excerpt":{"rendered":"<p>Accueil\u203aAmylose\u203aTypes d\u2019amylose\u203aAmylose ATTR\u203aATTRwt Amylose ATTR Amylose ATTRwt Dans l\u2019amylose ATTRwt, aucun variant pathog\u00e8ne de la TTR n\u2019est identifi\u00e9, mais la transthyr\u00e9tine peut devenir instable avec le vieillissement. La maladie n\u2019est pas h\u00e9r\u00e9ditaire. Elle se d\u00e9pose avant tout dans le c\u0153ur et a longtemps \u00e9t\u00e9 mise sur le compte du vieillissement ordinaire\u202f; elle peut pourtant \u00eatre [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":1427,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-1417","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Amylose ATTRwt\u00a0: la forme wild-type de l\u2019amylose ATTR<\/title>\n<meta name=\"description\" content=\"Dans l\u2019amylose ATTRwt, aucun variant de la TTR n\u2019est retrouv\u00e9\u00a0: la prot\u00e9ine se d\u00e9stabilise avec l\u2019\u00e2ge. 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