{"id":4259,"date":"2023-06-28T08:23:00","date_gmt":"2023-06-28T06:23:00","guid":{"rendered":"https:\/\/www.amyloidosisalliance.org\/los-avances-en-la-amiloidosis\/"},"modified":"2026-11-03T10:23:33","modified_gmt":"2026-11-03T09:23:33","slug":"los-avances-en-la-amiloidosis","status":"publish","type":"post","link":"https:\/\/www.amyloidosisalliance.org\/es\/los-avances-en-la-amiloidosis\/","title":{"rendered":"Los avances en la amiloidosis"},"content":{"rendered":"<\/p>\n\n\n<p class=\"wp-block-paragraph\">Durante casi 150 a\u00f1os despu\u00e9s de su descubrimiento, la amiloidosis se consider\u00f3 incurable. Hist\u00f3ricamente, la complejidad de la enfermedad fren\u00f3 la investigaci\u00f3n: \u00bfpor qu\u00e9 invertir tiempo y dinero en investigar una enfermedad tan compleja?<\/p>\n<p>\n<\/p><\/p>\n\n\n<p class=\"wp-block-paragraph\">En efecto, la amiloidosis es dif\u00edcil de diagnosticar por varias razones, sobre todo porque existen 36 subtipos conocidos. Once de ellos afectan directamente al coraz\u00f3n, mientras que otros afectan a otras partes del cuerpo.<\/p>\n<p>\n<\/p><\/p>\n\n\n<p class=\"wp-block-paragraph\">Afortunadamente para nuestros pacientes, el manejo de la amiloidosis ha evolucionado mucho a su favor en las \u00faltimas d\u00e9cadas, en tres frentes: el diagn\u00f3stico, el tratamiento y la investigaci\u00f3n.<\/p>\n<p>\n<\/p><\/p>\n\n\n<p class=\"wp-block-paragraph\">Este art\u00edculo se basa en el estudio: <a href=\"https:\/\/utswmed.org\/medblog\/cardiac-amyloidosis-doctor\/?fbclid=IwAR3jL4Ts9w6au4L9XCH9HFb0dWNg94G_2MQzQ76Ax23Tu22s9cC5nHcT2RQ\" target=\"_blank\" rel=\"noreferrer noopener\" style=\"font-family: var( --e-global-typography-text-font-family ), Sans-serif; font-weight: var( --e-global-typography-text-font-weight ); background-color: white; letter-spacing: 0.2px;\">Three parallel advances usher in new age of cardiac amyloidosis care<\/a>.<\/p>\n<p>\n<\/p><\/p>\n\n\n<h2 class=\"wp-block-heading\">El diagn\u00f3stico<\/h2>\n<p>\n<\/p><\/p>\n\n\n<p class=\"wp-block-paragraph\">Hasta ahora, el diagn\u00f3stico de la amiloidosis card\u00edaca ATTR (ATTR-CA) requer\u00eda una biopsia endomioc\u00e1rdica. Hoy, los avances de las tecnolog\u00edas de diagn\u00f3stico permiten confirmar una amiloidosis ATTR, una vez descartada la amiloidosis AL, por distintos medios, entre ellos las pruebas de imagen y los an\u00e1lisis de sangre y de orina.<\/p>\n<p>\n<\/p><\/p>\n\n\n<p class=\"wp-block-paragraph\">El primer paso del diagn\u00f3stico es la b\u00fasqueda de cadenas ligeras anormales. Para detectar estas anomal\u00edas, un an\u00e1lisis de sangre ya puede se\u00f1alar una urgencia diagn\u00f3stica. Tecnolog\u00edas como el electrocardiograma o la ecocardiograf\u00eda, combinadas, pueden aportar pruebas realmente s\u00f3lidas de una amiloidosis card\u00edaca. Solo cuando no se puede descartar la amiloidosis AL debe recurrirse a una biopsia endomioc\u00e1rdica para detectar la enfermedad. Cuando se descarta la amiloidosis AL, pueden realizarse otras pruebas como la gammagraf\u00eda, los an\u00e1lisis de sangre y de orina o la resonancia magn\u00e9tica card\u00edaca.<\/p>\n<p>\n<\/p><\/p>\n\n\n<h2 class=\"wp-block-heading\">Tratamiento<\/h2>\n<p>\n<\/p><\/p>\n\n\n<p class=\"wp-block-paragraph\">Para obtener los mejores resultados en el tratamiento de la amiloidosis, son esenciales un tratamiento precoz y una atenci\u00f3n coordinada. Algunos hospitales disponen de importantes equipamientos y de m\u00e9dicos especializados para intentar vencer esta enfermedad.<\/p>\n<p>\n<\/p><\/p>\n\n\n<p class=\"wp-block-paragraph\">Entre las combinaciones de tratamientos eficaces actuales figura la asociaci\u00f3n de quimioterapia y anticuerpos monoclonales, como el CyBorD y el daratumumab. La llegada de ciertos medicamentos tambi\u00e9n ha permitido estabilizar la enfermedad en algunos pacientes. Por ejemplo, la FDA autoriz\u00f3 el inoters\u00e9n y el patisir\u00e1n en 2018 para la amiloidosis ATTR hereditaria, y el tafamidis en 2019. Evidentemente, este tipo de tratamiento no cura la enfermedad, pero la ralentiza y reduce el riesgo de hospitalizaci\u00f3n o de muerte.<\/p>\n<p>\n<\/p><\/p>\n\n\n<h2 class=\"wp-block-heading\">Investigaci\u00f3n<\/h2>\n<p>\n<\/p><\/p>\n\n\n<p class=\"wp-block-paragraph\">Tras a\u00f1os casi sin investigaci\u00f3n sobre la amiloidosis, hoy podemos decir que est\u00e1 en pleno auge.<\/p>\n<p>\n<\/p><\/p>\n\n\n<p class=\"wp-block-paragraph\">Cada vez se realizan m\u00e1s ensayos cl\u00ednicos para conocer mejor la enfermedad con el fin de vencerla. Entre los m\u00e1s destacados:<\/p>\n<p>\n<\/p><\/p>\n\n<\/p>\n<ul class=\"wp-block-list\">\n<li style=\"list-style-type: none;\">\n<ul>\n\n\n\n\n<ul>\n<li style=\"list-style-type: none;\">\n<ul>\n<li>Estudio del anticuerpo monoclonal CAEL-101<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>\n<\/p>\n<\/p>\n<p>\n\n\n<ul>\n<li style=\"list-style-type: none;\">\n<ul>\n<li>Cardio TTRANSFORM<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>\n<\/p>\n<\/p>\n<p>\n\n\n<ul>\n<li style=\"list-style-type: none;\">\n<ul>\n<li>Seguridad, eficacia y farmacocin\u00e9tica del tafamidis<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>\n<\/p>\n<\/p>\n<p>\n<\/p>\n\n\n<p class=\"wp-block-paragraph\">Esta nueva era de la amiloidosis aporta esperanza a los pacientes. Esperamos que en el futuro el peregrinaje diagn\u00f3stico quede atr\u00e1s y que podamos conocer tratamientos cada vez m\u00e1s eficaces contra la amiloidosis.<\/p>\n<p>\n<\/p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Diagn\u00f3stico, tratamiento e investigaci\u00f3n: c\u00f3mo ha evolucionado la atenci\u00f3n de la amiloidosis card\u00edaca en las \u00faltimas d\u00e9cadas, a partir de una revisi\u00f3n de tres avances paralelos.<\/p>\n","protected":false},"author":1,"featured_media":4260,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[52],"tags":[],"class_list":["post-4259","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized-es"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Los avances en la amiloidosis<\/title>\n<meta name=\"description\" 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