{"id":2467,"date":"2026-07-10T15:18:47","date_gmt":"2026-07-10T13:18:47","guid":{"rendered":"https:\/\/www.amyloidosisalliance.org\/amiloidosis-attrwt\/"},"modified":"2026-10-22T15:23:18","modified_gmt":"2026-10-22T13:23:18","slug":"amiloidosis-attrwt","status":"publish","type":"page","link":"https:\/\/www.amyloidosisalliance.org\/es\/tipos-de-amiloidosis\/amiloidosis-attrwt\/","title":{"rendered":"Amiloidosis ATTRwt"},"content":{"rendered":"\n<nav aria-label=\"Breadcrumb\" class=\"wp-block-group aa-breadcrumb aa-events-hero__crumb is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"aa-inner\"><a href=\"\/\">Inicio<\/a><span class=\"aa-breadcrumb__sep\">\u203a<\/span><span class=\"aa-breadcrumb__label\">Amiloidosis<\/span><span class=\"aa-breadcrumb__sep\">\u203a<\/span><a href=\"https:\/\/www.amyloidosisalliance.org\/types-of-amyloidosis\/\">Tipos de amiloidosis<\/a><span class=\"aa-breadcrumb__sep\">\u203a<\/span><a href=\"https:\/\/www.amyloidosisalliance.org\/types-of-amyloidosis\/attr-amyloidosis\/\">Amiloidosis ATTR<\/a><span class=\"aa-breadcrumb__sep\">\u203a<\/span><span class=\"aa-breadcrumb__current\">ATTRwt<\/span><\/div>\n<\/nav>\n\n<section class=\"wp-block-group aa-events-hero aa-events-hero--art aa-events-hero--attrwt is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-inner is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"aa-events-hero__kicker wp-block-paragraph\">Amiloidosis ATTR<\/p>\n\n\n\n<h1 class=\"wp-block-heading\">Amiloidosis ATTRwt<\/h1>\n\n\n\n<p class=\"wp-block-paragraph\">En la amiloidosis ATTRwt no se identifica ninguna variante patog\u00e9nica de la TTR, pero la transtiretina puede volverse inestable con el envejecimiento. La enfermedad no es hereditaria. Se deposita sobre todo en el coraz\u00f3n y durante mucho tiempo se atribuy\u00f3 al envejecimiento normal; sin embargo, hoy puede identificarse mediante una prueba de imagen, a menudo sin biopsia.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-events-hero__art is-layout-flow wp-block-group-is-layout-flow\">\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" src=\"\/wp-content\/themes\/amyloidosis-alliance\/assets\/images\/disease\/attrwt.svg\" alt=\"Esquema: la transtiretina se disocia en subunidades que se pliegan mal, se alinean y se apilan hasta formar una fibrilla amiloide\"\/><\/figure>\n<\/div>\n<\/section>\n\n<nav aria-label=\"Section navigation\" class=\"wp-block-group aa-anchorband is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-inner is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-columns aa-anchor-cols is-layout-flex wp-container-core-columns-is-layout-b2e659ba wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column aa-anchor-item is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"num wp-block-paragraph\">01<\/p>\n\n\n\n<p class=\"lbl wp-block-paragraph\"><a href=\"#what\">\u00bfQu\u00e9 es la ATTRwt?<\/a><\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column aa-anchor-item is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"num wp-block-paragraph\">02<\/p>\n\n\n\n<p class=\"lbl wp-block-paragraph\"><a href=\"#causes\">C\u00f3mo se desarrolla<\/a><\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column aa-anchor-item is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"num wp-block-paragraph\">03<\/p>\n\n\n\n<p class=\"lbl wp-block-paragraph\"><a href=\"#symptoms\">S\u00edntomas<\/a><\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column aa-anchor-item is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"num wp-block-paragraph\">04<\/p>\n\n\n\n<p class=\"lbl wp-block-paragraph\"><a href=\"#diagnosis\">Diagn\u00f3stico<\/a><\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column aa-anchor-item is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"num wp-block-paragraph\">05<\/p>\n\n\n\n<p class=\"lbl wp-block-paragraph\"><a href=\"#treatment\">Tratamiento<\/a><\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column aa-anchor-item is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"num wp-block-paragraph\">06<\/p>\n\n\n\n<p class=\"lbl wp-block-paragraph\"><a href=\"#early\">Diagn\u00f3stico precoz<\/a><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/nav>\n\n<section id=\"what\" class=\"wp-block-group aa-section aa-section--white aa-what is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-inner is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"aa-section-num wp-block-paragraph\">01<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u00bfQu\u00e9 es la ATTRwt?<\/h2>\n\n\n\n<div class=\"wp-block-group aa-key-idea is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"aa-key-idea__label wp-block-paragraph\">Idea clave<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u00abWild-type\u00bb significa simplemente no mutada. Todos tenemos esta prote\u00edna. En algunas personas, la edad basta por s\u00ed sola para que se pliegue mal.<\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-what-cols is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-what-col is-layout-flow wp-block-group-is-layout-flow\">\n<h4 class=\"wp-block-heading\">Una prote\u00edna de transporte que se altera<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">La transtiretina (TTR) se produce en el h\u00edgado y transporta la hormona tiroidea por el organismo. Todos la tenemos, y en la ATTRwt el gen que la codifica es <strong>completamente normal<\/strong>: a eso se refiere el t\u00e9rmino \u00abwild-type\u00bb.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Por razones que siguen sin explicarse, la prote\u00edna cambia de forma con el paso de los a\u00f1os. Se vuelve insoluble, se agrega en fibrillas amiloides, y esas fibrillas se depositan en los tejidos.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-what-col is-layout-flow wp-block-group-is-layout-flow\">\n<h4 class=\"wp-block-heading\">Una enfermedad card\u00edaca de la edad avanzada<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Los dep\u00f3sitos se acumulan principalmente en el m\u00fasculo card\u00edaco. Durante mucho tiempo se habl\u00f3 de <em>amiloidosis senil<\/em>, como si no fuera m\u00e1s que el envejecimiento del coraz\u00f3n.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Tambi\u00e9n se cre\u00eda que solo afectaba a hombres blancos mayores de 75 a\u00f1os. Hoy se reconoce en mujeres y en personas de todos los or\u00edgenes \u00e9tnicos, y puede comenzar ya a los 50 a\u00f1os. Esa antigua creencia es una de las razones por las que el diagn\u00f3stico todav\u00eda se pasa por alto.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n\n<section id=\"causes\" class=\"wp-block-group aa-section aa-section--cream aa-forms is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-inner is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-centered-head is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"aa-section-num wp-block-paragraph\">02<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">C\u00f3mo se desarrolla la ATTRwt<\/h2>\n\n\n\n<div class=\"aa-divider-dot\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">Ni mutaci\u00f3n, ni inflamaci\u00f3n, ni un clon de c\u00e9lulas an\u00f3malas. Simplemente una prote\u00edna corriente que, con el tiempo, deja de mantener su forma.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-proc-grid is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-proc-step is-layout-flow wp-block-group-is-layout-flow\">\n<span class=\"aa-proc-step__icon\"><svg aria-hidden=\"true\" focusable=\"false\" width=\"24\" height=\"24\" viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><circle cx=\"12\" cy=\"12\" r=\"9\"><\/circle><circle cx=\"12\" cy=\"12\" r=\"3\"><\/circle><\/svg><\/span>\n\n\n\n<p class=\"aa-proc-step__num wp-block-paragraph\">Paso 01<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Una prote\u00edna normal<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">La transtiretina se produce en el h\u00edgado y transporta la hormona tiroidea. Su gen no est\u00e1 mutado: es la forma wild-type, la versi\u00f3n corriente que todos tenemos.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-proc-step is-layout-flow wp-block-group-is-layout-flow\">\n<span class=\"aa-proc-step__icon\"><svg aria-hidden=\"true\" focusable=\"false\" width=\"24\" height=\"24\" viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><circle cx=\"12\" cy=\"12\" r=\"9\"><\/circle><polyline points=\"12 7 12 12 15.5 14\"><\/polyline><\/svg><\/span>\n\n\n\n<p class=\"aa-proc-step__num wp-block-paragraph\">Paso 02<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">La edad la desestabiliza<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Con los a\u00f1os, y por razones a\u00fan mal comprendidas, la prote\u00edna cambia de conformaci\u00f3n. Pierde su solubilidad.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-proc-step is-layout-flow wp-block-group-is-layout-flow\">\n<span class=\"aa-proc-step__icon\"><svg aria-hidden=\"true\" focusable=\"false\" width=\"24\" height=\"24\" viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><polyline points=\"16 3 21 3 21 8\"><\/polyline><line x1=\"4\" y1=\"20\" x2=\"21\" y2=\"3\"><\/line><polyline points=\"21 16 21 21 16 21\"><\/polyline><line x1=\"15\" y1=\"15\" x2=\"21\" y2=\"21\"><\/line><line x1=\"4\" y1=\"4\" x2=\"9\" y2=\"9\"><\/line><\/svg><\/span>\n\n\n\n<p class=\"aa-proc-step__num wp-block-paragraph\">Paso 03<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Se forman fibrillas<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">La prote\u00edna desestabilizada se agrega en fibrillas amiloides insolubles, que el organismo no tiene forma de eliminar.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-proc-step is-layout-flow wp-block-group-is-layout-flow\">\n<span class=\"aa-proc-step__icon\"><svg aria-hidden=\"true\" focusable=\"false\" width=\"24\" height=\"24\" viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><path d=\"M19 14c1.49-1.46 3-3.21 3-5.5A5.5 5.5 0 0 0 16.5 3c-1.76 0-3 .5-4.5 2-1.5-1.5-2.74-2-4.5-2A5.5 5.5 0 0 0 2 8.5c0 2.29 1.51 4.04 3 5.5l7 7Z\"><\/path><\/svg><\/span>\n\n\n\n<p class=\"aa-proc-step__num wp-block-paragraph\">Paso 04<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">El coraz\u00f3n se vuelve r\u00edgido<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Los dep\u00f3sitos engrosan las paredes de los ventr\u00edculos. El coraz\u00f3n se llena mal; m\u00e1s tarde se contrae peor, y el gasto card\u00edaco disminuye.<\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-tp-alert aa-tp-alert--wide is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"wp-block-paragraph\">El s\u00edndrome del t\u00fanel carpiano, a menudo en ambas manos, puede aparecer de cinco a diez a\u00f1os antes de cualquier signo card\u00edaco. En una persona mayor, merece atenci\u00f3n.<\/p>\n<\/div>\n<\/div>\n<\/section>\n\n<section id=\"symptoms\" class=\"wp-block-group aa-section aa-section--white aa-tp-symptoms is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-inner is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-centered-head is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"aa-section-num wp-block-paragraph\">03<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">S\u00edntomas<\/h2>\n\n\n\n<div class=\"aa-divider-dot\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">El coraz\u00f3n domina el cuadro, pero rara vez es el primero en manifestarse. Las manos, los o\u00eddos y los pies suelen dar la alerta a\u00f1os antes.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-tp-organs aa-tp-organs--major is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-tp-organ is-layout-flow wp-block-group-is-layout-flow\">\n<h3 class=\"wp-block-heading\">El coraz\u00f3n<\/h3>\n\n\n\n<p class=\"aa-tp-organ__tag wp-block-paragraph\">Llenado y contracci\u00f3n<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Las paredes de los ventr\u00edculos se engrosan y el m\u00fasculo se vuelve r\u00edgido, de modo que el coraz\u00f3n se llena mal. M\u00e1s tarde su contracci\u00f3n tambi\u00e9n se debilita, y el gasto card\u00edaco disminuye. Esto provoca falta de aire (primero con el esfuerzo, despu\u00e9s en reposo, al hablar o al estar acostado), junto con cansancio, hinchaz\u00f3n de las piernas, aumento de peso y palpitaciones.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-tp-organ is-layout-flow wp-block-group-is-layout-flow\">\n<h3 class=\"wp-block-heading\">Ritmo card\u00edaco<\/h3>\n\n\n\n<p class=\"aa-tp-organ__tag wp-block-paragraph\">Una conducci\u00f3n alterada<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">La sustancia amiloide altera el sistema el\u00e9ctrico del coraz\u00f3n. El ritmo puede ser demasiado r\u00e1pido o demasiado lento y, en algunos casos, el coraz\u00f3n puede detenerse. A veces es necesario un marcapasos o un desfibrilador. Los desmayos, los mareos y las palpitaciones son los signos que hay que comunicar.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-tp-organ is-layout-flow wp-block-group-is-layout-flow\">\n<h3 class=\"wp-block-heading\">Nervios y audici\u00f3n<\/h3>\n\n\n\n<p class=\"aa-tp-organ__tag wp-block-paragraph\">A menudo pasados por alto<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">La audici\u00f3n puede disminuir. Los pies pueden sentirse como envueltos en algod\u00f3n, o notar hormigueo y pinchazos. Por separado, parecen las molestias corrientes de la edad, y esa es precisamente la dificultad.<\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-tp-organs aa-tp-organs--minor is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-tp-organ is-layout-flow wp-block-group-is-layout-flow\">\n<h3 class=\"wp-block-heading\">S\u00edndrome del t\u00fanel carpiano<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Con frecuencia es el primer signo, y con frecuencia en ambas manos a la vez. Puede preceder a los s\u00edntomas card\u00edacos en cinco a diez a\u00f1os.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-tp-organ is-layout-flow wp-block-group-is-layout-flow\">\n<h3 class=\"wp-block-heading\">La vida cotidiana<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Subir escaleras se vuelve costoso. Levantarse provoca mareos. Se pierde peso sin explicaci\u00f3n, y el tr\u00e1nsito intestinal alterna entre diarrea y estre\u00f1imiento.<\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-tp-flags is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-tp-flags__photo is-layout-flow wp-block-group-is-layout-flow\">\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"683\" height=\"1024\" src=\"https:\/\/www.amyloidosisalliance.org\/wp-content\/uploads\/2026\/09\/anatomical-model-of-a-human-heart-683x1024.jpg\" alt=\"Modelo anat&#xF3;mico de un coraz&#xF3;n humano\" class=\"wp-image-698\" srcset=\"https:\/\/www.amyloidosisalliance.org\/wp-content\/uploads\/2026\/09\/anatomical-model-of-a-human-heart-683x1024.jpg 683w, https:\/\/www.amyloidosisalliance.org\/wp-content\/uploads\/2026\/09\/anatomical-model-of-a-human-heart-200x300.jpg 200w, https:\/\/www.amyloidosisalliance.org\/wp-content\/uploads\/2026\/09\/anatomical-model-of-a-human-heart-768x1152.jpg 768w, https:\/\/www.amyloidosisalliance.org\/wp-content\/uploads\/2026\/09\/anatomical-model-of-a-human-heart-1024x1536.jpg 1024w, https:\/\/www.amyloidosisalliance.org\/wp-content\/uploads\/2026\/09\/anatomical-model-of-a-human-heart-1365x2048.jpg 1365w\" sizes=\"auto, (max-width: 683px) 100vw, 683px\" \/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-tp-flags__body is-layout-flow wp-block-group-is-layout-flow\">\n<h3 class=\"wp-block-heading\">Cu\u00e1ndo consultar<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Cada uno de estos signos es frecuente por s\u00ed solo con la edad. Varios a la vez, y sobre todo junto a un coraz\u00f3n engrosado que nadie ha sabido explicar, merecen ser investigados.<\/p>\n\n\n\n<ul class=\"wp-block-list aa-tp-flags__list\">\n<li>Tobillos hinchados, con una hinchaz\u00f3n que sube por las piernas<\/li>\n\n\n\n<li>Palpitaciones o latido card\u00edaco irregular<\/li>\n\n\n\n<li>Cansancio y debilidad<\/li>\n\n\n\n<li>Falta de aire ante el menor esfuerzo<\/li>\n\n\n\n<li>Dificultad para subir escaleras<\/li>\n\n\n\n<li>Entumecimiento u hormigueo en las manos y los pies<\/li>\n\n\n\n<li>Mareos al ponerse de pie<\/li>\n\n\n\n<li>Diarrea que alterna con estre\u00f1imiento<\/li>\n\n\n\n<li>P\u00e9rdida de peso involuntaria<\/li>\n<\/ul>\n\n\n\n<div class=\"wp-block-group aa-tp-alert is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"wp-block-paragraph\">Un coraz\u00f3n engrosado sin explicaci\u00f3n en una persona mayor, junto con un s\u00edndrome del t\u00fanel carpiano en ambas manos, debe llevar a buscar una amiloidosis ATTR.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n\n<section id=\"diagnosis\" class=\"wp-block-group aa-section aa-section--cream aa-tp-dx is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-inner is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-tp-dx__body is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"aa-section-num wp-block-paragraph\">04<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">C\u00f3mo se diagnostica la ATTRwt<\/h2>\n\n\n\n<p class=\"aa-tp-dx__intro wp-block-paragraph\">En esto la ATTRwt se diferencia de todas las dem\u00e1s formas de amiloidosis. En la mayor\u00eda de los casos, el diagn\u00f3stico puede establecerse hoy mediante una prueba de imagen, sin extraer un fragmento del coraz\u00f3n. Es uno de los verdaderos avances de las dos \u00faltimas d\u00e9cadas.<\/p>\n\n\n\n<div class=\"wp-block-group aa-tp-dx__steps is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-tp-dx__step is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"aa-tp-dx__step-num wp-block-paragraph\">01<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Examinar el coraz\u00f3n<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">La ecocardiograf\u00eda, o la resonancia magn\u00e9tica card\u00edaca, muestra el engrosamiento de las paredes de los ventr\u00edculos. Esto es lo que suele despertar la sospecha en primer lugar.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-tp-dx__step is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"aa-tp-dx__step-num wp-block-paragraph\">02<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">La gammagraf\u00eda \u00f3sea<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">El m\u00fasculo card\u00edaco capta un trazador \u00f3seo: una imagen llamativa y muy caracter\u00edstica. Cuando no se sospecha ning\u00fan otro tipo de amiloidosis, esto basta para establecer el diagn\u00f3stico, sin necesidad de biopsia.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-tp-dx__step is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"aa-tp-dx__step-num wp-block-paragraph\">03<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Descartar la amiloidosis AL<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Se buscan en la sangre y la orina las cadenas ligeras monoclonales de la amiloidosis AL, que se trata de una forma totalmente distinta. Si persiste la duda, se realiza una biopsia de las gl\u00e1ndulas salivales y, en ocasiones, del propio coraz\u00f3n.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-tp-dx__step is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"aa-tp-dx__step-num wp-block-paragraph\">04<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Una prueba gen\u00e9tica<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Es la <strong>\u00fanica<\/strong> manera de saber si la transtiretina est\u00e1 mutada (amiloidosis ATTR hereditaria) o es wild-type. La respuesta importa para usted y para su familia.<\/p>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-tp-dx__photo is-layout-flow wp-block-group-is-layout-flow\">\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"683\" src=\"https:\/\/www.amyloidosisalliance.org\/wp-content\/uploads\/2026\/09\/a-row-of-microscopes-in-a-laboratory-1024x683.jpg\" alt=\"Una fila de microscopios en un laboratorio\" class=\"wp-image-699\" srcset=\"https:\/\/www.amyloidosisalliance.org\/wp-content\/uploads\/2026\/09\/a-row-of-microscopes-in-a-laboratory-1024x683.jpg 1024w, https:\/\/www.amyloidosisalliance.org\/wp-content\/uploads\/2026\/09\/a-row-of-microscopes-in-a-laboratory-300x200.jpg 300w, https:\/\/www.amyloidosisalliance.org\/wp-content\/uploads\/2026\/09\/a-row-of-microscopes-in-a-laboratory-768x512.jpg 768w, https:\/\/www.amyloidosisalliance.org\/wp-content\/uploads\/2026\/09\/a-row-of-microscopes-in-a-laboratory-1536x1024.jpg 1536w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n<\/div>\n<\/div>\n<\/section>\n\n<section id=\"treatment\" class=\"wp-block-group aa-section aa-section--white aa-treating is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-inner is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-centered-head is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"aa-section-num wp-block-paragraph\">05<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Tratamiento<\/h2>\n\n\n\n<div class=\"aa-divider-dot\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">El tratamiento busca frenar o impedir la formaci\u00f3n de nueva sustancia amiloide y controlar los s\u00edntomas y las complicaciones card\u00edacas. Los tratamientos modificadores de la enfermedad act\u00faan sobre la propia transtiretina o sobre su producci\u00f3n, mientras que el tratamiento de soporte se adapta a cada paciente.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-tp-treat-lead is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-tp-treat-lead__photo is-layout-flow wp-block-group-is-layout-flow\">\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"683\" src=\"https:\/\/www.amyloidosisalliance.org\/wp-content\/uploads\/2026\/09\/a-pharmacist-selecting-medicines-from-a-shelf-1024x683.jpg\" alt=\"Una farmac&#xE9;utica eligiendo medicamentos de una estanter&#xED;a\" class=\"wp-image-700\" srcset=\"https:\/\/www.amyloidosisalliance.org\/wp-content\/uploads\/2026\/09\/a-pharmacist-selecting-medicines-from-a-shelf-1024x683.jpg 1024w, https:\/\/www.amyloidosisalliance.org\/wp-content\/uploads\/2026\/09\/a-pharmacist-selecting-medicines-from-a-shelf-300x200.jpg 300w, https:\/\/www.amyloidosisalliance.org\/wp-content\/uploads\/2026\/09\/a-pharmacist-selecting-medicines-from-a-shelf-768x512.jpg 768w, https:\/\/www.amyloidosisalliance.org\/wp-content\/uploads\/2026\/09\/a-pharmacist-selecting-medicines-from-a-shelf-1536x1024.jpg 1536w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-tp-treat-lead__body is-layout-flow wp-block-group-is-layout-flow\">\n<h3 class=\"wp-block-heading\">Estabilizar la prote\u00edna<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Los estabilizadores de la TTR son una opci\u00f3n de tratamiento modificador de la enfermedad para los pacientes que cumplen los criterios y tienen miocardiopat\u00eda ATTR. Se unen a la transtiretina y ayudan a estabilizar la prote\u00edna, lo que reduce su tendencia a plegarse mal y a formar nuevas fibrillas amiloides. Las indicaciones aprobadas y el acceso var\u00edan de un pa\u00eds a otro.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Otros enfoques modificadores de la enfermedad pueden reducir la producci\u00f3n de transtiretina o actuar sobre los dep\u00f3sitos amiloides. Su aprobaci\u00f3n, su disponibilidad y su lugar en el tratamiento var\u00edan de un pa\u00eds a otro y deben comentarse con un equipo especializado.<\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-treating-grid is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-treating-card is-layout-flow wp-block-group-is-layout-flow\">\n<span class=\"aa-icon-tile\"><svg aria-hidden=\"true\" focusable=\"false\" width=\"24\" height=\"24\" viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><path d=\"M12 22s8-4 8-10V5l-8-3-8 3v7c0 6 8 10 8 10z\"><\/path><\/svg><\/span>\n\n\n\n<h3 class=\"wp-block-heading\">Estabilizadores<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Los estabilizadores de la TTR se unen a la transtiretina y ayudan a mantener estable la prote\u00edna, lo que reduce su tendencia a plegarse mal y a formar fibrillas amiloides. La disponibilidad y las indicaciones aprobadas var\u00edan de un pa\u00eds a otro.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-treating-card is-layout-flow wp-block-group-is-layout-flow\">\n<span class=\"aa-icon-tile\"><svg aria-hidden=\"true\" focusable=\"false\" width=\"24\" height=\"24\" viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><path d=\"M2 15c6.667-6 13.333 0 20-6\"><\/path><path d=\"M2 9c6.667 6 13.333 0 20 6\"><\/path><line x1=\"7\" y1=\"6\" x2=\"9\" y2=\"8\"><\/line><line x1=\"15\" y1=\"16\" x2=\"17\" y2=\"18\"><\/line><\/svg><\/span>\n\n\n\n<h3 class=\"wp-block-heading\">Silenciadores g\u00e9nicos<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Las terapias de silenciamiento del gen TTR act\u00faan en un paso anterior, al reducir la cantidad de transtiretina que produce el h\u00edgado. Su uso en la miocardiopat\u00eda ATTRwt depende de la aprobaci\u00f3n regulatoria local y de la indicaci\u00f3n cl\u00ednica.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-treating-card is-layout-flow wp-block-group-is-layout-flow\">\n<span class=\"aa-icon-tile\"><svg aria-hidden=\"true\" focusable=\"false\" width=\"24\" height=\"24\" viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"1.75\" stroke-linecap=\"round\" stroke-linejoin=\"round\"><path d=\"M12 3l2.5 6.5L21 12l-6.5 2.5L12 21l-2.5-6.5L3 12l6.5-2.5z\"><\/path><\/svg><\/span>\n\n\n\n<h3 class=\"wp-block-heading\">En el horizonte<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Se est\u00e1n investigando terapias dise\u00f1adas para favorecer la eliminaci\u00f3n de la sustancia amiloide y otros enfoques modificadores de la enfermedad. Su papel futuro depender\u00e1 de los resultados de los ensayos cl\u00ednicos y de la aprobaci\u00f3n regulatoria.<\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-tp-support is-layout-flow wp-block-group-is-layout-flow\">\n<h4 class=\"wp-block-heading\">Cuidar el coraz\u00f3n, y qu\u00e9 evitar<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Reducir la sal, junto con los diur\u00e9ticos, alivia la falta de aire y la hinchaz\u00f3n. Cuando el ritmo es irregular, se utiliza un tratamiento anticoagulante para evitar que se formen co\u00e1gulos dentro del coraz\u00f3n.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Hay una trampa que conviene conocer. Varios medicamentos que se recetan de forma habitual en la insuficiencia card\u00edaca com\u00fan, entre ellos los betabloqueantes y los vasodilatadores, pueden empeorar la ATTRwt y a veces se retiran. Esa decisi\u00f3n corresponde a su cardi\u00f3logo. Nunca suspenda un tratamiento por su cuenta.<\/p>\n<\/div>\n<\/div>\n<\/section>\n\n<section id=\"early\" class=\"wp-block-group aa-section aa-section--forest aa-tp-outlook is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-inner is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-tp-outlook__photo is-layout-flow wp-block-group-is-layout-flow\">\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"683\" src=\"https:\/\/www.amyloidosisalliance.org\/wp-content\/uploads\/2026\/09\/an-intravenous-drip-stand-in-a-hospital-room-1024x683.jpg\" alt=\"Un soporte de goteo intravenoso en una habitaci&#xF3;n de hospital\" class=\"wp-image-701\" srcset=\"https:\/\/www.amyloidosisalliance.org\/wp-content\/uploads\/2026\/09\/an-intravenous-drip-stand-in-a-hospital-room-1024x683.jpg 1024w, https:\/\/www.amyloidosisalliance.org\/wp-content\/uploads\/2026\/09\/an-intravenous-drip-stand-in-a-hospital-room-300x200.jpg 300w, https:\/\/www.amyloidosisalliance.org\/wp-content\/uploads\/2026\/09\/an-intravenous-drip-stand-in-a-hospital-room-768x512.jpg 768w, https:\/\/www.amyloidosisalliance.org\/wp-content\/uploads\/2026\/09\/an-intravenous-drip-stand-in-a-hospital-room-1536x1024.jpg 1536w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-tp-outlook__body is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"aa-section-num wp-block-paragraph\">06<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Por qu\u00e9 importa el diagn\u00f3stico precoz<\/h2>\n\n\n\n<h4 class=\"wp-block-heading\">Detectada antes de que las paredes se engrosen<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">La afectaci\u00f3n de otras partes del organismo puede revelar la enfermedad card\u00edaca en una fase muy temprana, antes incluso de que aparezca cualquier engrosamiento de las paredes de los ventr\u00edculos. La prueba encuentra lo que el coraz\u00f3n a\u00fan no ha tenido tiempo de mostrar.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Los signos que aparecen primero<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">S\u00edndrome del t\u00fanel carpiano en ambas manos. Una audici\u00f3n que se apaga. Pies que hormiguean. Cada uno es f\u00e1cil de atribuir a la vejez; juntos, a\u00f1os antes de cualquier falta de aire, son lo primero que esta enfermedad revela de s\u00ed misma.<\/p>\n\n\n\n<p class=\"aa-tp-outlook__closing wp-block-paragraph\">Durante mucho tiempo se atribuy\u00f3 simplemente a la vejez. Hoy tiene un nombre, una prueba y un tratamiento.<\/p>\n<\/div>\n<\/div>\n<\/section>\n\n<section class=\"wp-block-group aa-section aa-section--white aa-tp-faq is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-inner is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-centered-head is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"aa-section-num wp-block-paragraph\">FAQ<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Preguntas frecuentes<\/h2>\n\n\n\n<div class=\"aa-divider-dot\"><\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-acc is-layout-flow wp-block-group-is-layout-flow\">\n<details class=\"wp-block-details is-layout-flow wp-block-details-is-layout-flow\"><summary>\u00bfLa ATTRwt es hereditaria?<\/summary>\n<p class=\"wp-block-paragraph\">No. En la ATTRwt, el gen de la transtiretina no presenta ninguna mutaci\u00f3n, y nada se transmite a sus hijos. Pero las dos formas no pueden distinguirse por sus s\u00edntomas, y precisamente por eso la prueba gen\u00e9tica forma parte del diagn\u00f3stico: distingue la forma wild-type de la amiloidosis ATTR hereditaria, en la que puede ser necesario ofrecer la prueba a los familiares.<\/p>\n<\/details>\n\n\n\n<details class=\"wp-block-details is-layout-flow wp-block-details-is-layout-flow\"><summary>\u00bfPor qu\u00e9 se llama \u00abwild-type\u00bb?<\/summary>\n<p class=\"wp-block-paragraph\">\u00abWild-type\u00bb es el t\u00e9rmino que usan los bi\u00f3logos para un gen o una prote\u00edna en su estado corriente, sin alterar, por oposici\u00f3n a una variante mutada. No dice nada de que la enfermedad sea agresiva. Significa simplemente: la prote\u00edna que todos tenemos.<\/p>\n<\/details>\n\n\n\n<details class=\"wp-block-details is-layout-flow wp-block-details-is-layout-flow\"><summary>\u00bfTener un s\u00edndrome del t\u00fanel carpiano significa que tengo ATTRwt?<\/summary>\n<p class=\"wp-block-paragraph\">Casi nunca. El s\u00edndrome del t\u00fanel carpiano es frecuente y por lo general no tiene nada que ver con la amiloidosis. Lo que merece investigarse es la combinaci\u00f3n: t\u00fanel carpiano en ambas manos, en una persona mayor, junto con un coraz\u00f3n engrosado que nadie ha sabido explicar.<\/p>\n<\/details>\n\n\n\n<details class=\"wp-block-details is-layout-flow wp-block-details-is-layout-flow\"><summary>\u00bfNecesitar\u00e9 una biopsia card\u00edaca?<\/summary>\n<p class=\"wp-block-paragraph\">Por lo general, no. La gammagraf\u00eda \u00f3sea permite establecer el diagn\u00f3stico sin biopsia, siempre que no se sospeche ning\u00fan otro tipo de amiloidosis. La biopsia se reserva para los casos en los que persiste la duda, y a menudo se toma de las gl\u00e1ndulas salivales y no del coraz\u00f3n.<\/p>\n<\/details>\n\n\n\n<details class=\"wp-block-details is-layout-flow wp-block-details-is-layout-flow\"><summary>\u00bfQu\u00e9 es la transtiretina?<\/summary>\n<p class=\"wp-block-paragraph\">Una prote\u00edna producida por el h\u00edgado, cuya funci\u00f3n es transportar la hormona tiroidea por la sangre. Todos la tenemos. En la amiloidosis ATTR pierde su forma y se agrega, ya sea porque el gen est\u00e1 mutado (amiloidosis ATTR hereditaria) o, como en este caso, simplemente con la edad.<\/p>\n<\/details>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-tp-disclaimer is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"wp-block-paragraph\">Esta p\u00e1gina ofrece informaci\u00f3n general dirigida a pacientes, familias y profesionales sanitarios. No sustituye el consejo m\u00e9dico. Las indicaciones aprobadas, el reembolso y la disponibilidad de los tratamientos de la amiloidosis ATTR var\u00edan de un pa\u00eds a otro. Los pacientes deben comentar con su equipo especializado las opciones disponibles localmente.<\/p>\n<\/div>\n<\/div>\n<\/section>\n\n<section class=\"wp-block-group aa-next aa-next--split is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-inner is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-next__head is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"aa-section-num wp-block-paragraph\">Continuar<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Otros tipos<\/h2>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-next__grid is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group aa-next-card is-layout-flow wp-block-group-is-layout-flow\">\n<h3 class=\"wp-block-heading\"><a href=\"https:\/\/www.amyloidosisalliance.org\/types-of-amyloidosis\/attrv-amyloidosis\/\">ATTRv<\/a><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">La forma hereditaria de la amiloidosis ATTR, causada por una mutaci\u00f3n en el gen de la transtiretina.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-next-card is-layout-flow wp-block-group-is-layout-flow\">\n<h3 class=\"wp-block-heading\"><a href=\"https:\/\/www.amyloidosisalliance.org\/types-of-amyloidosis\/al-amyloidosis\/\">Amiloidosis AL<\/a><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">La forma sist\u00e9mica m\u00e1s frecuente, causada por cadenas ligeras producidas en la m\u00e9dula \u00f3sea.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-group aa-next-card is-layout-flow wp-block-group-is-layout-flow\">\n<h3 class=\"wp-block-heading\"><a href=\"https:\/\/www.amyloidosisalliance.org\/types-of-amyloidosis\/aa-amyloidosis\/\">Amiloidosis AA<\/a><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Una complicaci\u00f3n de una inflamaci\u00f3n de larga duraci\u00f3n, que afecta sobre todo a los ri\u00f1ones.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n","protected":false},"excerpt":{"rendered":"<p>Inicio\u203aAmiloidosis\u203aTipos de amiloidosis\u203aAmiloidosis ATTR\u203aATTRwt Amiloidosis ATTR Amiloidosis ATTRwt En la amiloidosis ATTRwt no se identifica ninguna variante patog\u00e9nica de la TTR, pero la transtiretina puede volverse inestable con el envejecimiento. La enfermedad no es hereditaria. Se deposita sobre todo en el coraz\u00f3n y durante mucho tiempo se atribuy\u00f3 al envejecimiento normal; sin embargo, hoy puede [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":2475,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-2467","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Amiloidosis ATTRwt: la forma wild-type de la amiloidosis ATTR<\/title>\n<meta name=\"description\" content=\"En la amiloidosis ATTRwt no se encuentra ninguna variante de la TTR: la prote\u00edna se desestabiliza con la edad. 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