{"id":1409,"date":"2026-07-10T16:36:41","date_gmt":"2026-07-10T14:36:41","guid":{"rendered":"https:\/\/amyloidosisalliance.local\/amylose-attr\/"},"modified":"2026-09-29T11:03:51","modified_gmt":"2026-09-29T09:03:51","slug":"amylose-attr","status":"publish","type":"page","link":"https:\/\/www.amyloidosisalliance.org\/fr\/types-damylose\/amylose-attr\/","title":{"rendered":"Amylose ATTR"},"content":{"rendered":"\n<nav class=\"wp-block-group aa-breadcrumb aa-events-hero__crumb is-layout-flow wp-block-group-is-layout-flow\" aria-label=\"Breadcrumb\">\n\t\n\t<div class=\"aa-inner\"><a href=\"\/\">Accueil<\/a><span class=\"aa-breadcrumb__sep\">\u203a<\/span><span class=\"aa-breadcrumb__label\">Amylose<\/span><span class=\"aa-breadcrumb__sep\">\u203a<\/span><a href=\"https:\/\/www.amyloidosisalliance.org\/fr\/types-damylose\/\">Types d\u2019amylose<\/a><span class=\"aa-breadcrumb__sep\">\u203a<\/span><span class=\"aa-breadcrumb__current\">Amylose ATTR<\/span><\/div>\n\t\n<\/nav>\n\n<section class=\"wp-block-group aa-events-hero aa-events-hero--art aa-events-hero--attr is-layout-flow wp-block-group-is-layout-flow\">\n\t\n\t<div class=\"wp-block-group aa-inner is-layout-flow wp-block-group-is-layout-flow\">\n\t\t<p class=\"aa-events-hero__kicker wp-block-paragraph\">Types d\u2019amylose<\/p>\n\t\t<h1 class=\"wp-block-heading\">Amylose ATTR<\/h1>\n\t\t<p class=\"wp-block-paragraph\">La transthyr\u00e9tine est une prot\u00e9ine fabriqu\u00e9e par le foie, dont le r\u00f4le est de transporter l\u2019hormone thyro\u00efdienne dans le sang. Tout le monde en poss\u00e8de. Dans l\u2019amylose ATTR, elle perd sa forme, s\u2019agr\u00e8ge en fibrilles et se d\u00e9pose dans les tissus, avant tout dans le c\u0153ur. Deux causes bien diff\u00e9rentes peuvent d\u00e9clencher ce processus, et les distinguer est la premi\u00e8re t\u00e2che.<\/p>\n\t<\/div>\n\t\n\t\n\t<div class=\"wp-block-group aa-events-hero__art is-layout-flow wp-block-group-is-layout-flow\">\n\t\t\n\t\t<figure class=\"wp-block-image size-full\"><img decoding=\"async\" src=\"\/wp-content\/themes\/amyloidosis-alliance\/assets\/images\/disease\/attr.svg\" alt=\"Sch&#xE9;ma&#xA0;: la transthyr&#xE9;tine se dissocie, avec l&#x2019;&#xE2;ge ou &#xE0; cause d&#x2019;un variant h&#xE9;r&#xE9;ditaire, et ses sous-unit&#xE9;s se replient mal, s&#x2019;alignent et s&#x2019;empilent en une fibrille amylo&#xEF;de\"\/><\/figure>\n\t\t\n\t<\/div>\n\t\n<\/section>\n\n<section class=\"wp-block-group aa-section aa-section--white aa-what is-layout-flow wp-block-group-is-layout-flow\" id=\"what\">\n\t\n\t<div class=\"wp-block-group aa-inner is-layout-flow wp-block-group-is-layout-flow\">\n\t\t\n\t\t<div class=\"wp-block-group is-layout-flow wp-block-group-is-layout-flow\">\n\t\t\t<p class=\"aa-section-num wp-block-paragraph\">01<\/p>\n\t\t\t<h2 class=\"wp-block-heading\">Une prot\u00e9ine<\/h2>\n\t\t\t\n\t\t\t<div class=\"wp-block-group aa-key-idea is-layout-flow wp-block-group-is-layout-flow\">\n\t\t\t\t<p class=\"aa-key-idea__label wp-block-paragraph\">\u00c0 retenir<\/p>\n\t\t\t\t<p class=\"wp-block-paragraph\">Une prot\u00e9ine, deux maladies. Un test g\u00e9n\u00e9tique est n\u00e9cessaire pour savoir si l\u2019amylose ATTR est h\u00e9r\u00e9ditaire ou wild-type, et son r\u00e9sultat peut aussi avoir des cons\u00e9quences pour les proches.<\/p>\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\n\t\t\n\t\t<div class=\"wp-block-group aa-what-cols is-layout-flow wp-block-group-is-layout-flow\">\n\t\t\t\n\t\t\t<div class=\"wp-block-group aa-what-col is-layout-flow wp-block-group-is-layout-flow\">\n\t\t\t\t<h4 class=\"wp-block-heading\">Une prot\u00e9ine de transport<\/h4>\n\t\t\t\t<p class=\"wp-block-paragraph\">La transthyr\u00e9tine, ou TTR, est produite par le foie et transporte l\u2019hormone thyro\u00efdienne dans l\u2019organisme. C\u2019est une prot\u00e9ine ordinaire, que tout le monde poss\u00e8de.<\/p>\n\t\t\t\t<p class=\"wp-block-paragraph\">Lorsqu\u2019elle devient instable, elle change de forme, perd sa solubilit\u00e9 et s\u2019agr\u00e8ge en fibrilles amylo\u00efdes que l\u2019organisme ne sait pas \u00e9liminer. Ce qui la rend instable est pr\u00e9cis\u00e9ment ce qui distingue les deux formes de la maladie.<\/p>\n\t\t\t<\/div>\n\t\t\t\n\t\t\t\n\t\t\t<div class=\"wp-block-group aa-what-col is-layout-flow wp-block-group-is-layout-flow\">\n\t\t\t\t<h4 class=\"wp-block-heading\">O\u00f9 elle se d\u00e9pose<\/h4>\n\t\t\t\t<p class=\"wp-block-paragraph\">Principalement dans le <strong>c\u0153ur<\/strong>, o\u00f9 les d\u00e9p\u00f4ts \u00e9paississent et rigidifient les parois des ventricules jusqu\u2019\u00e0 ce que les cavit\u00e9s ne se remplissent plus correctement. Les nerfs sont aussi souvent touch\u00e9s, en particulier dans la forme h\u00e9r\u00e9ditaire.<\/p>\n\t\t\t\t<p class=\"wp-block-paragraph\">Un syndrome du canal carpien, souvent des deux mains, appara\u00eet fr\u00e9quemment cinq \u00e0 dix ans avant tout sympt\u00f4me cardiaque. C\u2019est souvent le tout premier signe que donne cette maladie.<\/p>\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\n\t<\/div>\n\t\n<\/section>\n\n<section class=\"wp-block-group aa-section aa-section--cream aa-tp-duo-sec is-layout-flow wp-block-group-is-layout-flow\" id=\"forms\">\n\t\n\t<div class=\"wp-block-group aa-inner is-layout-flow wp-block-group-is-layout-flow\">\n\t\t\n\t\t<div class=\"wp-block-group aa-centered-head is-layout-flow wp-block-group-is-layout-flow\">\n\t\t\t<p class=\"aa-section-num wp-block-paragraph\">02<\/p>\n\t\t\t<h2 class=\"wp-block-heading\">Deux chemins vers la m\u00eame prot\u00e9ine<\/h2>\n\t\t\t<div class=\"aa-divider-dot\"><\/div>\n\t\t\t<p class=\"wp-block-paragraph\">Soit le g\u00e8ne est normal et c\u2019est l\u2019\u00e2ge qui d\u00e9stabilise la prot\u00e9ine, soit une mutation la d\u00e9stabilise d\u2019embl\u00e9e. Tout le reste en d\u00e9coule.<\/p>\n\t\t<\/div>\n\t\t\n\t\t\n\t\t<div class=\"wp-block-group aa-tp-duo is-layout-flow wp-block-group-is-layout-flow\">\n\t\t\t\n\t\t\t<div class=\"wp-block-group aa-tp-duo__card is-layout-flow wp-block-group-is-layout-flow\">\n\t\t\t\t<p class=\"aa-tp-duo__tag wp-block-paragraph\">ATTRwt<\/p>\n\t\t\t\t<h3 class=\"wp-block-heading\">Wild-type, acquise avec l\u2019\u00e2ge<\/h3>\n\t\t\t\t<p class=\"wp-block-paragraph\">Dans l\u2019amylose ATTRwt, aucun variant pathog\u00e8ne de la TTR n\u2019est identifi\u00e9. Le vieillissement est le principal facteur de risque reconnu. C\u2019est une maladie de l\u2019\u00e2ge avanc\u00e9, domin\u00e9e par l\u2019atteinte cardiaque, et longtemps consid\u00e9r\u00e9e \u00e0 tort comme un simple vieillissement du c\u0153ur.<\/p>\n\t\t\t\t<p class=\"wp-block-paragraph\">Elle n\u2019est pas h\u00e9r\u00e9ditaire, et rien n\u2019est transmis \u00e0 vos enfants.<\/p>\n\t\t\t\t\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\"><div class=\"wp-block-button aa-btn aa-btn--teal\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.amyloidosisalliance.org\/fr\/types-damylose\/amylose-attrwt\/\">En savoir plus sur l\u2019ATTRwt \u2192<\/a><\/div><\/div>\n\n\t\t\t<\/div>\n\t\t\t\n\t\t\t\n\t\t\t<div class=\"wp-block-group aa-tp-duo__card is-layout-flow wp-block-group-is-layout-flow\">\n\t\t\t\t<p class=\"aa-tp-duo__tag wp-block-paragraph\">ATTRv<\/p>\n\t\t\t\t<h3 class=\"wp-block-heading\">H\u00e9r\u00e9ditaire, inscrite dans le g\u00e8ne<\/h3>\n\t\t\t\t<p class=\"wp-block-paragraph\">Une mutation du g\u00e8ne TTR, h\u00e9rit\u00e9e d\u2019un parent, d\u00e9stabilise la prot\u00e9ine d\u00e8s le d\u00e9part. Elle peut toucher les nerfs, le c\u0153ur, ou les deux, et les sympt\u00f4mes peuvent appara\u00eetre \u00e0 tout \u00e2ge \u00e0 partir du d\u00e9but de l\u2019\u00e2ge adulte.<\/p>\n\t\t\t\t<p class=\"wp-block-paragraph\">Parce qu\u2019elle se transmet dans les familles, un diagnostic ne concerne jamais une seule personne.<\/p>\n\t\t\t\t\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\"><div class=\"wp-block-button aa-btn aa-btn--teal\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.amyloidosisalliance.org\/fr\/types-damylose\/amylose-attrv\/\">En savoir plus sur l\u2019ATTRv \u2192<\/a><\/div><\/div>\n\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\n\t\t\n\t\t<div class=\"wp-block-group aa-tp-note is-layout-flow wp-block-group-is-layout-flow\">\n\t\t\t<p class=\"wp-block-paragraph\">Dans le c\u0153ur, les deux formes peuvent \u00eatre identiques. Seul un test g\u00e9n\u00e9tique permet de les distinguer, c\u2019est pourquoi ce test fait partie du diagnostic, et pourquoi sa r\u00e9ponse concerne vos proches, et pas seulement vous.<\/p>\n\t\t<\/div>\n\t\t\n\t\t\n\t\t<div class=\"wp-block-group aa-tp-disclaimer is-layout-flow wp-block-group-is-layout-flow\">\n\t\t\t<p class=\"wp-block-paragraph\">Cette page est une information g\u00e9n\u00e9rale destin\u00e9e aux patients, aux familles et aux professionnels de sant\u00e9. Elle ne remplace pas un avis m\u00e9dical. Parlez toujours de votre situation avec votre \u00e9quipe sp\u00e9cialis\u00e9e.<\/p>\n\t\t<\/div>\n\t\t\n\t<\/div>\n\t\n<\/section>\n\n<section class=\"wp-block-group aa-next aa-next--split is-layout-flow wp-block-group-is-layout-flow\">\n\t\n\t<div class=\"wp-block-group aa-inner is-layout-flow wp-block-group-is-layout-flow\">\n\t\t\n\t\t<div class=\"wp-block-group aa-next__head is-layout-flow wp-block-group-is-layout-flow\">\n\t\t\t<p class=\"aa-section-num wp-block-paragraph\">Continuer<\/p>\n\t\t\t<h2 class=\"wp-block-heading\">Autres types<\/h2>\n\t\t<\/div>\n\t\t\n\t\t\n\t\t<div class=\"wp-block-group aa-next__grid is-layout-flow wp-block-group-is-layout-flow\">\n\t\t\t<div class=\"wp-block-group aa-next-card is-layout-flow wp-block-group-is-layout-flow\"><h3 class=\"wp-block-heading\"><a href=\"https:\/\/www.amyloidosisalliance.org\/fr\/types-damylose\/amylose-al\/\">Amylose AL<\/a><\/h3><p class=\"wp-block-paragraph\">La forme syst\u00e9mique la plus fr\u00e9quente, due aux cha\u00eenes l\u00e9g\u00e8res produites dans la moelle osseuse.<\/p><\/div>\n\t\t\t<div class=\"wp-block-group aa-next-card is-layout-flow wp-block-group-is-layout-flow\"><h3 class=\"wp-block-heading\"><a href=\"https:\/\/www.amyloidosisalliance.org\/fr\/types-damylose\/amylose-aa\/\">Amylose AA<\/a><\/h3><p class=\"wp-block-paragraph\">Une complication d\u2019une inflammation de longue dur\u00e9e, qui touche avant tout les reins.<\/p><\/div>\n\t\t\t<div class=\"wp-block-group aa-next-card is-layout-flow wp-block-group-is-layout-flow\"><h3 class=\"wp-block-heading\"><a href=\"https:\/\/www.amyloidosisalliance.org\/fr\/types-damylose\/autres-types\/\">Autres types<\/a><\/h3><p class=\"wp-block-paragraph\">Les formes h\u00e9r\u00e9ditaires rares, et l\u2019amylose localis\u00e9e, limit\u00e9e \u00e0 un seul site.<\/p><\/div>\n\t\t<\/div>\n\t\t\n\t<\/div>\n\t\n<\/section>\n","protected":false},"excerpt":{"rendered":"<p>Accueil\u203aAmylose\u203aTypes d\u2019amylose\u203aAmylose ATTR Types d\u2019amylose Amylose ATTR La transthyr\u00e9tine est une prot\u00e9ine fabriqu\u00e9e par le foie, dont le r\u00f4le est de transporter l\u2019hormone thyro\u00efdienne dans le sang. Tout le monde en poss\u00e8de. Dans l\u2019amylose ATTR, elle perd sa forme, s\u2019agr\u00e8ge en fibrilles et se d\u00e9pose dans les tissus, avant tout dans le c\u0153ur. Deux causes [&hellip;]<\/p>\n","protected":false},"author":0,"featured_media":0,"parent":1427,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-1409","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Amylose ATTR\u00a0: la forme \u00e0 transthyr\u00e9tine expliqu\u00e9e<\/title>\n<meta name=\"description\" content=\"La transthyr\u00e9tine peut perdre sa forme et se d\u00e9poser dans le c\u0153ur et les nerfs. 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